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PDB: 119 results

4P54
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BU of 4p54 by Molmil
Crystal Structure of the Helicobacter pylori MTAN-D198N mutant with 5'-methylthioadenosine in the active site.
Descriptor: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Aminodeoxyfutalosine nucleosidase, CHLORIDE ION
Authors:Ronning, D.R, Mishra, V.
Deposit date:2014-03-14
Release date:2014-04-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding subsite.
Biochemistry, 51, 2012
1DQZ
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BU of 1dqz by Molmil
CRYSTAL STRUCTURE OF ANTIGEN 85C FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor: PROTEIN (ANTIGEN 85-C)
Authors:Ronning, D.R, Klabunde, T, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2000-01-05
Release date:2000-07-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
Nat.Struct.Biol., 7, 2000
1DQY
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BU of 1dqy by Molmil
CRYSTAL STRUCTURE OF ANTIGEN 85C FROM MYCOBACTERIUM TUBERCULOSIS WITH DIETHYL PHOSPHATE INHIBITOR
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, DIETHYL PHOSPHONATE, PROTEIN (ANTIGEN 85-C)
Authors:Ronning, D.R, Klabunde, T, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2000-01-05
Release date:2000-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.
Nat.Struct.Biol., 7, 2000
3NM5
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BU of 3nm5 by Molmil
Helicobacter pylori MTAN complexed with Formycin A
Descriptor: (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, MTA/SAH nucleosidase
Authors:Ronning, D.R, Iacopelli, N.M.
Deposit date:2010-06-21
Release date:2010-11-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
3NM4
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BU of 3nm4 by Molmil
Helicobacter pylori MTAN
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MTA/SAH nucleosidase
Authors:Ronning, D.R, Iacopelli, N.M.
Deposit date:2010-06-21
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
3NM6
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BU of 3nm6 by Molmil
Helicobacter pylori MTAN complexed with adenine and tris
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENINE, ...
Authors:Ronning, D.R, Iacopelli, N.M.
Deposit date:2010-06-21
Release date:2010-11-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Protein Sci., 19, 2010
2A6O
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BU of 2a6o by Molmil
Crystal Structure of the ISHp608 Transposase in Complex with Stem-loop DNA
Descriptor: 5'-D(*CP*CP*CP*CP*TP*AP*GP*CP*TP*TP*TP*AP*GP*CP*TP*AP*TP*GP*GP*GP*GP*A)-3', ISHp608 Transposase
Authors:Ronning, D.R, Guynet, C, Ton-Hoang, B, Perez, Z.N, Ghirlando, R, Chandler, M, Dyda, F.
Deposit date:2005-07-03
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Active site sharing and subterminal hairpin recognition in a new class of DNA transposases.
Mol.Cell, 20, 2005
1VA5
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BU of 1va5 by Molmil
Antigen 85C with octylthioglucoside in active site
Descriptor: Antigen 85-C, octyl 1-thio-beta-D-glucopyranoside
Authors:Ronning, D.R, Vissa, V, Besra, G.S, Belisle, J.T, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-02-11
Release date:2004-07-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Mycobacterium tuberculosis Antigen 85A and 85C Structures Confirm Binding Orientation and Conserved Substrate Specificity
J.Biol.Chem., 279, 2004
1T0F
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BU of 1t0f by Molmil
Crystal Structure of the TnsA/TnsC(504-555) complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, MALONIC ACID, ...
Authors:Ronning, D.R, Li, Y, Perez, Z.N, Ross, P.D, Hickman, A.B, Craig, N.L, Dyda, F.
Deposit date:2004-04-08
Release date:2004-11-09
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA.
Embo J., 23, 2004
2A6M
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BU of 2a6m by Molmil
Crystal Structure of the ISHp608 Transposase
Descriptor: ISHp608 transposase
Authors:Ronning, D.R, Guynet, C, Ton-Hoang, B, Perez, Z.N, Ghirlando, R, Chandler, M, Dyda, F.
Deposit date:2005-07-03
Release date:2005-10-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Active site sharing and subterminal hairpin recognition in a new class of DNA transposases.
Mol.Cell, 20, 2005
1SFR
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BU of 1sfr by Molmil
Crystal Structure of the Mycobacterium tuberculosis Antigen 85A Protein
Descriptor: Antigen 85-A
Authors:Ronning, D.R, Vissa, V, Besra, G.S, Belisle, J.T, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-02-20
Release date:2004-07-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mycobacterium tuberculosis Antigen 85A and 85C Structures Confirm Binding Orientation and Conserved Substrate Specificity
J.Biol.Chem., 279, 2004
4U3C
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BU of 4u3c by Molmil
Docking Site of Maltohexaose in the Mtb GlgE
Descriptor: Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Ronning, D.R, Lindenberger, J.J.
Deposit date:2014-07-19
Release date:2015-07-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.98 Å)
Cite:Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
Sci Rep, 5, 2015
4U2Z
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BU of 4u2z by Molmil
X-ray crystal structure of an Sco GlgEI-V279S/1,2,2-trifluromaltose complex
Descriptor: Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1, alpha-D-glucopyranose-(1-4)-2-deoxy-2,2-difluoro-alpha-D-arabino-hexopyranosyl fluoride
Authors:Ronning, D.R, Lindenberger, J.J.
