7EM7
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![BU of 7em7 by Molmil](/molmil-images/mine/7em7) | Crystal structure of the PI5P4Kbeta N203D-XTP complex | Descriptor: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | Authors: | Senda, M, Senda, T. | Deposit date: | 2021-04-13 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30, 2022
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7EM3
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![BU of 7em3 by Molmil](/molmil-images/mine/7em3) | Crystal structure of the PI5P4Kbeta-2a-ATP complex | Descriptor: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | Authors: | Senda, M, Senda, T. | Deposit date: | 2021-04-13 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30, 2022
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7EM4
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![BU of 7em4 by Molmil](/molmil-images/mine/7em4) | Crystal structure of the PI5P4Kbeta F205L-ITP complex | Descriptor: | INOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | Authors: | Senda, M, Senda, T. | Deposit date: | 2021-04-13 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30, 2022
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7EM8
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![BU of 7em8 by Molmil](/molmil-images/mine/7em8) | Crystal structure of the PI5P4Kbeta T201M-2a-ATP complex | Descriptor: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | Authors: | Senda, M, Senda, T. | Deposit date: | 2021-04-13 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30, 2022
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7EM5
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![BU of 7em5 by Molmil](/molmil-images/mine/7em5) | Crystal structure of the PI5P4Kbeta F205L-XTP complex | Descriptor: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | Authors: | Senda, M, Senda, T. | Deposit date: | 2021-04-13 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30, 2022
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7EM2
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![BU of 7em2 by Molmil](/molmil-images/mine/7em2) | Crystal structure of the PI5P4Kbeta-XTP complex | Descriptor: | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | Authors: | Senda, M, Senda, T. | Deposit date: | 2021-04-13 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30, 2022
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7EM1
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![BU of 7em1 by Molmil](/molmil-images/mine/7em1) | Crystal structure of the PI5P4Kbeta-ITP complex | Descriptor: | INOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | Authors: | Senda, M, Senda, T. | Deposit date: | 2021-04-13 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30, 2022
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7E18
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![BU of 7e18 by Molmil](/molmil-images/mine/7e18) | Crystal structure of SAR-CoV-2 3CL protease complex with inhibitor YH-53 | Descriptor: | 1,2-ETHANEDIOL, N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, Replicase polyprotein 1ab | Authors: | Senda, M, Konno, S, Hayashi, Y, Senda, T. | Deposit date: | 2021-02-01 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. J.Med.Chem., 65, 2022
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7E19
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![BU of 7e19 by Molmil](/molmil-images/mine/7e19) | Crystal structure of SAR-CoV-2 3CL protease complex with inhibitor SH-5 | Descriptor: | (phenylmethyl) N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]carbamate, 3C-like proteinase | Authors: | Senda, M, Konno, S, Hayashi, Y, Senda, T. | Deposit date: | 2021-02-01 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. J.Med.Chem., 65, 2022
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2IO5
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![BU of 2io5 by Molmil](/molmil-images/mine/2io5) | Crystal structure of the CIA- histone H3-H4 complex | Descriptor: | ASF1A protein, Histone H3.1, Histone H4 | Authors: | Natsume, R, Akai, Y, Horikoshi, M, Senda, T. | Deposit date: | 2006-10-10 | Release date: | 2007-02-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure and function of the histone chaperone CIA/ASF1 complexed with histones H3 and H4. Nature, 446, 2007
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5YJE
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![BU of 5yje by Molmil](/molmil-images/mine/5yje) | Crystal structure of HIRA(644-1017) | Descriptor: | Protein HIRA, SULFATE ION | Authors: | Sato, Y, Senda, M, Senda, T. | Deposit date: | 2017-10-10 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit Nat Commun, 9, 2018
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2Z8U
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![BU of 2z8u by Molmil](/molmil-images/mine/2z8u) | Methanococcus jannaschii TBP | Descriptor: | TATA-box-binding protein | Authors: | Adachi, N, Senda, T, Horikoshi, M. | Deposit date: | 2007-09-10 | Release date: | 2008-08-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of Methanococcus jannaschii TATA box-binding protein. Genes Cells, 13, 2008
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5ZM4
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![BU of 5zm4 by Molmil](/molmil-images/mine/5zm4) | Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AndA with preandiloid C | Descriptor: | (6aS,8aR,12aS,12bR,13aR)-5,6a,9,9,12a,13a-hexamethyl-7,8,8a,9,12a,12b,13,13a-octahydro-3H-benzo[a]furo[3,4-j]xanthene-3,4,10(1H,6aH)-trione, 2-OXOGLUTARIC ACID, Dioxygenase andA, ... | Authors: | Nakashima, Y, Senda, T. | Deposit date: | 2018-04-01 | Release date: | 2018-07-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis. J. Am. Chem. Soc., 140, 2018
