2XJ2
| Protein kinase Pim-1 in complex with small molecule inhibitor | 分子名称: | (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 | 著者 | Schulz, M.N, Fanghanel, J, Schafer, M, Badock, V, Briem, H, Boemer, U, Nguyen, D, Husemann, M, Hillig, R.C. | 登録日 | 2010-07-01 | 公開日 | 2011-02-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors Acta Crystallogr.,Sect.D, 67, 2011
|
|
2XJ0
| Protein kinase Pim-1 in complex with fragment-4 from crystallographic fragment screen | 分子名称: | (E)-3-(2-AMINO-PYRIDINE-5YL)-ACRYLIC ACID, PROTO-ONCOGENE SERINE/THREONINE PROTEIN KINASE PIM-1 | 著者 | Schulz, M.N, Fanghanel, J, Schafer, M, Badock, V, Briem, H, Boemer, U, Nguyen, D, Husemann, M, Hillig, R.C. | 登録日 | 2010-07-01 | 公開日 | 2011-02-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors Acta Crystallogr.,Sect.D, 67, 2011
|
|
2XJ1
| Protein kinase Pim-1 in complex with small molecule inibitor | 分子名称: | (2E)-3-(3-{6-[(TRANS-4-AMINOCYCLOHEXYL)AMINO]PYRAZIN-2-YL}PHENYL)PROP-2-ENOIC ACID, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 | 著者 | Schulz, M.N, Fanghanel, J, Schafer, M, Badock, V, Briem, H, Boemer, U, Nguyen, D, Husemann, M, Hillig, R.C. | 登録日 | 2010-07-01 | 公開日 | 2011-02-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors Acta Crystallogr.,Sect.D, 67, 2011
|
|
2XIZ
| Protein kinase Pim-1 in complex with fragment-3 from crystallographic fragment screen | 分子名称: | (E)-PYRIDIN-4-YL-ACRYLIC ACID, PROTO-ONCOGENE SERINE/THREONINE PROTEIN KINASE PIM-1 | 著者 | Schulz, M.N, Fanghanel, J, Schafer, M, Badock, V, Briem, H, Boemer, U, Nguyen, D, Husemann, M, Hillig, R.C. | 登録日 | 2010-07-01 | 公開日 | 2011-02-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors Acta Crystallogr.,Sect.D, 67, 2011
|
|
2XIX
| Protein kinase Pim-1 in complex with fragment-1 from crystallographic fragment screen | 分子名称: | 3,5-DIAMINO-1H-[1,2,4]TRIAZOLE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1 | 著者 | Schulz, M.N, Fanghanel, J, Schafer, M, Badock, V, Briem, H, Boemer, U, Nguyen, D, Husemann, M, Hillig, R.C. | 登録日 | 2010-07-01 | 公開日 | 2011-02-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors Acta Crystallogr.,Sect.D, 67, 2011
|
|
3TPD
| Structure of pHipA, monoclinic form | 分子名称: | CHLORIDE ION, PHOSPHATE ION, Serine/threonine-protein kinase HipA | 著者 | schumacher, M.A, link, T, Brennan, R.G. | 登録日 | 2011-09-07 | 公開日 | 2012-10-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Role of Unusual P Loop Ejection and Autophosphorylation in HipA-Mediated Persistence and Multidrug Tolerance. Cell Rep, 2, 2012
|
|
4MCX
| |
5U1J
| Structure of pNOB8 ParA bound to nonspecific DNA | 分子名称: | DNA (5'-D(*CP*GP*TP*GP*TP*AP*AP*TP*GP*AP*CP*GP*CP*CP*GP*GP*CP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*CP*GP*CP*CP*GP*GP*CP*GP*TP*CP*AP*TP*GP*AP*CP*AP*CP*G)-3'), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Schumacher, M.A. | 登録日 | 2016-11-28 | 公開日 | 2017-04-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structures of partition protein ParA with nonspecific DNA and ParB effector reveal molecular insights into principles governing Walker-box DNA segregation. Genes Dev., 31, 2017
|
|
5KEC
| Structure of K. pneumonia MrkH in its apo state. | 分子名称: | Flagellar brake protein YcgR | 著者 | Schumacher, M. | 登録日 | 2016-06-09 | 公開日 | 2016-08-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.949 Å) | 主引用文献 | to be published:
Structures of K. pneumonia MrkH: dual utilization of the PilZ fold for c-di-GMP and DNA binding by a novel activator of biofilm genes To Be Published
|
|
5KED
| |
6ALX
| |
3MKY
| Structure of SopB(155-323)-18mer DNA complex, I23 form | 分子名称: | DNA (5'-D(*CP*TP*GP*GP*GP*AP*CP*CP*AP*TP*GP*GP*TP*CP*CP*CP*AP*G)-3'), Protein sopB, SULFATE ION | 著者 | Schumacher, M.A, Piro, K, Xu, W. | 登録日 | 2010-04-15 | 公開日 | 2010-05-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes. Nucleic Acids Res., 38, 2010
|
|
1SXI
