5ENV
 
 | | YEAST ALCOHOL DEHYDROGENASE WITH BOUND COENZYME | | Descriptor: | Alcohol dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRIFLUOROETHANOL, ... | | Authors: | Plapp, B.V, Charlier Jr, H.A, Ramaswamy, S. | | Deposit date: | 2015-11-09 | | Release date: | 2015-11-25 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol.
Arch.Biochem.Biophys., 591, 2015
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1JU9
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4JQW
 | | Crystal Structure of a Complex of NOD1 CARD and Ubiquitin | | Descriptor: | Nucleotide-binding oligomerization domain-containing protein 1, PHOSPHATE ION, Polyubiquitin-C | | Authors: | Ver Heul, A.M, Gakhar, L, Piper, R.C, Ramaswamy, S. | | Deposit date: | 2013-03-20 | | Release date: | 2014-03-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of a complex of NOD1 CARD and ubiquitin
Plos One, 9, 2014
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1J90
 | | Crystal Structure of Drosophila Deoxyribonucleoside Kinase | | Descriptor: | 2'-DEOXYCYTIDINE, Deoxyribonucleoside kinase, SULFATE ION | | Authors: | Johansson, K, Ramaswamy, S, Ljungkrantz, C, Knecht, W, Piskur, J, Munch-Petersen, B, Eriksson, S, Eklund, H. | | Deposit date: | 2001-05-23 | | Release date: | 2001-11-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Structural basis for substrate specificities of cellular deoxyribonucleoside kinases.
Nat.Struct.Biol., 8, 2001
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2OCP
 | | Crystal Structure of Human Deoxyguanosine Kinase | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Deoxyguanosine kinase | | Authors: | Johansson, K, Ramaswamy, S, Ljungkrantz, C, Knecht, W, Piskur, J, Munch-Petersen, B, Eriksson, S, Eklund, H. | | Deposit date: | 2006-12-21 | | Release date: | 2007-01-16 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Basis for Substrate Specificities of Cellular Deoxyribonucleoside Kinases.
Nat.Struct.Biol., 8, 2001
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3GPM
 | | Structure of the trimeric form of the E113G PCNA mutant protein | | Descriptor: | Proliferating cell nuclear antigen | | Authors: | Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. | | Deposit date: | 2009-03-23 | | Release date: | 2009-06-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions.
Acta Crystallogr.,Sect.D, 65, 2009
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1GUZ
 | | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases | | Descriptor: | MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H. | | Deposit date: | 2002-02-04 | | Release date: | 2002-02-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
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1GV0
 | | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases | | Descriptor: | MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H. | | Deposit date: | 2002-02-04 | | Release date: | 2002-02-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
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1GUY
 | | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases | | Descriptor: | CADMIUM ION, MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H. | | Deposit date: | 2002-02-04 | | Release date: | 2002-02-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
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1GV1
 | | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases | | Descriptor: | MALATE DEHYDROGENASE | | Authors: | Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H. | | Deposit date: | 2002-02-04 | | Release date: | 2002-02-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
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3GPN
 | | Structure of the non-trimeric form of the E113G PCNA mutant protein | | Descriptor: | Proliferating cell nuclear antigen | | Authors: | Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. | | Deposit date: | 2009-03-23 | | Release date: | 2009-06-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions.
Acta Crystallogr.,Sect.D, 65, 2009
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3JWQ
 | | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with sildenafil | | Descriptor: | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, MAGNESIUM ION, ZINC ION, ... | | Authors: | Barren, B, Gakhar, L, Muradov, H, Boyd, K.K, Ramaswamy, S, Artemyev, N.O. | | Deposit date: | 2009-09-18 | | Release date: | 2009-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.87 Å) | | Cite: | Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
Embo J., 28, 2009
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3JWR
 | | Crystal structure of chimeric PDE5/PDE6 catalytic domain complexed with 3-isobutyl-1-methylxanthine (IBMX) and PDE6 gamma-subunit inhibitory peptide 70-87. | | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ... | | Authors: | Barren, B, Gakhar, L, Muradov, H, Boyd, K.K, Ramaswamy, S, Artemyev, N.O. | | Deposit date: | 2009-09-18 | | Release date: | 2009-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.994 Å) | | Cite: | Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
Embo J., 28, 2009
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5VJ5
 | | Horse Liver Alcohol Dehydrogenase Complexed with 1,10-Phenanthroline | | Descriptor: | 1,10-PHENANTHROLINE, Alcohol dehydrogenase E chain, ZINC ION | | Authors: | Plapp, B.V, Baskar Raj, S, Ramaswamy, S. | | Deposit date: | 2017-04-18 | | Release date: | 2017-05-03 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis.
