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PDB: 57 results

6EKU
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Vibrio cholerae neuraminidase complexed with zanamivir
Descriptor: CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Schuetz, A, Heinemann, U.
Deposit date:2017-09-27
Release date:2017-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases as Assessed in a Cell-Free Fluorescence-Based Enzyme Inhibition Assay.
Molecules, 22, 2017
6EKS
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BU of 6eks by Molmil
Vibrio cholerae neuraminidase complexed with oseltamivir carboxylate
Descriptor: (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, GLYCEROL, ...
Authors:Schuetz, A, Heinemann, U.
Deposit date:2017-09-27
Release date:2017-11-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Different Inhibitory Potencies of Oseltamivir Carboxylate, Zanamivir, and Several Tannins on Bacterial and Viral Neuraminidases as Assessed in a Cell-Free Fluorescence-Based Enzyme Inhibition Assay.
Molecules, 22, 2017
4ULW
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BU of 4ulw by Molmil
Crystal structure of the ROQ-domain of human ROQUIN1
Descriptor: ROQUIN-1
Authors:Schuetz, A, Heinemann, U.
Deposit date:2014-05-14
Release date:2015-01-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Roquin Binding to Target Mrnas Involves a Winged Helix-Turn- Helix Motif.
Nat.Commun., 5, 2014
8OMI
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BU of 8omi by Molmil
Crystal structure of the inositol hexakisphosphate kinase EhIP6KA M85 variant in complex with ATP and Mg2+
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Schuetz, A, Aguirre, T, Fiedler, D.
Deposit date:2023-03-31
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor.
Elife, 12, 2023
3TT9
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BU of 3tt9 by Molmil
Crystal structure of the stable degradation fragment of human plakophilin 2 isoform a (PKP2a) C752R variant
Descriptor: GLYCEROL, Plakophilin-2
Authors:Schuetz, A, Roske, Y, Gerull, B, Heinemann, U.
Deposit date:2011-09-14
Release date:2012-08-01
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.
Circ Cardiovasc Genet, 5, 2012
2WBU
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BU of 2wbu by Molmil
CRYSTAL STRUCTURE OF THE ZINC FINGER DOMAIN OF KLF4 BOUND TO ITS TARGET DNA
Descriptor: 5'-D(*DGP*DAP*DGP*DGP*DCP*DGP*DTP* DGP*DGP*DC)-3', 5'-D(*DGP*DCP*DCP*DAP*DCP*DGP*DCP* DCP*DTP*DC)-3', KRUEPPEL-LIKE FACTOR 4, ...
Authors:Schuetz, A, Zocher, G, Carstanjen, D, Heinemann, U.
Deposit date:2009-03-05
Release date:2010-04-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Structure of the Klf4 DNA-Binding Domain Links to Self-Renewal and Macrophage Differentiation.
Cell.Mol.Life Sci., 68, 2011
5N7I
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BU of 5n7i by Molmil
Crystal structure of the coiled-coil domain of human tricellulin
Descriptor: MARVEL domain-containing protein 2
Authors:Schuetz, A, Heinemann, U.
Deposit date:2017-02-20
Release date:2017-07-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
Ann. N. Y. Acad. Sci., 1405, 2017
5MR7
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BU of 5mr7 by Molmil
Crystal structure of the DBD domain of human Grhl2
Descriptor: Grainyhead-like protein 2 homolog
Authors:Schuetz, A, Ming, Q, Roske, Y, Heinemann, U.
Deposit date:2016-12-21
Release date:2018-01-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Nucleic Acids Res., 46, 2018
5N7H
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BU of 5n7h by Molmil
Crystal structure of the coiled-coil domain of human tricellulin
Descriptor: MARVEL domain-containing protein 2
Authors:Schuetz, A, Heinemann, U.
Deposit date:2017-02-20
Release date:2017-07-12
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
Ann. N. Y. Acad. Sci., 1405, 2017
5N7K
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BU of 5n7k by Molmil
Crystal structure of the coiled-coil domain of human tricellulin
Descriptor: MARVEL domain-containing protein 2
Authors:Schuetz, A, Heinemann, U.
Deposit date:2017-02-20
Release date:2017-07-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Crystal structure of the tricellulin C-terminal coiled-coil domain reveals a unique mode of dimerization.
Ann. N. Y. Acad. Sci., 1405, 2017
7ZIH
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BU of 7zih by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor AG-01-128
Descriptor: 8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dione, DI(HYDROXYETHYL)ETHER, FE (III) ION, ...
