8ENL
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![BU of 8enl by Molmil](/molmil-images/mine/8enl) | CryoEM structure of the high pH turnover-inactivated nitrogenase MoFe-protein | Descriptor: | CHAPSO, FE (III) ION, FE(8)-S(7) CLUSTER, ... | Authors: | Warmack, R.A, Maggiolo, A.O, Rees, D.C. | Deposit date: | 2022-09-30 | Release date: | 2023-03-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.37 Å) | Cite: | Structural consequences of turnover-induced homocitrate loss in nitrogenase. Nat Commun, 14, 2023
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8ENN
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![BU of 8enn by Molmil](/molmil-images/mine/8enn) | Homocitrate-deficient nitrogenase MoFe-protein from Azotobacter vinelandii nifV knockout | Descriptor: | CHAPSO, CITRIC ACID, FE (III) ION, ... | Authors: | Warmack, R.A, Maggiolo, A.O, Rees, D.C. | Deposit date: | 2022-09-30 | Release date: | 2023-03-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Structural consequences of turnover-induced homocitrate loss in nitrogenase. Nat Commun, 14, 2023
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8ENM
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![BU of 8enm by Molmil](/molmil-images/mine/8enm) | CryoEM structure of the high pH nitrogenase MoFe-protein under non-turnover conditions | Descriptor: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, FE (III) ION, FE(8)-S(7) CLUSTER, ... | Authors: | Warmack, R.A, Maggiolo, A.O, Rees, D.C. | Deposit date: | 2022-09-30 | Release date: | 2023-03-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.14 Å) | Cite: | Structural consequences of turnover-induced homocitrate loss in nitrogenase. Nat Commun, 14, 2023
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8ENO
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![BU of 8eno by Molmil](/molmil-images/mine/8eno) | Homocitrate-deficient nitrogenase MoFe-protein from A. vinelandii nifV knockout in complex with NafT | Descriptor: | CHAPSO, CITRIC ACID, FE (III) ION, ... | Authors: | Warmack, R.A, Maggiolo, A.O, Rees, D.C. | Deposit date: | 2022-09-30 | Release date: | 2023-03-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Structural consequences of turnover-induced homocitrate loss in nitrogenase. Nat Commun, 14, 2023
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6N4L
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![BU of 6n4l by Molmil](/molmil-images/mine/6n4l) | Dithionite-reduced ADP-bound form of the nitrogenase Fe-protein from A. vinelandii | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | Authors: | Wenke, B.B, Spatzal, T, Rees, D.C. | Deposit date: | 2018-11-19 | Release date: | 2019-02-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | Site-Specific Oxidation State Assignments of the Iron Atoms in the [4Fe:4S]2+/1+/0States of the Nitrogenase Fe-Protein. Angew. Chem. Int. Ed. Engl., 58, 2019
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6N4M
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![BU of 6n4m by Molmil](/molmil-images/mine/6n4m) | IDS-oxidized ADP-bound form of the nitrogenase Fe-protein from A. vinelandii | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | Authors: | Wenke, B.B, Spatzal, T, Rees, D.C. | Deposit date: | 2018-11-19 | Release date: | 2019-02-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Site-Specific Oxidation State Assignments of the Iron Atoms in the [4Fe:4S]2+/1+/0States of the Nitrogenase Fe-Protein. Angew. Chem. Int. Ed. Engl., 58, 2019
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6N4J
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![BU of 6n4j by Molmil](/molmil-images/mine/6n4j) | |
6N4K
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![BU of 6n4k by Molmil](/molmil-images/mine/6n4k) | |
8TC3
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![BU of 8tc3 by Molmil](/molmil-images/mine/8tc3) | |
4PKE
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![BU of 4pke by Molmil](/molmil-images/mine/4pke) | The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold | Descriptor: | PLATINUM (II) ION, Protein C10C5.1, isoform i | Authors: | Kamajaya, A, Kaiser, J, Lee, J, Reid, M, Rees, D.C. | Deposit date: | 2014-05-14 | Release date: | 2014-10-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct beta Sandwich Fold. Structure, 22, 2014
