5BSU
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![BU of 5bsu by Molmil](/molmil-images/mine/5bsu) | Crystal structure of 4-coumarate:CoA ligase complexed with caffeoyl adenylate | Descriptor: | 4-coumarate--CoA ligase 2, 5'-O-[(R)-{[(2E)-3-(3,4-dioxocyclohexa-1,5-dien-1-yl)prop-2-enoyl]oxy}(hydroxy)phosphoryl]adenosine, GLYCEROL, ... | Authors: | Li, Z, Nair, S.K. | Deposit date: | 2015-06-02 | Release date: | 2016-05-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis for Specificity and Flexibility in a Plant 4-Coumarate:CoA Ligase. Structure, 23, 2015
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1T49
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![BU of 1t49 by Molmil](/molmil-images/mine/1t49) | Allosteric Inhibition of Protein Tyrosine Phosphatase 1B | Descriptor: | 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID (4-SULFAMOYL-PHENYL)-AMIDE, MAGNESIUM ION, Protein-tyrosine phosphatase, ... | Authors: | Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K. | Deposit date: | 2004-04-28 | Release date: | 2004-07-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Allosteric inhibition of protein tyrosine phosphatase 1B. Nat.Struct.Mol.Biol., 11, 2004
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1YZ2
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![BU of 1yz2 by Molmil](/molmil-images/mine/1yz2) | Solution structure of Am2766 | Descriptor: | Delta-conotoxin Am 2766 | Authors: | Sarma, S.P, Kumar, G.S, Sudarslal, S, Iengar, P, Sikdar, S.K, Krishnan, K.S, Balaram, P. | Deposit date: | 2005-02-26 | Release date: | 2006-02-07 | Last modified: | 2019-11-06 | Method: | SOLUTION NMR | Cite: | Solution Structure of delta-Am2766: A Highly Hydrophobic delta-Conotoxin from Conus amadis That Inhibits Inactivation of Neuronal Voltage-Gated Sodium Channels CHEM.BIODIVERS., 2, 2005
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6GJE
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![BU of 6gje by Molmil](/molmil-images/mine/6gje) | Structure of the Amnionless(20-357)-Cubilin(36-135) complex | Descriptor: | Cubilin, Protein amnionless | Authors: | Larsen, C, Etzerodt, A, Madsen, M, Skjoedt, K, Moestrup, S.K, Andersen, C.B.F. | Deposit date: | 2018-05-16 | Release date: | 2018-12-19 | Last modified: | 2019-06-12 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural assembly of the megadalton-sized receptor for intestinal vitamin B12uptake and kidney protein reabsorption. Nat Commun, 9, 2018
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1ZAU
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![BU of 1zau by Molmil](/molmil-images/mine/1zau) | |
3Q7M
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![BU of 3q7m by Molmil](/molmil-images/mine/3q7m) | |
3Q7N
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![BU of 3q7n by Molmil](/molmil-images/mine/3q7n) | |
3QD3
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![BU of 3qd3 by Molmil](/molmil-images/mine/3qd3) | Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl {(3R,6S)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate | Descriptor: | 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... | Authors: | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | Deposit date: | 2011-01-17 | Release date: | 2011-03-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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3QKC
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![BU of 3qkc by Molmil](/molmil-images/mine/3qkc) | CRYSTAL STRUCTURE OF geranyl diphosphate synthase small subunit from Antirrhinum majus | Descriptor: | Geranyl diphosphate synthase small subunit | Authors: | Malashkevich, V.N, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2011-01-31 | Release date: | 2011-02-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of geranyl diphosphate synthase small subunit from Antirrhinum majus To be Published
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1ZYC
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![BU of 1zyc by Molmil](/molmil-images/mine/1zyc) | Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type in Apo Form. | Descriptor: | Serine/threonine-protein kinase GCN2 | Authors: | Padyana, A.K, Qiu, H, Roll-Mecak, A, Hinnebusch, A.G, Burley, S.K. | Deposit date: | 2005-06-09 | Release date: | 2005-06-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2 J.Biol.Chem., 280, 2005
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1ZY4
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![BU of 1zy4 by Molmil](/molmil-images/mine/1zy4) | Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form. | Descriptor: | GLYCEROL, Serine/threonine-protein kinase GCN2 | Authors: | Padyana, A.K, Qiu, H, Roll-Mecak, A, Hinnebusch, A.G, Burley, S.K. | Deposit date: | 2005-06-09 | Release date: | 2005-06-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Basis for Autoinhibition and Mutational Activation of Eukaryotic Initiation Factor 2{alpha} Protein Kinase GCN2 J.Biol.Chem., 280, 2005
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1ZZW
