2J9F
 
 | | Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase E1b | | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, C2-1-HYDROXY-3-METHYL-PROPYL-THIAMIN DIPHOSPHATE, ... | | 著者 | Jun, L, Machius, M, Chuang, J.L, Wynn, R.M, Chuang, D.T. | | 登録日 | 2006-11-07 | | 公開日 | 2007-02-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | The Two Active Sites in Human Branched-Chain Alpha- Keto Acid Dehydrogenase Operate Independently without an Obligatory Alternating-Site Mechanism.
J.Biol.Chem., 282, 2007
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1C0T
 | | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326 | | 分子名称: | (R)-(+)9B-(3-METHYL)PHENYL-2,3-DIHYDROTHIAZOLO[2,3-A]ISOINDOL-5(9BH)-ONE, HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN) | | 著者 | Ren, J, Esnouf, R.M, Hopkins, A.L, Stuart, D.I, Stammers, D.K. | | 登録日 | 1999-07-19 | | 公開日 | 2000-07-19 | | 最終更新日 | 2014-11-12 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.Med.Chem., 42, 1999
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1XEE
 | | Solution structure of the Chemotaxis Inhibitory Protein of Staphylococcus aureus | | 分子名称: | chemotaxis-inhibiting protein CHIPS | | 著者 | Haas, P.J, de Haas, C.J, Poppelier, M.J, van Kessel, K.P, van Strijp, J.A, Dijkstra, K, Scheek, R.M, Fan, H, Kruijtzer, J.A, Liskamp, R.M, Kemmink, J. | | 登録日 | 2004-09-10 | | 公開日 | 2005-09-27 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of Staphylococcus aureus is related to a group of immune evasive molecules
J.Mol.Biol., 353, 2005
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1IDC
 | | ISOCITRATE DEHYDROGENASE FROM E.COLI (MUTANT K230M), STEADY-STATE INTERMEDIATE COMPLEX DETERMINED BY LAUE CRYSTALLOGRAPHY | | 分子名称: | 2-OXALOSUCCINIC ACID, ISOCITRATE DEHYDROGENASE, MAGNESIUM ION | | 著者 | Bolduc, J.M, Dyer, D.H, Scott, W.G, Singer, P, Sweet, R.M, Koshland Junior, D.E, Stoddard, B.L. | | 登録日 | 1995-01-18 | | 公開日 | 1996-03-08 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
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1IDF
 | | ISOCITRATE DEHYDROGENASE K230M MUTANT APO ENZYME | | 分子名称: | ISOCITRATE DEHYDROGENASE | | 著者 | Bolduc, J.M, Dyer, D.H, Scott, W.G, Singer, P, Sweet, R.M, Koshland Junior, D.E, Stoddard, B.L. | | 登録日 | 1995-01-18 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
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1IDE
 | | ISOCITRATE DEHYDROGENASE Y160F MUTANT STEADY-STATE INTERMEDIATE COMPLEX (LAUE DETERMINATION) | | 分子名称: | ISOCITRATE DEHYDROGENASE, ISOCITRIC ACID, MAGNESIUM ION, ... | | 著者 | Bolduc, J.M, Dyer, D.H, Scott, W.G, Singer, P, Sweet, R.M, Koshland Junior, D.E, Stoddard, B.L. | | 登録日 | 1995-01-18 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
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1P2Z
 | | Refinement of Adenovirus Type 2 Hexon with CNS | | 分子名称: | CITRIC ACID, Hexon protein | | 著者 | Rux, J.J, Kuser, P.R, Burnett, R.M. | | 登録日 | 2003-04-16 | | 公開日 | 2003-11-11 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural and phylogenetic analysis of adenovirus hexons by use of
high-resolution x-ray crystallographic, molecular modeling, and sequence-based
methods
J.VIROL., 77, 2003
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1TSX
 | | THYMIDYLATE SYNTHASE R179E MUTANT | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | | 著者 | Finer-Moore, J, Stroud, R.M. | | 登録日 | 1995-12-05 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein Eng., 9, 1996
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3NG1
 | | N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS | | 分子名称: | 1,2-ETHANEDIOL, CADMIUM ION, SIGNAL SEQUENCE RECOGNITION PROTEIN FFH, ... | | 著者 | Freymann, D.M, Stroud, R.M, Walter, P. | | 登録日 | 1998-09-13 | | 公開日 | 1999-07-30 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP.