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4PKX
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![BU of 4pkx by Molmil](/molmil-images/mine/4pkx) | The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold | Descriptor: | Protein C10C5.1, isoform i | Authors: | Kamajaya, A, Kaiser, J, Lee, J, Reid, M, Rees, D.C. | Deposit date: | 2014-05-15 | Release date: | 2014-10-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct beta Sandwich Fold. Structure, 22, 2014
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3TG0
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![BU of 3tg0 by Molmil](/molmil-images/mine/3tg0) | E. coli alkaline phosphatase with bound inorganic phosphate | Descriptor: | Alkaline phosphatase, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Bobyr, E, Lassila, J.K, Wiersma-Koch, H.I, Fenn, T.D, Lee, J.J, Nikolic-Hughes, I, Hodgson, K.O, Rees, D.C, Hedman, B, Herschlag, D. | Deposit date: | 2011-08-16 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography. J.Mol.Biol., 415, 2012
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4TKV
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![BU of 4tkv by Molmil](/molmil-images/mine/4tkv) | CO-bound Nitrogenase MoFe-protein from A. vinelandii | Descriptor: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, CARBON MONOXIDE, FE (II) ION, ... | Authors: | Spatzal, T, Perez, K, Einsle, O, Howard, J.B, Rees, D.C. | Deposit date: | 2014-05-28 | Release date: | 2014-10-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase. Science, 345, 2014
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4TKU
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![BU of 4tku by Molmil](/molmil-images/mine/4tku) | Reactivated Nitrogenase MoFe-protein from A. vinelandii | Descriptor: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, CHLORIDE ION, FE (II) ION, ... | Authors: | Spatzal, T, Perez, K, Einsle, O, Howard, J.B, Rees, D.C. | Deposit date: | 2014-05-27 | Release date: | 2014-10-01 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase. Science, 345, 2014
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3TUI
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![BU of 3tui by Molmil](/molmil-images/mine/3tui) | |
3TUJ
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![BU of 3tuj by Molmil](/molmil-images/mine/3tuj) | |
3TUZ
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![BU of 3tuz by Molmil](/molmil-images/mine/3tuz) | Inward facing conformations of the MetNI methionine ABC transporter: CY5 SeMet soak crystal form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, D-methionine transport system permease protein metI, Methionine import ATP-binding protein MetN, ... | Authors: | Johnson, E, Nguyen, P, Rees, D.C. | Deposit date: | 2011-09-19 | Release date: | 2011-11-30 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Inward facing conformations of the MetNI methionine ABC transporter: Implications for the mechanism of transinhibition. Protein Sci., 21, 2012
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4D2W
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![BU of 4d2w by Molmil](/molmil-images/mine/4d2w) | Structure of MELK in complex with inhibitors | Descriptor: | 4-bromo-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide, MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | Authors: | Johnson, C.N, Berdini, V, Beke, L, Bonnet, P, Brehmer, D, Coyle, J.E, Day, P.J, Frederickson, M, Freyne, E.J.E, Gilissen, R.A.H.J, Hamlett, C.C.F, Howard, S, Meerpoel, L, McMenamin, R, Patel, S, Rees, D.C, Sharff, A, Sommen, F, Wu, T, Linders, J.T.M. | Deposit date: | 2014-05-13 | Release date: | 2014-10-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase Acs Med.Chem.Lett., 6, 2015
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4D2V
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![BU of 4d2v by Molmil](/molmil-images/mine/4d2v) | Structure of MELK in complex with inhibitors | Descriptor: | 7-{[2-methoxy-4-(1H-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1H-3-benzazepinium, MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | Authors: | Johnson, C.N, Berdini, V, Beke, L, Bonnet, P, Brehmer, D, Coyle, J.E, Day, P.J, Frederickson, M, Freyne, E.J.E, Gilissen, R.A.H.J, Hamlett, C.C.F, Howard, S, Meerpoel, L, McMenamin, R, Patel, S, Rees, D.C, Sharff, A, Sommen, F, Wu, T, Linders, J.T.M. | Deposit date: | 2014-05-13 | Release date: | 2014-10-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase Acs Med.Chem.Lett., 6, 2015
