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PDB: 44 件
1JXQ
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Structure of cleaved, CARD domain deleted Caspase-9
分子名称: Caspase-9, benzoxycarbonyl-Val-Ala-Asp-fluoromethyl ketone Inhibitor
著者Renatus, M, Stennicke, H.R, Scott, F.L, Liddington, R.C, Salvesen, G.S.
登録日2001-09-08
公開日2001-12-12
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Dimer formation drives the activation of the cell death protease caspase 9.
Proc.Natl.Acad.Sci.USA, 98, 2001
2FOM
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BU of 2fom by Molmil
Dengue Virus NS2B/NS3 Protease
分子名称: CHLORIDE ION, GLYCEROL, polyprotein
著者Schiering, N, Kroemer, M, Renatus, M, Erbel, P, D'Arcy, A.
登録日2006-01-13
公開日2006-03-07
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat.Struct.Mol.Biol., 13, 2006
2WDP
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Crystal Structure of Ligand Free Human Caspase-6
分子名称: CASPASE-6, PHOSPHATE ION
著者Baumgartner, R, Briand, C, Meder, G, Morse, R, Renatus, M.
登録日2009-03-25
公開日2009-10-27
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The Crystal Structure of Caspase-6, a Selective Effector of Axonal Degeneration.
Biochem.J., 423, 2009
1BDA
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CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE)
分子名称: N-{[5-(dimethylamino)naphthalen-2-yl]sulfonyl}-L-alpha-glutamyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl) butyl]glycinamide, SINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR
著者Bode, W, Renatus, M, Engh, R.A.
登録日1998-05-07
公開日1999-05-11
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.
EMBO J., 16, 1997
1XB0
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Structure of the BIR domain of IAP-like protein 2
分子名称: Baculoviral IAP repeat-containing protein 8, Diablo homolog, mitochondrial, ...
著者Shin, H, Renatus, M, Eckelman, B.P, Nunes, V.A, Sampaio, C.A.M, Salvesen, G.S.
登録日2004-08-27
公開日2004-11-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition
Biochem.J., 385, 2005
1XB1
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The Structure of the BIR domain of IAP-like protein 2
分子名称: Baculoviral IAP repeat-containing protein 8, Diablo homolog, mitochondrial, ...
著者Shin, H, Renatus, M, Eckelman, B.P, Nunes, V.A, Sampaio, C.A.M, Salvesen, G.S.
登録日2004-08-27
公開日2004-11-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition
Biochem.J., 385, 2005
8OGB
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 8
分子名称: 1,2-ETHANEDIOL, DDB1- and CUL4-associated factor 1, DIMETHYL SULFOXIDE, ...
著者Schroeder, M, Vulpetti, A, Renatus, M.
登録日2023-03-19
公開日2023-06-14
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
Acs Med.Chem.Lett., 14, 2023
8OG8
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 3
分子名称: 1,2-ETHANEDIOL, 5-(2-methyl-1-phenyl-propan-2-yl)imidazo[2,1-a]isoquinoline, ACETATE ION, ...
著者Schroeder, M, Vulpetti, A, Renatus, M.
登録日2023-03-19
公開日2023-06-14
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
Acs Med.Chem.Lett., 14, 2023
8OG7
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 2
分子名称: (4~{R})-4-[3-(4-chloranylphenoxy)phenyl]pyrrolidin-2-imine, 1,2-ETHANEDIOL, ACETATE ION, ...
著者Schroeder, M, Vulpetti, A, Renatus, M.
登録日2023-03-19
公開日2023-06-14
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
Acs Med.Chem.Lett., 14, 2023
8OG5
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 1
分子名称: 1,2-ETHANEDIOL, 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, ACETATE ION, ...
著者Schroeder, M, Vulpetti, A, Renatus, M.
登録日2023-03-19
公開日2023-06-14
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
Acs Med.Chem.Lett., 14, 2023
8OGA
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 6
分子名称: 1,2-ETHANEDIOL, 5-[1-(4-methoxyphenyl)cyclopropyl]-8-(4-methylpiperazin-1-yl)-2,3-dihydroimidazo[2,1-a]isoquinoline, DDB1- and CUL4-associated factor 1, ...
著者Schroeder, M, Vulpetti, A, Renatus, M.
登録日2023-03-19
公開日2023-06-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
Acs Med.Chem.Lett., 14, 2023
8OG6
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 1
分子名称: 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, ACETATE ION, DDB1- and CUL4-associated factor 1
著者Schroeder, M, Vulpetti, A, Renatus, M.
登録日2023-03-19
公開日2023-06-14
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.245 Å)
主引用文献Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
Acs Med.Chem.Lett., 14, 2023
8OG9
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 4
分子名称: 5-[1-(4-chlorophenyl)cyclopropyl]imidazo[2,1-a]isoquinoline, DDB1- and CUL4-associated factor 1
著者Schroeder, M, Vulpetti, A, Renatus, M.
登録日2023-03-19
公開日2023-06-14
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.945 Å)
主引用文献Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
Acs Med.Chem.Lett., 14, 2023
8OGC
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 11
分子名称: 1,2-ETHANEDIOL, 1-[4-[4-(2-azanylethylamino)-2-[1-(4-chlorophenyl)cyclopentyl]quinazolin-7-yl]piperazin-1-yl]ethanone, ACETATE ION, ...
著者Schroeder, M, Vulpetti, A, Renatus, M.
登録日2023-03-19
公開日2023-06-14
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field.
Acs Med.Chem.Lett., 14, 2023
8OO5
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 13
分子名称: 1,2-ETHANEDIOL, 1-[4-[4-(2-azanylethylamino)-2-[1-(4-chlorophenyl)cyclohexyl]quinazolin-7-yl]piperazin-1-yl]ethanone, DDB1- and CUL4-associated factor 1
著者Schroeder, M, Renatus, M.
登録日2023-04-04
公開日2023-05-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings
Biorxiv, 2023
8OOD
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Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 15
分子名称: 1,2-ETHANEDIOL, ACETATE ION, DDB1- and CUL4-associated factor 1, ...
著者Schroeder, M, Renatus, M.
登録日2023-04-05
公開日2023-05-24
実験手法X-RAY DIFFRACTION (1.497 Å)
主引用文献Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings
Biorxiv, 2023
1J7N
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Anthrax Toxin Lethal factor
分子名称: Lethal Factor precursor, SULFATE ION, ZINC ION
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-05-17
公開日2001-11-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
1I3O
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CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3
分子名称: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, CASPASE 3, ZINC ION
著者Riedl, S.J, Renatus, M, Schwarzenbacher, R, Zhou, Q, Sun, C, Fesik, S.W, Liddington, R.C, Salvesen, G.S.
登録日2001-02-15
公開日2001-03-21
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for the inhibition of caspase-3 by XIAP.
Cell(Cambridge,Mass.), 104, 2001
1JKY
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Crystal Structure of the Anthrax Lethal Factor (LF): Wild-type LF Complexed with the N-terminal Sequence of MAPKK2
分子名称: Lethal Factor, mitogen-activated protein kinase kinase 2
著者Pannifer, A.D, Wong, T.Y, Schwarzenbacher, R, Renatus, M, Petosa, C, Collier, R.J, Bienkowska, J, Lacy, D.B, Park, S, Leppla, S.H, Hanna, P, Liddington, R.C.
登録日2001-07-13
公開日2001-11-07
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Crystal structure of the anthrax lethal factor.
Nature, 414, 2001
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