6WJL
| Crystal structure of Glypican-2 core protein in complex with D3 Fab | 分子名称: | D3 Fab Heavy chain, D3 Fab Light Chain, Glypican-2, ... | 著者 | Raman, S, Maris, J.M, Bosse, K.R, Julien, J.P. | 登録日 | 2020-04-14 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope. Cell Rep Med, 2, 2021
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6O3A
| Crystal structure of Frizzled 7 CRD in complex with F7.B Fab | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ... | 著者 | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | 登録日 | 2019-02-26 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6O3B
| Crystal structure of Frizzled 7 CRD in complex with F6 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab F6, Heavy chain, ... | 著者 | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | 登録日 | 2019-02-26 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6O39
| Crystal structure of Frizzled 5 CRD in complex with F2.I Fab | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | 登録日 | 2019-02-26 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7N0A
| Structure of Human Leukaemia Inhibitory Factor with Fab MSC1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Leukemia inhibitory factor, ... | 著者 | Raman, S, Bosch, A, Fransson, J, Julien, J.P. | 登録日 | 2021-05-25 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment. Clin.Cancer Res., 29, 2023
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4XKK
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4XCL
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4XC0
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4X9L
| N-terminal domain of Heat shock protein 90 from Oryza sativa | 分子名称: | Heat shock protein, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, TETRAETHYLENE GLYCOL | 著者 | Raman, S, Suguna, K. | 登録日 | 2014-12-11 | 公開日 | 2015-06-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Functional characterization of heat-shock protein 90 from Oryza sativa and crystal structure of its N-terminal domain. Acta Crystallogr.,Sect.F, 71, 2015
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4XCJ
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4XDM
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4XE2
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4XKA
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4XD8
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4XKO
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7K1A
| TtgR quadruple mutant (C137I I141W M167L F168Y) | 分子名称: | HTH-type transcriptional regulator TtgR, MAGNESIUM ION | 著者 | Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. | 登録日 | 2020-09-07 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
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7KD8
| TtgR C137I I141W M167L F168Y mutant in complex with resveratrol | 分子名称: | HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL | 著者 | Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. | 登録日 | 2020-10-08 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
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7K1C
| TtgR in complex with resveratrol | 分子名称: | HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL | 著者 | Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S. | 登録日 | 2020-09-07 | 公開日 | 2021-10-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Epistasis shapes the fitness landscape of an allosteric specificity switch. Nat Commun, 12, 2021
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8ILU
| Crystal structure of mouse Galectin-3 in complex with small molecule inhibitor | 分子名称: | (2R,3R,4R,5R,6S)-2-(hydroxymethyl)-6-[2-(2-methyl-1,3-benzothiazol-6-yl)-1,2,4-triazol-3-yl]-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-3, SODIUM ION, ... | 著者 | Kumar, A, Jinal, S, Raman, S, Ghosh, K. | 登録日 | 2023-03-04 | 公開日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Identification of Benzothiazole Derived Monosaccharides as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3 To Be Published
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2L15
| Solution Structure of Cold Shock Protein CspA Using Combined NMR and CS-Rosetta method | 分子名称: | Cold shock protein CspA | 著者 | Tang, Y, Schneider, W.M, Shen, Y, Raman, S, Inouye, M, Baker, D, Roth, M.J, Montelione, G.T. | 登録日 | 2010-07-22 | 公開日 | 2010-09-15 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Fully automated high-quality NMR structure determination of small (2)H-enriched proteins. J Struct Funct Genomics, 11, 2010
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7XFA
| Structure of human Galectin-3 CRD in complex with monosaccharide inhibitor | 分子名称: | (2~{S},3~{R},4~{R},5~{R},6~{R})-4-[4-[4-chloranyl-3,5-bis(fluoranyl)phenyl]-1,2,3-triazol-1-yl]-2-[2-[5-chloranyl-2-(trifluoromethyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]-6-(hydroxymethyl)oxane-3,5-diol, Galectin-3 | 著者 | Shukla, J, Raman, S, Ghosh, K. | 登録日 | 2022-04-01 | 公開日 | 2022-10-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (0.98 Å) | 主引用文献 | Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3. J.Med.Chem., 65, 2022
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