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4D2T
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![BU of 4d2t by Molmil](/molmil-images/mine/4d2t) | Structure of MELK in complex with inhibitors | Descriptor: | 3-[2-(phenylcarbamoyl)-5-(1H-pyrazol-4-yl)phenoxy]propan-1-aminium, MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | Authors: | Johnson, C.N, Berdini, V, Beke, L, Bonnet, P, Brehmer, D, Coyle, J.E, Day, P.J, Frederickson, M, Freyne, E.J.E, Gilissen, R.A.H.J, Hamlett, C.C.F, Howard, S, Meerpoel, L, McMenamin, R, Patel, S, Rees, D.C, Sharff, A, Sommen, F, Wu, T, Linders, J.T.M. | Deposit date: | 2014-05-13 | Release date: | 2014-10-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase Acs Med.Chem.Lett., 6, 2015
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4D2P
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![BU of 4d2p by Molmil](/molmil-images/mine/4d2p) | Structure of MELK in complex with inhibitors | Descriptor: | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium, MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | Authors: | Johnson, C.N, Berdini, V, Beke, L, Bonnet, P, Brehmer, D, Coyle, J.E, Day, P.J, Frederickson, M, Freyne, E.J.E, Gilissen, R.A.H.J, Hamlett, C.C.F, Howard, S, Meerpoel, L, McMenamin, R, Patel, S, Rees, D.C, Sharff, A, Sommen, F, Wu, T, Linders, J.T.M. | Deposit date: | 2014-05-12 | Release date: | 2014-10-08 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase Acs Med.Chem.Lett., 6, 2015
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6DZX
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![BU of 6dzx by Molmil](/molmil-images/mine/6dzx) | Crystal structure of the N. meningitides methionine-binding protein in its D-methionine bound conformation. | Descriptor: | D-METHIONINE, Lipoprotein | Authors: | Nguyen, P.T, Lai, J.Y, Kaiser, J.T, Rees, D.C. | Deposit date: | 2018-07-05 | Release date: | 2019-07-10 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.678 Å) | Cite: | Structures of the Neisseria meningitides methionine-binding protein MetQ in substrate-free form and bound to l- and d-methionine isomers. Protein Sci., 28, 2019
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3PDI
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![BU of 3pdi by Molmil](/molmil-images/mine/3pdi) | Precursor bound NifEN | Descriptor: | IRON/SULFUR CLUSTER, L-Cluster (Fe8S9), Nitrogenase MoFe cofactor biosynthesis protein NifE, ... | Authors: | Kaiser, J.T, Hu, Y, Wiig, J.A, Rees, D.C, Ribbe, M.W. | Deposit date: | 2010-10-22 | Release date: | 2011-01-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of Precursor-Bound NifEN: A Nitrogenase FeMo Cofactor Maturase/Insertase. Science, 331, 2011
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3PSA
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![BU of 3psa by Molmil](/molmil-images/mine/3psa) | Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein MolA (MolA bound to tungstate) | Descriptor: | TUNGSTATE(VI)ION, protein HI_1472 | Authors: | Tirado-Lee, L, Lee, A, Rees, D.C, Pinkett, H.W. | Deposit date: | 2010-12-01 | Release date: | 2011-11-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Classification of a Haemophilus influenzae ABC Transporter HI1470/71 through Its Cognate Molybdate Periplasmic Binding Protein, MolA. Structure, 19, 2011
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3PSH
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![BU of 3psh by Molmil](/molmil-images/mine/3psh) | Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein MolA (MolA bound to Molybdate) | Descriptor: | MOLYBDATE ION, protein HI_1472 | Authors: | Tirado-Lee, L, Lee, A, Rees, D.C, Pinkett, H.W. | Deposit date: | 2010-12-01 | Release date: | 2011-11-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Classification of a Haemophilus influenzae ABC Transporter HI1470/71 through Its Cognate Molybdate Periplasmic Binding Protein, MolA. Structure, 19, 2011
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