4YCA
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![BU of 4yca by Molmil](/molmil-images/mine/4yca) | Evidence of Kinetic Cooperativity in dimeric Ketopantoate Reductase from Staphylococcus aureus | Descriptor: | 2-dehydropantoate 2-reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Sanchez, J.E, Gross, P.G, Goetze, R, Walsh Jr, R.M, Peeples, W.B, Wood, Z.A. | Deposit date: | 2015-02-19 | Release date: | 2015-03-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Evidence of Kinetic Cooperativity in Dimeric Ketopantoate Reductase from Staphylococcus aureus. Biochemistry, 54, 2015
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7MZY
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![BU of 7mzy by Molmil](/molmil-images/mine/7mzy) | Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986 | Descriptor: | ACETATE ION, ALK tyrosine kinase receptor | Authors: | Reshetnyak, A.V, Sowaileh, M, Miller, D.J, Rossi, P, Myasnikov, A.G, Kalodimos, C.G. | Deposit date: | 2021-05-24 | Release date: | 2021-11-24 | Last modified: | 2021-12-15 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 600, 2021
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5JTN
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![BU of 5jtn by Molmil](/molmil-images/mine/5jtn) | The structure of chaperone SecB in complex with unstructured proPhoA binding site c | Descriptor: | Alkaline phosphatase, Protein-export protein SecB | Authors: | Huang, C, Saio, T, Rossi, P, Kalodimos, C.G. | Deposit date: | 2016-05-09 | Release date: | 2016-08-24 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for the antifolding activity of a molecular chaperone. Nature, 537, 2016
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5JTL
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![BU of 5jtl by Molmil](/molmil-images/mine/5jtl) | The structure of chaperone SecB in complex with unstructured proPhoA | Descriptor: | Alkaline phosphatase, Protein-export protein SecB | Authors: | Huang, C, Saio, T, Rossi, P, Kalodimos, C.G. | Deposit date: | 2016-05-09 | Release date: | 2016-08-24 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for the antifolding activity of a molecular chaperone. Nature, 537, 2016
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5JTM
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![BU of 5jtm by Molmil](/molmil-images/mine/5jtm) | The structure of chaperone SecB in complex with unstructured PhoA binding site a | Descriptor: | Alkaline phosphatase, Protein-export protein SecB | Authors: | Huang, C, Saio, T, Rossi, P, Kalodimos, C.G. | Deposit date: | 2016-05-09 | Release date: | 2016-08-24 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for the antifolding activity of a molecular chaperone. Nature, 537, 2016
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5JTQ
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![BU of 5jtq by Molmil](/molmil-images/mine/5jtq) | The structure of chaperone SecB in complex with unstructured MBP binding site d | Descriptor: | Maltose-binding periplasmic protein, Protein-export protein SecB | Authors: | Huang, C, Saio, T, Rossi, P, Kalodimos, C.G. | Deposit date: | 2016-05-09 | Release date: | 2016-08-24 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for the antifolding activity of a molecular chaperone. Nature, 537, 2016
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5JTO
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![BU of 5jto by Molmil](/molmil-images/mine/5jto) | The structure of chaperone SecB in complex with unstructured proPhoA binding site d | Descriptor: | Alkaline phosphatase, Protein-export protein SecB | Authors: | Huang, C, Saio, T, Rossi, P, Kalodimos, C.G. | Deposit date: | 2016-05-09 | Release date: | 2016-08-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis for the antifolding activity of a molecular chaperone. Nature, 537, 2016
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5JTP
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![BU of 5jtp by Molmil](/molmil-images/mine/5jtp) | The structure of chaperone SecB in complex with unstructured proPhoA binding site e | Descriptor: | Alkaline phosphatase, Protein-export protein SecB | Authors: | Huang, C, Saio, T, Rossi, P, Kalodimos, C.G. | Deposit date: | 2016-05-09 | Release date: | 2016-08-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis for the antifolding activity of a molecular chaperone. Nature, 537, 2016
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5JTR
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![BU of 5jtr by Molmil](/molmil-images/mine/5jtr) | The structure of chaperone SecB in complex with unstructured MBP binding site e | Descriptor: | Maltose-binding periplasmic protein, Protein-export protein SecB | Authors: | Huang, C, Saio, T, Rossi, P, Kalodimos, C.G. | Deposit date: | 2016-05-09 | Release date: | 2016-08-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis for the antifolding activity of a molecular chaperone. Nature, 537, 2016
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5KP0
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![BU of 5kp0 by Molmil](/molmil-images/mine/5kp0) | Recognition and targeting mechanisms by chaperones in flagella assembly and operation | Descriptor: | Flagellar protein FliT,Flagellum-specific ATP synthase | Authors: | Khanra, N.K, Rossi, P, Economou, A, Kalodimos, C.G. | Deposit date: | 2016-07-01 | Release date: | 2016-08-17 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Recognition and targeting mechanisms by chaperones in flagellum assembly and operation. Proc.Natl.Acad.Sci.USA, 113, 2016
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5KS6
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![BU of 5ks6 by Molmil](/molmil-images/mine/5ks6) | |
2Z4O
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![BU of 2z4o by Molmil](/molmil-images/mine/2z4o) | Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-98065 | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(2S,3R)-3-HYDROXY-4-(N-ISOBUTYLBENZO[D][1,3]DIOXOLE-5-SULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE, ACETATE ION, CHLORIDE ION, ... | Authors: | Wang, Y.F, Tie, Y, Boross, P.I, Tozser, J, Ghosh, A.K, Harrison, R.W, Weber, I.T. | Deposit date: | 2007-06-20 | Release date: | 2008-04-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J.Med.Chem., 50, 2007