Deposit date:2014-07-18
Release date:2015-07-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Synthesis of 2-deoxy-2,2-difluoro-alpha-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S.
Org.Biomol.Chem., 13, 2015
4U31
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BU of 4u31 by Molmil
Sco GlgEI-V279S in Complex with maltose-C-phosphonate
Descriptor: 1,2-ETHANEDIOL, Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1, CITRIC ACID, ...
Authors:Ronning, D.R, Lindenberger, J.J.
Deposit date:2014-07-18
Release date:2015-07-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
Sci Rep, 5, 2015
4U33
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BU of 4u33 by Molmil
Structure of Mtb GlgE bound to maltose
Descriptor: Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Ronning, D.R, Lindenberger, J.J.
Deposit date:2014-07-18
Release date:2015-07-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.293 Å)
Cite:Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
Sci Rep, 5, 2015
4U2Y
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BU of 4u2y by Molmil
Sco GlgEI-V279S in Complex with Reaction Intermediate Azasugar
Descriptor: (2R,3R,4R,5R)-4-hydroxy-2,5-bis(hydroxymethyl)pyrrolidin-3-yl alpha-D-glucopyranoside, Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase 1
Authors:Ronning, D.R, Lindenberger, J.J.
Deposit date:2014-07-18
Release date:2015-08-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.483 Å)
Cite:Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors.
Sci Rep, 5, 2015
1MTO
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BU of 1mto by Molmil
Crystal structure of a Phosphofructokinase mutant from Bacillus stearothermophilus bound with fructose-6-phosphate
Descriptor: 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructokinase
Authors:Riley-Lovingshimer, M.R, Ronning, D.R, Sacchettini, J.C, Reinhart, G.D.
Deposit date:2002-09-21
Release date:2002-12-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Reversible Ligand-Induced Dissociation of a Tryptophan-Shift Mutant of Phosphofructokinase from Bacillus stearothermophilus
Biochemistry, 41, 2002
5WAT
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BU of 5wat by Molmil
Corynebacterium glutamicum Full length Homoserine kinase
Descriptor: HEXAETHYLENE GLYCOL, Homoserine kinase, MAGNESIUM ION, ...
Authors:Petit, C, Ronning, D.R.
Deposit date:2017-06-27
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.141 Å)
Cite:Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis.
ACS Omega, 3, 2018
7SEX
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BU of 7sex by Molmil
M. tb EgtD in complex with TGX221
Descriptor: 7-methyl-2-morpholin-4-yl-9-[(1~{R})-1-phenylazanylethyl]-3~{H}-pyrido[1,2-a]pyrimidin-4-one, GLYCEROL, Histidine N-alpha-methyltransferase
Authors:Sudasinghe, T.D, Ronning, D.R.
Deposit date:2021-10-02
Release date:2021-12-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production.
Sci Rep, 11, 2021
7SEW
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BU of 7sew by Molmil
M. tb EgtD in complex with HD6
Descriptor: 1,3-PROPANDIOL, GLYCEROL, Histidine N-alpha-methyltransferase, ...
Authors:Sudasinghe, T.D, Ronning, D.R.
Deposit date:2021-10-02
Release date:2021-12-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production.
Sci Rep, 11, 2021
7SF5
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BU of 7sf5 by Molmil
M. tb EgtD in complex with HD3
Descriptor: Histidine N-alpha-methyltransferase, N-(benzylcarbamothioyl)-L-histidine
Authors:Sudasinghe, T.D, Ronning, D.R.
Deposit date:2021-10-03
Release date:2021-12-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production.
Sci Rep, 11, 2021
7SF4
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BU of 7sf4 by Molmil
M. tb EgtD in complex with imatinib
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-4-PYRIDYL-PYRIMIDINE, GLYCEROL, ...
Authors:Sudasinghe, T.D, Ronning, D.R.
Deposit date:2021-10-03
Release date:2021-12-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production.
Sci Rep, 11, 2021
7SCF
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BU of 7scf by Molmil
M. tb EgtD in complex with HD2
Descriptor: (2S)-3-(1H-imidazol-5-yl)-2-(1H-pyrrol-1-yl)propanoic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Sudasinghe, T.D, Ronning, D.R.
Deposit date:2021-09-28
Release date:2021-12-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production.
Sci Rep, 11, 2021
7SEY
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BU of 7sey by Molmil
M. tb EgtD in complex with SGH
Descriptor: 2-amino-1-[(3S)-3-methyl-4-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepan-1-yl]ethan-1-one, Histidine N-alpha-methyltransferase
Authors:Sudasinghe, T.D, Ronning, D.R.
Deposit date:2021-10-02
Release date:2021-12-01
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production.
Sci Rep, 11, 2021
7MYG
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BU of 7myg by Molmil
M. tb Ag85C modified by THL-10d
Descriptor: Diacylglycerol acyltransferase, GLYCEROL
Authors:Sudasinghe, T.D, Ronning, D.R.
Deposit date:2021-05-21
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Total Synthesis of Tetrahydrolipstatin, Its Derivatives, and Evaluation of Their Ability to Potentiate Multiple Antibiotic Classes against Mycobacterium Species.
Acs Infect Dis., 7, 2021

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