6O0P
| crystal structure of BCL-2 G101A mutation with venetoclax | Descriptor: | 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, DI(HYDROXYETHYL)ETHER | Authors: | Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E. | Deposit date: | 2019-02-17 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nat Commun, 10, 2019
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6O0M
| crystal structure of BCL-2 F104L mutation with venetoclax | Descriptor: | 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, DI(HYDROXYETHYL)ETHER | Authors: | Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E. | Deposit date: | 2019-02-16 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nat Commun, 10, 2019
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6O0K
| crystal structure of BCL-2 with venetoclax | Descriptor: | 4-{4-[(4'-chloro-5,5-dimethyl[3,4,5,6-tetrahydro[1,1'-biphenyl]]-2-yl)methyl]piperazin-1-yl}-N-[(3-nitro-4-{[(oxan-4-yl )methyl]amino}phenyl)sulfonyl]-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]benzamide, Apoptosis regulator Bcl-2, NONAETHYLENE GLYCOL | Authors: | Birkinshaw, R.W, Luo, C.S, Colman, P.M, Czabotar, P.E. | Deposit date: | 2019-02-16 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations. Nat Commun, 10, 2019
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2X8L
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7K02
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7LV3
| Crystal structure of human protein kinase G (PKG) R-C complex in inhibited state | Descriptor: | 1,2-ETHANEDIOL, Isoform Beta of cGMP-dependent protein kinase 1, MANGANESE (II) ION, ... | Authors: | Sharma, R, Lying, Q, Casteel, D, Kim, C. | Deposit date: | 2021-02-23 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | An auto-inhibited state of protein kinase G and implications for selective activation. Elife, 11, 2022
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1QF3
| PEANUT LECTIN COMPLEXED WITH METHYL-BETA-GALACTOSE | Descriptor: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN), ... | Authors: | Ravishankar, R, Suguna, K, Surolia, A, Vijayan, M. | Deposit date: | 1999-04-06 | Release date: | 1999-07-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of the complexes of peanut lectin with methyl-beta-galactose and N-acetyllactosamine and a comparative study of carbohydrate binding in Gal/GalNAc-specific legume lectins. Acta Crystallogr.,Sect.D, 55, 1999
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1BZW
| PEANUT LECTIN COMPLEXED WITH C-LACTOSE | Descriptor: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN), ... | Authors: | Ravishankar, R, Surolia, A, Vijayan, M, Lim, S, Kishi, Y. | Deposit date: | 1998-11-05 | Release date: | 1998-11-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Preferred Conformation of C-Lactose at the Free and Peanut Lectin Bound States J.Am.Chem.Soc., 120, 1998
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1YYE
| Crystal structure of estrogen receptor beta complexed with way-202196 | Descriptor: | 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE, Estrogen receptor beta, STEROID RECEPTOR COACTIVATOR-1 | Authors: | Mewshaw, R.E, Edsall Jr, R.J, Yang, C, Manas, E.S, Xu, Z.B, Henderson, R.A, Keith Jr, J.C, Harris, H.A. | Deposit date: | 2005-02-24 | Release date: | 2006-02-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity J.Med.Chem., 48, 2005
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1CR7
| PEANUT LECTIN-LACTOSE COMPLEX MONOCLINIC FORM | Descriptor: | CALCIUM ION, LECTIN, MANGANESE (II) ION, ... | Authors: | Ravishankar, R, Suguna, K, Surolia, A, Vijayan, M. | Deposit date: | 1999-08-14 | Release date: | 2001-04-21 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of the peanut lectin-lactose complex at acidic pH: retention of unusual quaternary structure, empty and carbohydrate bound combining sites, molecular mimicry and crystal packing directed by interactions at the combining site. Proteins, 43, 2001
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8QHC
| Cryo-EM structure of SidH from Legionella pneumophila in complex with LubX | Descriptor: | E3 ubiquitin--protein ligase, Elongation factor Tu, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Sharma, R, Adams, M, Bhogaraju, S. | Deposit date: | 2023-09-07 | Release date: | 2023-10-11 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for the toxicity of Legionella pneumophila effector SidH. Nat Commun, 14, 2023
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8QFS
| Cryo-EM structure of SidH from Legionella pneumophila | Descriptor: | Elongation factor Tu, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Sharma, R, Weis, F, Bhogaraju, S. | Deposit date: | 2023-09-04 | Release date: | 2023-10-11 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for the toxicity of Legionella pneumophila effector SidH. Nat Commun, 14, 2023
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1YY4
| Crystal structure of estrogen receptor beta complexed with 1-chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol | Descriptor: | 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL, Estrogen receptor beta, STEROID RECEPTOR COACTIVATOR-1 | Authors: | Mewshaw, R.E, Edsall Jr, R.J, Yang, C, Manas, E.S, Xu, Z.B, Henderson, R.A, Keith Jr, J.C, Harris, H.A. | Deposit date: | 2005-02-23 | Release date: | 2006-02-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity J.Med.Chem., 48, 2005
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1CIW