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1SDT
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![BU of 1sdt by Molmil](/molmil-images/mine/1sdt) | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. | Descriptor: | CHLORIDE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, protease RETROPEPSIN | Authors: | Mahalingam, B, Wang, Y.-F, Boross, P.I, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T. | Deposit date: | 2004-02-14 | Release date: | 2004-05-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structures of HIV protease V82A and L90M
mutants reveal changes in the indinavir-binding site Eur.J.Biochem., 271, 2004
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1SDU
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![BU of 1sdu by Molmil](/molmil-images/mine/1sdu) | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. | Descriptor: | ACETATE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, SULFATE ION, ... | Authors: | Mahalingam, B, Wang, Y.-F, Boross, P.I, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T. | Deposit date: | 2004-02-14 | Release date: | 2004-05-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Crystal structures of HIV protease V82A and L90M
mutants reveal changes in the indinavir-binding site Eur.J.Biochem., 271, 2004
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7N00
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![BU of 7n00 by Molmil](/molmil-images/mine/7n00) | Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha | Descriptor: | ALK and LTK ligand 2, ALK tyrosine kinase receptor | Authors: | Reshetnyak, A.V, Myasnikov, A.G, Rossi, P, Miller, D.J, Kalodimos, C.G. | Deposit date: | 2021-05-24 | Release date: | 2021-11-24 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.27 Å) | Cite: | Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 600, 2021
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6XR6
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![BU of 6xr6 by Molmil](/molmil-images/mine/6xr6) | |
6XR7
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![BU of 6xr7 by Molmil](/molmil-images/mine/6xr7) | |
6XRG
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![BU of 6xrg by Molmil](/molmil-images/mine/6xrg) | |
1SDV
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![BU of 1sdv by Molmil](/molmil-images/mine/1sdv) | Crystal structures of HIV protease V82A and L90M mutants reveal changes in indinavir binding site. | Descriptor: | CHLORIDE ION, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, protease RETROPEPSIN | Authors: | Mahalingam, B, Wang, Y.-F, Boross, P.I, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T. | Deposit date: | 2004-02-14 | Release date: | 2004-05-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structures of HIV protease V82A and L90M
mutants reveal changes in the indinavir-binding site Eur.J.Biochem., 271, 2004
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2AOJ
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![BU of 2aoj by Molmil](/molmil-images/mine/2aoj) | Crystal structure analysis of HIV-1 protease with a substrate analog P6-PR | Descriptor: | ACETIC ACID, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-12 | Release date: | 2006-01-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. Febs J., 272, 2005
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2AVO
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![BU of 2avo by Molmil](/molmil-images/mine/2avo) | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S | Descriptor: | ACETIC ACID, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Liu, F, Boross, P.I, Wang, Y.F, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-30 | Release date: | 2006-01-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J.Mol.Biol., 354, 2005
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2AVQ
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![BU of 2avq by Molmil](/molmil-images/mine/2avq) | Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ... | Authors: | Liu, F, Boross, P.I, Wang, Y.F, Tozser, J, Louis, J.M, Harrison, R.W, Weber, I.T. | Deposit date: | 2005-08-30 | Release date: | 2006-01-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J.Mol.Biol., 354, 2005
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1MMI
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![BU of 1mmi by Molmil](/molmil-images/mine/1mmi) | E. COLI DNA POLYMERASE BETA SUBUNIT | Descriptor: | DNA polymerase III, beta chain | Authors: | Oakley, A.J, Prosselkov, P, Wijffels, G, Beck, J.L, Wilce, M.C.J, Dixon, N.E. | Deposit date: | 2002-09-04 | Release date: | 2003-09-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.848 Å) | Cite: | Flexibility revealed by the 1.85 A crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III. Acta Crystallogr.,Sect.D, 59, 2003
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2KEM
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![BU of 2kem by Molmil](/molmil-images/mine/2kem) | Extended structure of citidine deaminase domain of APOBEC3G | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | Authors: | Harjes, E, Gross, P.J, Chen, K, Lu, Y, Shindo, K, Nowarski, R, Gross, J.D, Kotler, M, Harris, R.S, Matsuo, H. | Deposit date: | 2009-01-30 | Release date: | 2009-06-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model J.Mol.Biol., 389, 2009
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3QSB
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![BU of 3qsb by Molmil](/molmil-images/mine/3qsb) | Structure of E. coli polIIIbeta with (Z)-5-(1-((4'-Fluorobiphenyl-4-yl)methoxyimino)butyl)-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile | Descriptor: | (1R,5R)-5-{(1Z)-N-[(4'-fluorobiphenyl-4-yl)methoxy]butanimidoyl}-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile, DNA polymerase III subunit beta | Authors: | Wijffels, G, Johnson, W.M, Oakley, A.J, Turner, K, Epa, V.C, Briscoe, S.J, Polley, M, Liepa, A.J, Hofmann, A, Buchardt, J, Christensen, C, Prosselkov, P, Dalrymple, B.P, Alewood, P.F, Jennings, P.A, Dixon, N.E, Winkler, D.A. | Deposit date: | 2011-02-20 | Release date: | 2011-06-08 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Binding inhibitors of the bacterial sliding clamp by design J.Med.Chem., 54, 2011
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