Nat.Struct.Biol., 6, 1999
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1TVU
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1PGG
 | | PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), TRANS MODEL | | 分子名称: | 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Loll, P.J, Picot, D, Garavito, R.M. | | 登録日 | 1995-12-02 | | 公開日 | 1997-01-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | | 主引用文献 | Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.
Biochemistry, 35, 1996
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1PGF
 | | PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL | | 分子名称: | 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Loll, P.J, Picot, D, Garavito, R.M. | | 登録日 | 1995-12-02 | | 公開日 | 1997-01-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | | 主引用文献 | Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.
Biochemistry, 35, 1996
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1TVV
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1TVW
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1TSZ
 | | THYMIDYLATE SYNTHASE R179K MUTANT | | 分子名称: | PHOSPHATE ION, THYMIDYLATE SYNTHASE | | 著者 | Finer-Moore, J, Stroud, R.M. | | 登録日 | 1995-12-05 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein Eng., 9, 1996
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1TSW
 | | THYMIDYLATE SYNTHASE R179A MUTANT | | 分子名称: | PHOSPHATE ION, THYMIDYLATE SYNTHASE | | 著者 | Finer-Moore, J, Stroud, R.M. | | 登録日 | 1995-12-05 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein Eng., 9, 1996
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1DTT
 | | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94) | | 分子名称: | HIV-1 RT A-CHAIN, HIV-1 RT B-CHAIN, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-CHLORO-PYRIDYL]-THIOUREA | | 著者 | Ren, J, Diprose, J, Warren, J, Esnouf, R.M, Bird, L.E, Ikemizu, S, Slater, M, Milton, J, Balzarini, J, Stuart, D.I, Stammers, D.K. | | 登録日 | 2000-01-13 | | 公開日 | 2000-04-02 | | 最終更新日 | 2014-11-12 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
J.Biol.Chem., 275, 2000
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1TRG
 | | E. COLI THYMIDYLATE SYNTHASE IN SYMMETRIC COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | | 著者 | Stout, T.J, Sage, C.R, Stroud, R.M. | | 登録日 | 1998-05-21 | | 公開日 | 1998-08-12 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The additivity of substrate fragments in enzyme-ligand binding.
Structure, 6, 1998
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1DTQ
 | | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94) | | 分子名称: | HIV-1 RT A-CHAIN, HIV-1 RT B-CHAIN, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-NITRILOMETHYL-PYRIDYL]-THIOUREA | | 著者 | Ren, J, Diprose, J, Warren, J, Esnouf, R.M, Bird, L.E, Ikemizu, S, Slater, M, Milton, J, Balzarini, J, Stuart, D.I, Stammers, D.K. | | 登録日 | 2000-01-13 | | 公開日 | 2000-03-20 | | 最終更新日 | 2014-11-12 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
J.Biol.Chem., 275, 2000
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1TSY
 | | THYMIDYLATE SYNTHASE R179K MUTANT | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | | 著者 | Finer-Moore, J, Stroud, R.M. | | 登録日 | 1995-12-05 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein Eng., 9, 1996
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1TSV
 | | THYMIDYLATE SYNTHASE R179A MUTANT | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | | 著者 | Finer-Moore, J, Stroud, R.M. | | 登録日 | 1995-12-05 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein Eng., 9, 1996
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1P30
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1IRL
 | | THE SOLUTION STRUCTURE OF THE F42A MUTANT OF HUMAN INTERLEUKIN 2 | | 分子名称: | INTERLEUKIN-2 | | 著者 | Mott, H.R, Baines, B.S, Hall, R.M, Cooke, R.M, Driscoll, P.C, Weir, M.P, Campbell, I.D. | | 登録日 | 1995-08-25 | | 公開日 | 1995-12-07 | | 最終更新日 | 2021-11-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The solution structure of the F42A mutant of human interleukin 2.
J.Mol.Biol., 247, 1995
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1SJS
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5UVF
 | | Crystal Structure of the Human vaccinia-related kinase bound to BI-D1870 | | 分子名称: | (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Counago, R.M, Bountra, C, Arruda, P, Edwards, A.M, Gileadi, O, Structural Genomics Consortium (SGC) | | 登録日 | 2017-02-20 | | 公開日 | 2017-03-22 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep, 7, 2017
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