Authors:Schuetz, A, Gogolin, A, Pfeifer, J, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2022-04-08
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.46890831 Å)
Cite:Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZII
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BU of 7zii by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-193
Descriptor: 8-(5~{H}-[1,3]dioxolo[4,5-f]benzimidazol-6-ylmethyl)-7-(phenylmethyl)-3-propyl-purine-2,6-dione, FE (III) ION, GLYCEROL, ...
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2022-04-08
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6280005 Å)
Cite:Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZIJ
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BU of 7zij by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-080
Descriptor: 8-(1~{H}-benzimidazol-2-ylmethyl)-3-cyclopropyl-7-(phenylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2022-04-08
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.94678366 Å)
Cite:Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZIG
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BU of 7zig by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-060
Descriptor: (2~{R})-2-azanyl-5-[[2-[[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]methyl]-1~{H}-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2022-04-08
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.808885 Å)
Cite:Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZIF
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BU of 7zif by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-480
Descriptor: (2R)-2-azanyl-5-[[2-[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]sulfanyl-3H-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, GLYCEROL, ...
Authors:Schuetz, A, Ziebart, N, Weise, M, Mallow, K, Pfeifer, J, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2022-04-08
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.86859715 Å)
Cite:Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
7ZIK
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BU of 7zik by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP533401
Descriptor: (2~{R})-2-azanyl-3-[4-[2-azanyl-6-[(1~{R})-1-[4-chloranyl-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]phenyl]propanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Schuetz, A, Heinemann, U.
Deposit date:2022-04-08
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.58925915 Å)
Cite:Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 65, 2022
8CJL
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BU of 8cjl by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor TPT-004
Descriptor: 3-ethyl-8-[(2-methyl-5~{H}-imidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-(oxetan-3-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2023-02-13
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJO
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BU of 8cjo by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-004
Descriptor: 1-[(3~{S})-3-(4-chloranyl-2-fluoranyl-phenyl)-1,4,8-triazatricyclo[7.4.0.0^{2,7}]trideca-2(7),8-dien-4-yl]-2-(2-ethyl-6-methyl-pyridin-3-yl)oxy-ethanone, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2023-02-13
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.86633706 Å)
Cite:Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJM
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BU of 8cjm by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-047
Descriptor: 7-(cyclobutylmethyl)-3-ethyl-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2023-02-13
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJI
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BU of 8cji by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-052
Descriptor: FE (III) ION, Tryptophan 5-hydroxylase 1, methyl (2~{S})-2-azanyl-3-[[3-[[3-ethyl-2,6-bis(oxidanylidene)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purin-7-yl]methyl]phenyl]carbonylamino]propanoate
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2023-02-13
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJN
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BU of 8cjn by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-070
Descriptor: 3-ethyl-7-[(4-phenylphenyl)methyl]-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2023-02-13
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.68080938 Å)
Cite:Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJJ
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BU of 8cjj by Molmil
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-057
Descriptor: 3-ethyl-7-(phenylmethyl)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2023-02-13
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.66415656 Å)
Cite:Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
8CJK
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Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-098
Descriptor: 3-ethyl-8-[(2-methylimidazo[2,1-b][1,3]thiazol-6-yl)methyl]-7-[[4-(1-methylpyrazol-3-yl)phenyl]methyl]purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1
Authors:Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U.
Deposit date:2023-02-13
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.45914972 Å)
Cite:Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors.
J.Med.Chem., 66, 2023
2MVX
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BU of 2mvx by Molmil
Atomic-resolution 3D structure of amyloid-beta fibrils: the Osaka mutation
Descriptor: Amyloid beta A4 protein
Authors:Schuetz, A.K, Vagt, T, Huber, M, Ovchinnikova, O.Y, Cadalbert, R, Wall, J, Guentert, P, Bockmann, A, Glockshuber, R, Meier, B.H.
Deposit date:2014-10-17
Release date:2014-11-26
Last modified:2024-05-01
Method:SOLID-STATE NMR
Cite:Atomic-Resolution Three-Dimensional Structure of Amyloid beta Fibrils Bearing the Osaka Mutation.
Angew.Chem.Int.Ed.Engl., 54, 2015
2PSW
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BU of 2psw by Molmil
Human MAK3 homolog in complex with CoA
Descriptor: COENZYME A, N-acetyltransferase 13
Authors:Walker, J.R, Schuetz, A, Antoshenko, T, Wu, H, Bernstein, G, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2007-05-07
Release date:2007-06-05
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Human MAK3 homolog.
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