8OGB

Crystal structure of human DCAF1 WD40 repeats (Q1250L) in complex with compound 8

Summary for 8OGB

Entry DOI	10.2210/pdb8ogb/pdb
Related	8OG5 8OG6 8OG7 8OG8 8OG9 8OGA
Descriptor	DDB1- and CUL4-associated factor 1, 1,2-ETHANEDIOL, ~{N}'-[2-[1-(4-methoxyphenyl)cyclopropyl]-7-(4-methylpiperazin-1-yl)quinazolin-4-yl]ethane-1,2-diamine, ... (5 entities in total)
Functional Keywords	dcaf1, e3 ligase, compound, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42415.72
Authors	Schroeder, M.,Vulpetti, A.,Renatus, M. (deposition date: 2023-03-19, release date: 2023-06-14, Last modification date: 2023-08-02)
Primary citation	Vulpetti, A.,Holzer, P.,Schmiedeberg, N.,Imbach-Weese, P.,Pissot-Soldermann, C.,Hollingworth, G.J.,Radimerski, T.,Thoma, C.R.,Stachyra, T.M.,Wojtynek, M.,Maschlej, M.,Chau, S.,Schuffenhauer, A.,Fernandez, C.,Schroder, M.,Renatus, M. Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field. Acs Med.Chem.Lett., 14:949-954, 2023 Cited by PubMed: 37465299 DOI: 10.1021/acsmedchemlett.3c00104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation