4G1Z
 
 | | Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor | | Descriptor: | 3-(5'-{[3,4-bis(hydroxymethyl)benzyl]oxy}-2'-ethyl-2-propylbiphenyl-4-yl)pentan-3-ol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | | Authors: | Ciesielski, F, Sato, Y, Moras, D, Rochel, N. | | Deposit date: | 2012-07-11 | | Release date: | 2012-09-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor.
J.Med.Chem., 55, 2012
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4DM8
 | | Crystal structure of RARb LBD in complex with 9cis retinoic acid | | Descriptor: | Nuclear receptor coactivator 1, RETINOIC ACID, Retinoic acid receptor beta | | Authors: | Osz, J, Br livet, Y, Peluso-Iltis, C, Cura, V, Eiler, S, Ruff, M, Bourguet, W, Rochel, N, Moras, D. | | Deposit date: | 2012-02-07 | | Release date: | 2012-03-07 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.
Proc.Natl.Acad.Sci.USA, 109, 2012
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9GFE
 | | hRAR LBD protein in complex with AM580 agonist ligand and a stapled peptide | | Descriptor: | 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid, Retinoic acid receptor alpha, Stapled peptide-like ligand | | Authors: | Perdriau, C, Luton, A, Zimmeter, K, Neuville, M, Saragaglia, C, Peluso-lltis, C, Kauffmann, B, Collie, G, Rochel, N, Guichard, G, Pasco, M. | | Deposit date: | 2024-08-09 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-05 | | Method: | X-RAY DIFFRACTION (1.583 Å) | | Cite: | Guanidinium-Stapled Helical Peptides for Targeting Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 64, 2025
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4DMA
 | | Crystal structure of ERa LBD in complex with RU100132 | | Descriptor: | 2'-bromo-6'-(furan-3-yl)-4'-(hydroxymethyl)biphenyl-4-ol, Estrogen receptor, Nuclear receptor coactivator 1 | | Authors: | Osz, J, Brelivet, Y, Peluso-Iltis, C, Cura, V, Eiler, S, Ruff, M, Bourguet, W, Rochel, N, Moras, D. | | Deposit date: | 2012-02-07 | | Release date: | 2012-03-07 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.
Proc.Natl.Acad.Sci.USA, 109, 2012
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9GFI
 | | hRAR alpha LBD-AM580 complex with staple peptide | | Descriptor: | 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid, Retinoic acid receptor alpha, Stapled peptide-like ligand | | Authors: | Perdriau, C, Luton, A, Zimmeter, K, Neuville, M, Saragaglia, C, Peluso-lltis, C, Osz, J, Kauffmann, B, Collie, G, Rochel, N, Guichard, G, Pasco, M. | | Deposit date: | 2024-08-09 | | Release date: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Guanidinium-Stapled Helical Peptides for Targeting Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 64, 2025
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9GF9
 | | S-Protease complexed with stapled peptide-like ligand | | Descriptor: | Ribonuclease pancreatic, SULFATE ION | | Authors: | Perdriau, C, Luton, A, Zimmeter, K, Neuville, M, Saragaglia, C, Peluso-lltis, C, Osz, J, Kauffmann, B, Collie, G, Rochel, N, Guichard, G, Pasco, M. | | Deposit date: | 2024-08-08 | | Release date: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Guanidinium-Stapled Helical Peptides for Targeting Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 64, 2025
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9GFC
 | | HDM2 complexed with stapled peptide-like ligand | | Descriptor: | E3 ubiquitin-protein ligase Mdm2, Stapled peptide-like ligand | | Authors: | Perdriau, C, Luton, A, Zimmeter, K, Neuville, M, Saragaglia, C, Peluso-lltis, C, Osz, J, Kauffmann, B, Collie, G, Rochel, N, Guichard, G, Pasco, M. | | Deposit date: | 2024-08-08 | | Release date: | 2025-02-12 | | Method: | X-RAY DIFFRACTION (2.501 Å) | | Cite: | Guanidinium-Stapled Helical Peptides for Targeting Protein-Protein Interactions.
Angew.Chem.Int.Ed.Engl., 64, 2025
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4G2H
 | | Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor | | Descriptor: | (3E,5E)-6-(3-{2-[3,4-bis(hydroxymethyl)phenyl]ethyl}phenyl)-1,1,1-trifluoro-2-(trifluoromethyl)octa-3,5-dien-2-ol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | | Authors: | Ciesielski, F, Sato, Y, Moras, D, Rochel, N. | | Deposit date: | 2012-07-12 | | Release date: | 2012-09-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor.
J.Med.Chem., 55, 2012
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4G1D
 | | Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor | | Descriptor: | 3-(5'-{[3,4-bis(hydroxymethyl)benzyl]oxy}-2'-methyl-2-propylbiphenyl-4-yl)pentan-3-ol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | | Authors: | Ciesielski, F, Sato, Y, Moras, D, Rochel, N. | | Deposit date: | 2012-07-10 | | Release date: | 2012-09-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin d nuclear receptor.
J.Med.Chem., 55, 2012
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4FHH
 | | Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition | | Descriptor: | N-hydroxy-2-{4-[3-(4-{[(2S)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide, Nuclear receptor coactivator 2, Vitamin D3 receptor A | | Authors: | Fischer, J, Wang, T.T, Kaldre, D, Rochel, N, Moras, D, White, J.H, Gleason, J.L. | | Deposit date: | 2012-06-06 | | Release date: | 2012-09-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition.
Chem.Biol., 19, 2012
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4FHI
 | | Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition | | Descriptor: | N-hydroxy-2-{4-[3-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide, SRC-1, Vitamin Nuclear Receptor | | Authors: | Fischer, J, Wang, T.T, Kaldre, D, Rochel, N, Moras, D, White, J.H, Gleason, J.L. | | Deposit date: | 2012-06-06 | | Release date: | 2012-09-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition.
Chem.Biol., 19, 2012
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