Biochemistry, 56, 2017
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7JQA
 | | EQADH-NADH-4-BROMOBENZYL ALCOHOL, P21 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Alcohol dehydrogenase E chain, ... | | Authors: | Plapp, B.V, Ramaswamy, S. | | Deposit date: | 2020-08-10 | | Release date: | 2020-08-19 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Alternative binding modes in abortive NADH-alcohol complexes of horse liver alcohol dehydrogenase.
Arch.Biochem.Biophys., 701, 2021
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7K35
 | | EQADH-NADH-4-METHYLBENZYL ALCOHOL, p21 | | Descriptor: | (4-methylphenyl)methanol, (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | | Authors: | Plapp, B.V, Ramaswamy, S. | | Deposit date: | 2020-09-10 | | Release date: | 2020-09-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Alternative binding modes in abortive NADH-alcohol complexes of horse liver alcohol dehydrogenase.
Arch.Biochem.Biophys., 701, 2021
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4OJA
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5NVA
 | | Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site | | Descriptor: | N-acetyl-beta-neuraminic acid, Putative sodium:solute symporter, SODIUM ION | | Authors: | Wahlgren, W.Y, North, R.A, Dunevall, E, Goyal, P, Grabe, M, Dobson, R, Abramson, J, Ramaswamy, S, Friemann, R. | | Deposit date: | 2017-05-03 | | Release date: | 2018-04-04 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site.
Nat Commun, 9, 2018
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5NV9
 | | Substrate-bound outward-open state of a Na+-coupled sialic acid symporter reveals a novel Na+-site | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, N-acetyl-beta-neuraminic acid, PHOSPHATE ION, ... | | Authors: | Wahlgren, W.Y, North, R.A, Dunevall, E, Paz, A, Goyal, P, Bisignano, P, Grabe, M, Dobson, R, Abramson, J, Ramaswamy, S, Friemann, R. | | Deposit date: | 2017-05-03 | | Release date: | 2018-04-04 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site.
Nat Commun, 9, 2018
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7EUA
 | | X-ray structure of a P93A Monellin mutant | | Descriptor: | Monellin, SULFATE ION | | Authors: | Manjula, R, Bhatia, S, Jayant, B, Ramaswamy, S, Gosavi, S. | | Deposit date: | 2021-05-16 | | Release date: | 2021-08-11 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | X-ray structure of a P93A Monellin mutant
To Be Published
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7O2Y
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7MDH
 | | STRUCTURAL BASIS FOR LIGHT ACITVATION OF A CHLOROPLAST ENZYME. THE STRUCTURE OF SORGHUM NADP-MALATE DEHYDROGENASE IN ITS OXIDIZED FORM | | Descriptor: | PROTEIN (MALATE DEHYDROGENASE), ZINC ION | | Authors: | Johansson, K, Ramaswamy, S, Saarinen, M, Lemaire-Chamley, M, Issakidis-Bourguet, E, Miginiac-Maslow, M, Eklund, H. | | Deposit date: | 1999-02-16 | | Release date: | 1999-06-04 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for light activation of a chloroplast enzyme: the structure of sorghum NADP-malate dehydrogenase in its oxidized form.
Biochemistry, 38, 1999
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4DXH
 | | Horse liver alcohol dehydrogenase complexed with NAD+ and 2,2,2-trifluoroethanol | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Alcohol dehydrogenase E chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (ACIDIC FORM), ... | | Authors: | Plapp, B.V, Ramaswamy, S. | | Deposit date: | 2012-02-27 | | Release date: | 2012-04-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.12 Å) | | Cite: | Atomic-Resolution Structures of Horse Liver Alcohol Dehydrogenase with NAD(+) and Fluoroalcohols Define Strained Michaelis Complexes.
Biochemistry, 51, 2012
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6L4J
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7DA8
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