8AYE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8aye by Molmil](/molmil-images/mine/8aye) | E. coli 70S ribosome bound to thermorubin and fMet-tRNA | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Sanyal, S, Parajuli, N.P, Emmerich, A.G. | Deposit date: | 2022-09-02 | Release date: | 2023-03-01 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (1.96 Å) | Cite: | Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria. Nat Commun, 14, 2023
|
|
8P18
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p18 by Molmil](/molmil-images/mine/8p18) | E167K RF2 on E. coli 70S release complex with UGG (Structure III) | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Pundir, S, Larsson, D.S.D, Selmer, M, Sanyal, S. | Deposit date: | 2023-05-11 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | The compensatory mechanism of a naturally evolved
E167K RF2 counteracting the loss of
RF1 in bacteria To Be Published
|
|
5ADY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ady by Molmil](/molmil-images/mine/5ady) | Cryo-EM structures of the 50S ribosome subunit bound with HflX | Descriptor: | 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L10, ... | Authors: | Zhang, Y, Mandava, C.S, Cao, W, Li, X, Zhang, D, Li, N, Zhang, Y, Zhang, X, Qin, Y, Mi, K, Lei, J, Sanyal, S, Gao, N. | Deposit date: | 2015-08-25 | Release date: | 2015-10-14 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Hflx is a Ribosome Splitting Factor Rescuing Stalled Ribosomes Under Stress Conditions Nat.Struct.Mol.Biol., 22, 2015
|
|
6GFU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gfu by Molmil](/molmil-images/mine/6gfu) | Crystal structure of an ancient sequence-reconstructed Elongation Factor Tu (node 262) | Descriptor: | Elongation Factor Tu, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Majumdar, S, Tarafder, A.D, Ge, X, Kacar, B, Sanyal, S. | Deposit date: | 2018-05-02 | Release date: | 2019-05-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of an ancient sequence-reconstructed Elongation Factor Tu (node 262) To Be Published
|
|
4CSU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4csu by Molmil](/molmil-images/mine/4csu) | Cryo-EM structures of the 50S ribosome subunit bound with ObgE | Descriptor: | 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L11, ... | Authors: | Feng, B, Mandava, C.S, Guo, Q, Wang, J, Cao, W, Li, N, Zhang, Y, Zhang, Y, Wang, Z, Wu, J, Sanyal, S, Lei, J, Gao, N. | Deposit date: | 2014-03-10 | Release date: | 2014-06-04 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Structural and Functional Insights Into the Mode of Action of a Universally Conserved Obg Gtpase. Plos Biol., 12, 2014
|
|
2XEX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2xex by Molmil](/molmil-images/mine/2xex) | crystal structure of Staphylococcus aureus elongation factor G | Descriptor: | CHLORIDE ION, ELONGATION FACTOR G, POTASSIUM ION | Authors: | Chen, Y, Koripella, R.K, Sanyal, S, Selmer, M. | Deposit date: | 2010-05-19 | Release date: | 2010-07-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Staphylococcus Aureus Elongation Factor G - Structure and Analysis of a Target for Fusidic Acid. FEBS J., 277, 2010
|
|
8P16
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p16 by Molmil](/molmil-images/mine/8p16) | E167K RF2 on E. coli 70S release complex with UGG (Structure I) | Descriptor: | 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ... | Authors: | Pundir, S, Larsson, D.S.D, Selmer, M, Sanyal, S. | Deposit date: | 2023-05-11 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | The compensatory mechanism of a naturally evolved
E167K RF2 counteracting the loss of
RF1 in bacteria To Be Published
|
|
8P17
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8p17 by Molmil](/molmil-images/mine/8p17) | E167K RF2 on E. coli 70S release complex with UGG (Structure II) | Descriptor: | 1,4-DIAMINOBUTANE, 16S RNA, 23S rRNA, ... | Authors: | Pundir, S, Larsson, D.S.D, Selmer, M, Sanyal, S. | Deposit date: | 2023-05-11 | Release date: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.78 Å) | Cite: | The compensatory mechanism of a naturally evolved
E167K RF2 counteracting the loss of
RF1 in bacteria To Be Published
|
|
8Q4F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8q4f by Molmil](/molmil-images/mine/8q4f) | Structure of arbekacin bound Escherichia coli 70S ribosome | Descriptor: | 16S rRNA, 23S rRNA, 50S ribosomal protein L16, ... | Authors: | Majumdar, S, Parajuli, N.P, Ge, X, Emmerich, A, Sanyal, S. | Deposit date: | 2023-08-06 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of arbekacin bound Escherichia coli 70S ribosome To be published
|
|
6I8R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6i8r by Molmil](/molmil-images/mine/6i8r) | |
7BV8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7bv8 by Molmil](/molmil-images/mine/7bv8) | Mature 50S ribosomal subunit from RrmJ knock out E.coli strain | Descriptor: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | Authors: | Wang, W, Li, W.Q, Ge, X.L, Yan, K.G, Mandava, C.S, Sanyal, S, Gao, N. | Deposit date: | 2020-04-09 | Release date: | 2020-07-01 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | Loss of a single methylation in 23S rRNA delays 50S assembly at multiple late stages and impairs translation initiation and elongation. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6HTW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6htw by Molmil](/molmil-images/mine/6htw) | |
