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PDB: 11 件
3CF6
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Structure of Epac2 in complex with cyclic-AMP and Rap
分子名称: 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, Rap guanine nucleotide exchange factor (GEF) 4, Ras-related protein Rap-1b, ...
著者Rehmann, H, Arias-Palomo, E, Hadders, M.A, Schwede, F, Llorca, O, Bos, J.L.
登録日2008-03-02
公開日2008-07-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
Nature, 455, 2008
2BYV
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BU of 2byv by Molmil
Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state
分子名称: RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4
著者Rehmann, H, Wittinghofer, A, Bos, J.L.
登録日2005-08-08
公開日2006-02-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the Cyclic-AMP Responsive Exchange Factor Epac2 in its Auto-Inhibited State
Nature, 439, 2006
1O7F
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BU of 1o7f by Molmil
CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2
分子名称: CAMP-DEPENDENT RAP1 GUANINE-NUCLEOTIDE EXCHANGE FACTOR
著者Rehmann, H, Prakash, B, Wolf, E, Rueppel, A, De Rooij, J, Bos, J.L, Wittinghofer, A.
登録日2002-11-04
公開日2002-11-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure and Regulation of the Camp-Binding Domains of Epac2
Nat.Struct.Biol., 10, 2002
4JGW
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The conformation of a docking site for SH3 domains is pre-selected in the Guanine Nucleotide Exchange Factor Rlf
分子名称: Ral guanine nucleotide dissociation stimulator-like 2
著者Rehmann, H, Popovic, M, Jakobi, A.J.
登録日2013-03-04
公開日2013-09-11
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.
J.Struct.Biol., 183, 2013
4MH0
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BU of 4mh0 by Molmil
Selective activation of Epac1 and Epac2
分子名称: (2S,4aR,6R,7R,7aS)-6-{6-amino-8-[(4-fluorobenzyl)sulfanyl]-9H-purin-9-yl}-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
著者Rehmann, H.
登録日2013-08-29
公開日2014-09-03
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Selective activation of Epac1 and Epac2
To be Published
4MGI
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BU of 4mgi by Molmil
Selective activation of Epac1 and Epac2
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
著者Rehmann, H.
登録日2013-08-28
公開日2014-09-03
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Selective activation of Epac1 and Epac2
To be Published
4MGY
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Selective activation of Epac1 and Epac2
分子名称: (2S,4aR,6R,7R,7aR)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-methoxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
著者Rehmann, H.
登録日2013-08-29
公開日2014-09-03
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Selective activation of Epac1 and Epac2
To be Published
4MGK
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BU of 4mgk by Molmil
Selective activation of Epac1 and Epac2
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
著者Rehmann, H.
登録日2013-08-28
公開日2014-09-03
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Selective activation of Epac1 and Epac2
To be Published
4MGZ
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Selective activation of Epac1 and Epac2
分子名称: (2S,4aR,6R,7R,7aS)-6-[6-amino-8-(benzylsulfanyl)-9H-purin-9-yl]-2-sulfanyltetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol 2-oxide, Rap guanine nucleotide exchange factor 4, Ras-related protein Rap-1b, ...
著者Rehmann, H.
登録日2013-08-29
公開日2014-09-03
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Selective activation of Epac1 and Epac2
To be Published
5CM9
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BU of 5cm9 by Molmil
Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral
分子名称: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a
著者Popovic, M, Schouten, A, Rehmann, H.
登録日2015-07-16
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity.
J.Struct.Biol., 193, 2016
5CM8
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BU of 5cm8 by Molmil
Structural Basis for the Selectivity of Guanine Nucleotide Exchange Factors for the small G-protein Ral
分子名称: Ral guanine nucleotide dissociation stimulator-like 2, Ras-related protein Ral-a
著者Popovic, M, Schouten, A, Rehmann, H.
登録日2015-07-16
公開日2016-01-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity.
J.Struct.Biol., 193, 2016

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件を2024-10-30に公開中

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