4D2P
Structure of MELK in complex with inhibitors
Summary for 4D2P
Entry DOI | 10.2210/pdb4d2p/pdb |
Related | 4D2T 4D2V 4D2W |
Descriptor | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium (3 entities in total) |
Functional Keywords | transferase, fragment sterbased drug design, kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane ; Peripheral membrane protein : Q14680 |
Total number of polymer chains | 4 |
Total formula weight | 165066.91 |
Authors | Johnson, C.N.,Berdini, V.,Beke, L.,Bonnet, P.,Brehmer, D.,Coyle, J.E.,Day, P.J.,Frederickson, M.,Freyne, E.J.E.,Gilissen, R.A.H.J.,Hamlett, C.C.F.,Howard, S.,Meerpoel, L.,McMenamin, R.,Patel, S.,Rees, D.C.,Sharff, A.,Sommen, F.,Wu, T.,Linders, J.T.M. (deposition date: 2014-05-12, release date: 2014-10-08, Last modification date: 2024-05-08) |
Primary citation | Johnson, C.N.,Berdini, V.,Beke, L.,Bonnet, P.,Brehmer, D.,Coyle, J.E.,Day, P.J.,Frederickson, M.,Freyne, E.J.E.,Gilissen, R.A.H.J.,Hamlett, C.C.F.,Howard, S.,Meerpoel, L.,Mcmenamin, R.,Patel, S.,Rees, D.C.,Sharff, A.,Sommen, F.,Wu, T.,Linders, J.T.M. Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase Acs Med.Chem.Lett., 6:25-, 2015 Cited by PubMed: 25589925DOI: 10.1021/ML5001245 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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