7BBN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7bbn by Molmil](/molmil-images/mine/7bbn) | |
8BSJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bsj by Molmil](/molmil-images/mine/8bsj) | Giardia Ribosome in PRE-T Classical State (C) | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S25, 40S ribosomal protein S26, ... | Authors: | Majumdar, S, Emmerich, A.G, Sanyal, S. | Deposit date: | 2022-11-25 | Release date: | 2023-03-22 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (6.49 Å) | Cite: | Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Nucleic Acids Res., 51, 2023
|
|
8BTD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8btd by Molmil](/molmil-images/mine/8btd) | Giardia Ribosome in PRE-T Hybrid State (D1) | Descriptor: | 5.8S rRNA, 5S rRNA, Large Subunit rRNA, ... | Authors: | Majumdar, S, Emmerich, A.G, Sanyal, S. | Deposit date: | 2022-11-28 | Release date: | 2023-03-22 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Nucleic Acids Res., 51, 2023
|
|
8BTR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8btr by Molmil](/molmil-images/mine/8btr) | Giardia Ribosome in PRE-T Hybrid State (D2) | Descriptor: | 5.8S rRNA, 5S rRNA, Large Subunit rRNA, ... | Authors: | Majumdar, S, Emmerich, A.G, Sanyal, S. | Deposit date: | 2022-11-29 | Release date: | 2023-03-22 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Nucleic Acids Res., 51, 2023
|
|
8BR8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8br8 by Molmil](/molmil-images/mine/8br8) | Giardia ribosome in POST-T state (A1) | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S25, 40S ribosomal protein S26, ... | Authors: | Majumdar, S, Emmerich, A.G, Sanyal, S. | Deposit date: | 2022-11-22 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Nucleic Acids Res., 51, 2023
|
|
8BRM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8brm by Molmil](/molmil-images/mine/8brm) | Giardia ribosome in POST-T state, no E-site tRNA (A6) | Descriptor: | 5.8S rRNA, 5S rRNA, Large Subunit rRNA, ... | Authors: | Majumdar, S, Emmerich, A.G, Sanyal, S. | Deposit date: | 2022-11-23 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Nucleic Acids Res., 51, 2023
|
|
8BSI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8bsi by Molmil](/molmil-images/mine/8bsi) | Giardia ribosome chimeric hybrid-like GDP+Pi bound state (B1) | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S25, 40S ribosomal protein S26, ... | Authors: | Majumdar, S, Emmerich, A.G, Sanyal, S. | Deposit date: | 2022-11-25 | Release date: | 2023-03-15 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis. Nucleic Acids Res., 51, 2023
|
|
3J9Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3j9z by Molmil](/molmil-images/mine/3j9z) | Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Li, W, Liu, Z, Koripella, R.K, Langlois, R, Sanyal, S, Frank, J. | Deposit date: | 2015-03-27 | Release date: | 2015-07-01 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G. Sci Adv, 1, 2015
|
|
3JA1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ja1 by Molmil](/molmil-images/mine/3ja1) | Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Li, W, Liu, Z, Koripella, R.K, Langlois, R, Sanyal, S, Frank, J. | Deposit date: | 2015-03-30 | Release date: | 2015-07-01 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G. Sci Adv, 1, 2015
|
|
2O0F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2o0f by Molmil](/molmil-images/mine/2o0f) | Docking of the modified RF3 X-ray structure into cryo-EM map of E.coli 70S ribosome bound with RF3 | Descriptor: | Peptide chain release factor 3 | Authors: | Gao, H, Zhou, Z, Rawat, U, Huang, C, Bouakaz, L, Wang, C, Liu, Y, Zavialov, A, Gursky, R, Sanyal, S, Ehrenberg, M, Frank, J, Song, H. | Deposit date: | 2006-11-27 | Release date: | 2007-07-24 | Last modified: | 2023-12-27 | Method: | ELECTRON MICROSCOPY (15.5 Å) | Cite: | RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors Cell(Cambridge,Mass.), 129, 2007
|
|
4ADN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4adn by Molmil](/molmil-images/mine/4adn) | Fusidic acid resistance protein FusB | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FAR1, ... | Authors: | Guo, X, Peisker, K, Backbro, K, Chen, Y, Kiran, R.K, Sanyal, S, Selmer, M. | Deposit date: | 2011-12-31 | Release date: | 2012-03-07 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and Function of Fusb: An Elongation Factor G-Binding Fusidic Acid Resistance Protein Active in Ribosomal Translocation and Recycling Open Biol., 2, 2012
|
|
4ADO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ado by Molmil](/molmil-images/mine/4ado) | Fusidic acid resistance protein FusB | Descriptor: | FAR1, ZINC ION | Authors: | Guo, X, Peisker, K, Backbro, K, Chen, Y, Kiran, R.K, Sanyal, S, Selmer, M. | Deposit date: | 2011-12-31 | Release date: | 2012-03-07 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and Function of Fusb: An Elongation Factor G-Binding Fusidic Acid Resistance Protein Active in Ribosomal Translocation and Recycling Open Biol., 2, 2012
|
|
3ZZ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3zz0 by Molmil](/molmil-images/mine/3zz0) | |