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7D98
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![BU of 7d98 by Molmil](/molmil-images/mine/7d98) | |
7D6Q
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![BU of 7d6q by Molmil](/molmil-images/mine/7d6q) | Crystal structure of the Stx2a | Descriptor: | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Shiga toxin 2 B subunit, rRNA N-glycosylase | Authors: | Takahashi, M, Tamada, M, Hibino, M, Senda, M, Okuda, A, Miyazawa, A, Senda, T, Nishikawa, K. | Deposit date: | 2020-10-01 | Release date: | 2021-04-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin. Commun Biol, 4, 2021
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7D6R
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![BU of 7d6r by Molmil](/molmil-images/mine/7d6r) | Crystal structure of the Stx2a complexed with MMA betaAla peptide | Descriptor: | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, MMA betaAla peptide, Shiga toxin 2 B subunit, ... | Authors: | Takahashi, M, Tamada, M, Hibino, M, Senda, M, Okuda, A, Miyazawa, A, Senda, T, Nishikawa, K. | Deposit date: | 2020-10-01 | Release date: | 2021-04-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin. Commun Biol, 4, 2021
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5ZM2
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![BU of 5zm2 by Molmil](/molmil-images/mine/5zm2) | |
7DRE
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![BU of 7dre by Molmil](/molmil-images/mine/7dre) | Cryo-EM structure of DfgA-B at 2.54 angstrom resolution | Descriptor: | DfgB, Sugar phosphate isomerase/epimerase | Authors: | Mori, T, Moriya, T, Adachi, N, Senda, T, Abe, I. | Deposit date: | 2020-12-28 | Release date: | 2021-12-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes. Nat Commun, 12, 2021
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7DRD
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![BU of 7drd by Molmil](/molmil-images/mine/7drd) | Cryo-EM structure of DgpB-C at 2.85 angstrom resolution | Descriptor: | AP_endonuc_2 domain-containing protein, DgpB | Authors: | Mori, T, Moriya, T, Adachi, N, Senda, T, Abe, I. | Deposit date: | 2020-12-28 | Release date: | 2021-12-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes. Nat Commun, 12, 2021
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3A2M
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![BU of 3a2m by Molmil](/molmil-images/mine/3a2m) | CRYSTAL STRUCTURE OF DBJA (WILD TYPE Type I) | Descriptor: | CHLORIDE ION, Haloalkane dehalogenase, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | Authors: | Sato, Y, Senda, T. | Deposit date: | 2009-05-23 | Release date: | 2010-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering Angew.Chem.Int.Ed.Engl., 49, 2010
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3A2L
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![BU of 3a2l by Molmil](/molmil-images/mine/3a2l) | Crystal structure of DBJA (mutant dbja delta) | Descriptor: | CHLORIDE ION, GLYCEROL, Haloalkane dehalogenase, ... | Authors: | Sato, Y, Senda, T. | Deposit date: | 2009-05-23 | Release date: | 2010-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering Angew.Chem.Int.Ed.Engl., 49, 2010
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3AFI
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![BU of 3afi by Molmil](/molmil-images/mine/3afi) | Crystal structure of DBJA (HIS-DBJA) | Descriptor: | CHLORIDE ION, Haloalkane dehalogenase | Authors: | Sato, Y, Senda, T. | Deposit date: | 2010-03-02 | Release date: | 2011-01-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering Angew.Chem.Int.Ed.Engl., 49, 2010
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3A2N
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![BU of 3a2n by Molmil](/molmil-images/mine/3a2n) | Crystal structure of DBJA (Wild Type Type II P21) | Descriptor: | CHLORIDE ION, Haloalkane dehalogenase | Authors: | Sato, Y, Senda, T. | Deposit date: | 2009-05-23 | Release date: | 2010-05-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Enantioselectivity of haloalkane dehalogenases and its modulation by surface loop engineering Angew.Chem.Int.Ed.Engl., 49, 2010
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1KW6
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![BU of 1kw6 by Molmil](/molmil-images/mine/1kw6) | Crystal structure of 2,3-dihydroxybiphenyl dioxygenase (BphC) in complex with 2,3-dihydroxybiphenyl at 1.45 A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2,3-Dihydroxybiphenyl dioxygenase, BIPHENYL-2,3-DIOL, ... | Authors: | Sato, N, Uragami, Y, Nishizaki, T, Takahashi, Y, Sazaki, G, Sugimoto, K, Nonaka, T, Masai, E, Fukuda, M, Senda, T. | Deposit date: | 2002-01-28 | Release date: | 2003-01-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal Structures of the Reaction Intermediate and its Homologue of an Extradiol-cleaving Catecholic Dioxygenase J.Mol.Biol., 321, 2002
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1KW3
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![BU of 1kw3 by Molmil](/molmil-images/mine/1kw3) | Crystal structure of 2,3-dihydroxybiphenyal dioxygenase (BphC) at 1.45 A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2,3-Dihydroxybiphenyl dioxygenase, FE (II) ION | Authors: | Sato, N, Uragami, Y, Nishizaki, T, Takahashi, Y, Sazaki, G, Sugimoto, K, Nonaka, T, Masai, E, Fukuda, M, Senda, T. | Deposit date: | 2002-01-28 | Release date: | 2003-01-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Crystal Structures of the Reaction Intermediate and its Homologue of an Extradiol-cleaving Catecholic Dioxygenase J.Mol.Biol., 321, 2002
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