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![BU of 1zzw by Molmil](/molmil-images/mine/1zzw) | Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5 | Descriptor: | 1,2-ETHANEDIOL, Dual specificity protein phosphatase 10, SULFATE ION | Authors: | Jeong, D.G, Yoon, T.S, Kim, J.H, Shim, M.Y, Jeong, S.K, Son, J.H, Ryu, S.E, Kim, S.J. | Deposit date: | 2005-06-14 | Release date: | 2006-07-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of the Catalytic Domain of Human MAP Kinase Phosphatase 5: Structural Insight into Constitutively Active Phosphatase. J.Mol.Biol., 360, 2006
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3R95
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![BU of 3r95 by Molmil](/molmil-images/mine/3r95) | |
3R9F
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![BU of 3r9f by Molmil](/molmil-images/mine/3r9f) | |
5DA3
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![BU of 5da3 by Molmil](/molmil-images/mine/5da3) | Crystal structure of PTK6 Kinase domain with inhibitor | Descriptor: | (2-chloro-4-{[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone, GLYCEROL, Protein-tyrosine kinase 6 | Authors: | Thakur, M.K, Birudukota, S, Swaminathan, S, Battula, S.K, Vadivelu, S, Tyagi, R, Gosu, R. | Deposit date: | 2015-08-19 | Release date: | 2016-08-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution Biochem. Biophys. Res. Commun., 482, 2017
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1T48
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![BU of 1t48 by Molmil](/molmil-images/mine/1t48) | Allosteric Inhibition of Protein Tyrosine Phosphatase 1B | Descriptor: | 3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC ACID DIMETHYLAMIDE, Protein-tyrosine phosphatase, non-receptor type 1 | Authors: | Wiesmann, C, Barr, K.J, Kung, J, Zhu, J, Shen, W, Fahr, B.J, Zhong, M, Erlanson, D.A, Taylor, L, Randal, M, McDowell, R.S, Hansen, S.K. | Deposit date: | 2004-04-28 | Release date: | 2004-07-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Allosteric inhibition of protein tyrosine phosphatase 1B Nat.Struct.Mol.Biol., 11, 2004
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3WRS
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![BU of 3wrs by Molmil](/molmil-images/mine/3wrs) | |
1YW2
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![BU of 1yw2 by Molmil](/molmil-images/mine/1yw2) | Mutated Mus Musculus P38 Kinase (mP38) | Descriptor: | 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE, Mitogen-activated protein kinase 14 | Authors: | Laughlin, S.K, Clark, M.P, Djung, J.F, Golebiowski, A, Brugel, T.A, Sabat, M, Bookland, R.G, Laufersweiler, M.J, Vanrens, J.C, Townes, J.A, De, B, Hsieh, L.C, Xu, S.C, Walter, R.L, Mekel, M.J, Janusz, M.J. | Deposit date: | 2005-02-16 | Release date: | 2005-05-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production. Bioorg.Med.Chem.Lett., 15, 2005
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3WRQ
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3WRR
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![BU of 3wrr by Molmil](/molmil-images/mine/3wrr) | |
3TLY
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![BU of 3tly by Molmil](/molmil-images/mine/3tly) | |
2HDF
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![BU of 2hdf by Molmil](/molmil-images/mine/2hdf) | |
3U0O
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![BU of 3u0o by Molmil](/molmil-images/mine/3u0o) | The crystal structure of selenophosphate synthetase from E. coli | Descriptor: | MAGNESIUM ION, Selenide, water dikinase | Authors: | Noinaj, N, Wattanasak, R, Wally, J, Stadtman, T, Buchanan, S.K. | Deposit date: | 2011-09-28 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural insights into the catalytic mechanism of Escherichia coli selenophosphate synthetase. J.Bacteriol., 194, 2012
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3QD4
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![BU of 3qd4 by Molmil](/molmil-images/mine/3qd4) | Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate | Descriptor: | 3-phosphoinositide-dependent protein kinase 1, SULFATE ION, tert-butyl {(3R,5R)-1-[2-amino-6-(3-amino-2H-indazol-6-yl)pyrimidin-4-yl]-5-methylpiperidin-3-yl}carbamate | Authors: | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | Deposit date: | 2011-01-17 | Release date: | 2011-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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3QCS
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![BU of 3qcs by Molmil](/molmil-images/mine/3qcs) | Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with 6-[2-Amino-6-(4-morpholinyl)-4-pyrimidinyl]-1H-indazol-3-amine | Descriptor: | 3-phosphoinositide-dependent protein kinase 1, 6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2H-indazol-3-amine, GLYCEROL, ... | Authors: | Medina, J.R, Becker, C.J, Blackledge, C.W, Duquenne, C, Feng, Y, Grant, S.W, Heerding, D, Li, W.H, Miller, W.H, Romeril, S.P, Scherzer, D, Shu, A, Bobko, M.A, Chadderton, A.R, Dumble, M, Gradiner, C.M, Gilbert, S, Liu, Q, Rabindran, S.K, Sudakin, V, Xiang, H, Brady, P.G, Campobasso, N, Ward, P, Axten, J.M. | Deposit date: | 2011-01-17 | Release date: | 2011-03-09 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.487 Å) | Cite: | Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors. J.Med.Chem., 54, 2011
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