7EM1
Crystal structure of the PI5P4Kbeta-ITP complex
Summary for 7EM1
Entry DOI | 10.2210/pdb7em1/pdb |
Descriptor | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, INOSINE-5'-DIPHOSPHATE, [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(6-oxidanylidene-1~{H}-purin-9-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (3 entities in total) |
Functional Keywords | lipid kinase, phosphoinositide signaling, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 91222.34 |
Authors | |
Primary citation | Takeuchi, K.,Ikeda, Y.,Senda, M.,Harada, A.,Okuwaki, K.,Fukuzawa, K.,Nakagawa, S.,Yu, H.Y.,Nagase, L.,Imai, M.,Sasaki, M.,Lo, Y.H.,Ito, D.,Osaka, N.,Fujii, Y.,Sasaki, A.T.,Senda, T. The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30:886-899.e4, 2022 Cited by PubMed: 35504278DOI: 10.1016/j.str.2022.04.004 PDB entries with the same primary citation |
Experimental method |
Structure validation
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