2MG6
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![BU of 2mg6 by Molmil](/molmil-images/mine/2mg6) | Non-reducible analogues of alpha-conotoxin Vc1.1: [3,16]-trans dicarba Vc1.1 | Descriptor: | Alpha-conotoxin Vc1A | Authors: | Robinson, S.D, Macraild, C.A, Van Lierop, B.J, Robinson, A.J, Norton, R.S. | Deposit date: | 2013-10-28 | Release date: | 2013-12-18 | Method: | SOLUTION NMR | Cite: | Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. Acs Chem.Biol., 8, 2013
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2MFY
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![BU of 2mfy by Molmil](/molmil-images/mine/2mfy) | Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-trans dicarba Vc1.1 | Descriptor: | Alpha-conotoxin Vc1A | Authors: | Robinson, S.D, Macraild, C.A, Van Lierop, B.J, Robinson, A.J, Norton, R.S. | Deposit date: | 2013-10-24 | Release date: | 2013-12-18 | Method: | SOLUTION NMR | Cite: | Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. Acs Chem.Biol., 8, 2013
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2MFX
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![BU of 2mfx by Molmil](/molmil-images/mine/2mfx) | Non-reducible analogues of alpha-conotoxin Vc1.1: [2,8]-cis dicarba Vc1.1 | Descriptor: | Alpha-conotoxin Vc1A | Authors: | Robinson, S.D, Macraild, C.A, Van Lierop, B.J, Robinson, A.J, Norton, R.S. | Deposit date: | 2013-10-24 | Release date: | 2013-12-18 | Method: | SOLUTION NMR | Cite: | Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. Acs Chem.Biol., 8, 2013
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2N24
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![BU of 2n24 by Molmil](/molmil-images/mine/2n24) | |
7KNN
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![BU of 7knn by Molmil](/molmil-images/mine/7knn) | |
7R6P
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![BU of 7r6p by Molmil](/molmil-images/mine/7r6p) | |
2MTO
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![BU of 2mto by Molmil](/molmil-images/mine/2mto) | Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA | Descriptor: | Alpha-conotoxin RgIA | Authors: | Chhabra, S, Robinson, S, Norton, R. | Deposit date: | 2014-08-26 | Release date: | 2014-11-26 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets. J.Med.Chem., 57, 2014
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2MTU
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![BU of 2mtu by Molmil](/molmil-images/mine/2mtu) | Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-trans dicarba RgIA | Descriptor: | Dicarba Analogues of alpha-Conotoxin RgIA | Authors: | Chhabra, S, Robinson, S.D, Norton, R.S. | Deposit date: | 2014-09-01 | Release date: | 2014-11-26 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets. J.Med.Chem., 57, 2014
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2MTT
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![BU of 2mtt by Molmil](/molmil-images/mine/2mtt) | Non-reducible analogues of alpha-conotoxin RgIA: [3,12]-cis dicarba RgIA | Descriptor: | Dicarba Analogues of alpha-Conotoxin RgIA | Authors: | Chhabra, S, Robinson, S.D, Norton, R.S. | Deposit date: | 2014-08-31 | Release date: | 2014-11-26 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Dicarba Analogues of alpha-Conotoxin RgIA. Structure, Stability, and Activity at Potential Pain Targets. J.Med.Chem., 57, 2014
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5KKM
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![BU of 5kkm by Molmil](/molmil-images/mine/5kkm) | Con-Vc11-22 | Descriptor: | O2_contryphan_Vc1 prepropeptide | Authors: | Chittoor, B, Krishnarjuna, B, MacRaild, C.A, Robinson, S.D. | Deposit date: | 2016-06-22 | Release date: | 2017-05-31 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The Single Disulfide-Directed beta-Hairpin Fold. Dynamics, Stability, and Engineering. Biochemistry, 56, 2017
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5F4N
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![BU of 5f4n by Molmil](/molmil-images/mine/5f4n) | Multi-parameter lead optimization to give an oral CHK1 inhibitor clinical candidate: (R)-5-((4-((morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737) | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Serine/threonine-protein kinase Chk1, ... | Authors: | Collins, I, Garrett, M.D, van Montfort, R, Osborne, J.D, Matthews, T.P, McHardy, T, Proisy, N, Cheung, K.J, Lainchbury, M, Brown, N, Walton, M.I, Eve, P.D, Boxall, K.J, Hayes, A, Henley, A.T, Valenti, M.R, De Haven Brandon, A.K, Box, G, Westwood, I.M, Jamin, Y, Robinson, S.P, Leonard, P, Reader, J.C, Aherne, G.W, Raynaud, F.I, Eccles, S.A. | Deposit date: | 2015-12-03 | Release date: | 2016-05-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). J.Med.Chem., 59, 2016
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1E3B
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![BU of 1e3b by Molmil](/molmil-images/mine/1e3b) | CYCLOPHILIN 3 FROM C.ELEGANS COMPLEXED WITH AUP(ET)3 | Descriptor: | CYCLOPHILIN 3, GOLD ION, TRIETHYLPHOSPHANE | Authors: | Zou, J, Taylor, P, Dornan, J, Robinson, S.P, Walkinshaw, M.D, Sadler, P.J. | Deposit date: | 2000-06-08 | Release date: | 2000-10-22 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | First Crystal Structure of a Medicinally Relevant Gold Protein Complex:Unexpected Binding of [Au(Pet (3))](+) to Histidine Angew.Chem.Int.Ed.Engl., 39, 2000
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