| Structure of apo transcription regulator B. megaterium | 分子名称: | Glucose-resistance amylase regulator, MAGNESIUM ION | 著者 | Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. | 登録日 | 2004-03-30 | 公開日 | 2004-10-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
|
|
4RS7
| |
3OQN
| Structure of ccpa-hpr-ser46-p-gntr-down cre | 分子名称: | 5'-D(*AP*TP*GP*GP*TP*AP*CP*CP*GP*CP*TP*TP*TP*CP*AP*A)-3', 5'-D(*TP*TP*GP*AP*AP*AP*GP*CP*GP*GP*TP*AP*CP*CP*AP*T)-3', Catabolite control protein A, ... | 著者 | Schumacher, M.A, Sprehe, M, Bartholomae, M, Hillen, W, Brennan, R.G. | 登録日 | 2010-09-03 | 公開日 | 2010-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structures of carbon catabolite protein A-(HPr-Ser46-P) bound to diverse catabolite response element sites reveal the basis for high-affinity binding to degenerate DNA operators. Nucleic Acids Res., 39, 2011
|
|
4RS8
| |
1LIO
| STRUCTURE OF APO T. GONDII ADENOSINE KINASE | 分子名称: | adenosine kinase | 著者 | Schumacher, M.A, Scott, D.M, Mathews, I.I, Ealick, S.E, Brennan, R.G. | 登録日 | 2002-04-17 | 公開日 | 2002-06-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. J.Mol.Biol., 298, 2000
|
|
1BD3
| STRUCTURE OF THE APO URACIL PHOSPHORIBOSYLTRANSFERASE, 2 MUTANT C128V | 分子名称: | PHOSPHATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE | 著者 | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | 登録日 | 1998-05-12 | 公開日 | 1999-05-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
|
|
1RZR
| crystal structure of transcriptional regulator-phosphoprotein-DNA complex | 分子名称: | 5'-D(*CP*TP*GP*AP*AP*AP*GP*CP*GP*CP*TP*AP*AP*CP*AP*G)-3', 5'-D(*CP*TP*GP*TP*TP*AP*GP*CP*GP*CP*TP*TP*TP*CP*AP*G)-3', Glucose-resistance amylase regulator, ... | 著者 | Schumacher, M.A, Allen, G.S, Brennan, R.G. | 登録日 | 2003-12-27 | 公開日 | 2004-10-12 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. Cell(Cambridge,Mass.), 118, 2004
|
|
1BD4
| UPRT-URACIL COMPLEX | 分子名称: | PHOSPHATE ION, URACIL, URACIL PHOSPHORIBOSYLTRANSFERASE | 著者 | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | 登録日 | 1998-05-12 | 公開日 | 1999-05-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
|
|
1SXG
| Structural studies on the apo transcription factor form B. megaterium | 分子名称: | 2-PHENYLAMINO-ETHANESULFONIC ACID, Glucose-resistance amylase regulator | 著者 | Schumacher, M.A, Allen, G.S, Diel, M, Seidel, G, Hillen, W, Brennan, R.G. | 登録日 | 2004-03-30 | 公開日 | 2004-10-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural studies on the apo transcription factor form B. megaterium Cell(Cambridge,Mass.), 118, 2004
|
|
1UPU
| STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V, BOUND TO PRODUCT URIDINE-1-MONOPHOSPHATE (UMP) | 分子名称: | PHOSPHATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE, URIDINE-5'-MONOPHOSPHATE | 著者 | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | 登録日 | 1998-04-16 | 公開日 | 1999-05-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
|
|
1KQ2
| Crystal Structure of an Hfq-RNA Complex | 分子名称: | 5'-R(*AP*UP*UP*UP*UP*UP*G)-3', Host factor for Q beta | 著者 | Schumacher, M.A, Pearson, R.F, Moller, T, Valentin-Hansen, P, Brennan, R.G. | 登録日 | 2002-01-03 | 公開日 | 2002-07-05 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein. EMBO J., 21, 2002
|
|
4LNF
| B. subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of GS-Q | 分子名称: | GLUTAMINE, Glutamine synthetase, MAGNESIUM ION, ... | 著者 | Schumacher, M.A, Chinnam, N, Tonthat, N, Fisher, S, Wray, L. | 登録日 | 2013-07-11 | 公開日 | 2013-11-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.949 Å) | 主引用文献 | Structures of the Bacillus subtilis Glutamine Synthetase Dodecamer Reveal Large Intersubunit Catalytic Conformational Changes Linked to a Unique Feedback Inhibition Mechanism. J.Biol.Chem., 288, 2013
|
|
1UPF
| STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE, MUTANT C128V BOUND TO THE DRUG 5-FLUOROURACIL | 分子名称: | 5-FLUOROURACIL, SULFATE ION, URACIL PHOSPHORIBOSYLTRANSFERASE | 著者 | Schumacher, M.A, Carter, D, Scott, D, Roos, D, Ullman, B, Brennan, R.G. | 登録日 | 1998-06-17 | 公開日 | 1999-06-22 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. EMBO J., 17, 1998
|
|