| PEANUT LECTIN COMPLEXED WITH N-ACETYLLACTOSAMINE | Descriptor: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN), ... | Authors: | Ravishankar, R, Suguna, K, Surolia, A, Vijayan, M. | Deposit date: | 1999-04-06 | Release date: | 1999-07-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structures of the complexes of peanut lectin with methyl-beta-galactose and N-acetyllactosamine and a comparative study of carbohydrate binding in Gal/GalNAc-specific legume lectins. Acta Crystallogr.,Sect.D, 55, 1999
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1EUI
| ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE COMPLEX WITH URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN | Descriptor: | URACIL-DNA GLYCOSYLASE, URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN | Authors: | Ravishankar, R, Sagar, M.B, Roy, S, Purnapatre, K, Handa, P, Varshney, U, Vijayan, M. | Deposit date: | 1998-06-18 | Release date: | 1999-06-22 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | X-ray analysis of a complex of Escherichia coli uracil DNA glycosylase (EcUDG) with a proteinaceous inhibitor. The structure elucidation of a prokaryotic UDG. Nucleic Acids Res., 26, 1998
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1CKR
| HIGH RESOLUTION SOLUTION STRUCTURE OF THE HEAT SHOCK COGNATE-70 KD SUBSTRATE BINDING DOMAIN OBTAINED BY MULTIDIMENSIONAL NMR TECHNIQUES | Descriptor: | HEAT SHOCK SUBSTRATE BINDING DOMAIN OF HSC-70 | Authors: | Morshauser, R.C, Hu, W, Wang, H, Pang, Y, Flynn, G.C, Zuiderweg, E.R.P. | Deposit date: | 1999-04-22 | Release date: | 1999-04-30 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70. J.Mol.Biol., 289, 1999
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1CQ9
| PEANUT LECTIN-TRICLINIC FORM | Descriptor: | CALCIUM ION, MANGANESE (II) ION, PROTEIN (PEANUT LECTIN) | Authors: | Ravishankar, R, Suguna, K, Surolia, A, Vijayan, M. | Deposit date: | 1999-08-06 | Release date: | 2002-05-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structures of the peanut lectin-lactose complex at acidic pH: retention of unusual
quaternary structure, empty and carbohydrate bound combining sites, molecular mimicry
and crystal packing directed by interactions at the combining site. Proteins, 43, 2001
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6UX8
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7L99
| Crystal structure of BRDT bromodomain 2 in complex with CDD-1302 | Descriptor: | Bromodomain testis-specific protein, N-[3-(acetylamino)-4-methylphenyl]-3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carboxamide, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) | Authors: | Sharma, R, Yu, Z, Ku, A.F, Anglin, J.L, Ucisik, M.N, Faver, J.C, Sankaran, B, Kim, C, Matzuk, M.M. | Deposit date: | 2021-01-03 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc.Natl.Acad.Sci.USA, 118, 2021
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7L9A
| Crystal structure of BRDT bromodomain 2 in complex with CDD-1102 | Descriptor: | BETA-MERCAPTOETHANOL, Bromodomain testis-specific protein, N~1~-(5-{[3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carbonyl]amino}-2-methylphenyl)-N~4~-methylbenzene-1,4-dicarboxamide | Authors: | Sharma, R, Kaur, G, Yu, Z, Ku, A.F, Anglin, J.L, Ucisik, M.N, Faver, J.C, Sankaran, B, Kim, C, Matzuk, M.M. | Deposit date: | 2021-01-03 | Release date: | 2021-06-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc.Natl.Acad.Sci.USA, 118, 2021
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4X6C
| CD1a ternary complex with lysophosphatidylcholine and BK6 TCR | Descriptor: | (4R,7R,18Z)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | Authors: | Birkinshaw, R.W, Rossjohn, J. | Deposit date: | 2014-12-08 | Release date: | 2015-01-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands. Nat.Immunol., 16, 2015
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4X6D
| CD1a ternary complex with endogenous lipids and BK6 TCR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, OLEIC ACID, ... | Authors: | Birkinshaw, R.W, Rossjohn, J. | Deposit date: | 2014-12-08 | Release date: | 2015-01-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands. Nat.Immunol., 16, 2015
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4X6F
| CD1a binary complex with sphingomyelin | Descriptor: | (4S,7S,23Z)-4-hydroxy-7-[(1S,2Z)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-9-oxo-3,5-dioxa-8-aza-4-phosphadotriacont- 23-en-1-aminium 4-oxide, Beta-2-microglobulin, T-cell surface glycoprotein CD1a | Authors: | Birkinshaw, R.W, Rossjohn, J. | Deposit date: | 2014-12-08 | Release date: | 2015-02-04 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands. Nat.Immunol., 16, 2015
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5H23
| Crystal structure of Chikungunya virus capsid protein | Descriptor: | 1,2-ETHANEDIOL, Capsid Protein, DI(HYDROXYETHYL)ETHER, ... | Authors: | Sharma, R, Kesari, P, Tomar, S, Kumar, P. | Deposit date: | 2016-10-14 | Release date: | 2018-03-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-function insights into chikungunya virus capsid protein: Small molecules targeting capsid hydrophobic pocket. Virology, 515, 2018
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4X6E
| CD1a binary complex with lysophosphatidylcholine | Descriptor: | (4R,7R,18Z)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Beta-2-microglobulin, D-MALATE, ... | Authors: | Birkinshaw, R.W, Rossjohn, J. | Deposit date: | 2014-12-08 | Release date: | 2015-01-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands. Nat.Immunol., 16, 2015
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