6M9M
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7KF0
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4MKP
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![BU of 4mkp by Molmil](/molmil-images/mine/4mkp) | Crystal structure of human cGAS apo form | Descriptor: | Cyclic GMP-AMP synthase, ZINC ION | Authors: | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | Deposit date: | 2013-09-05 | Release date: | 2013-10-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.953 Å) | Cite: | Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS Plos One, 8, 2013
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6MEL
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![BU of 6mel by Molmil](/molmil-images/mine/6mel) | Succinyl-CoA synthase from Campylobacter jejuni | Descriptor: | CHLORIDE ION, CITRIC ACID, Succinate--CoA ligase [ADP-forming] subunit beta, ... | Authors: | Osipiuk, J, Maltseva, N, Jedrzejczak, R, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-09-06 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Succinyl-CoA synthase from Campylobacter jejuni to be published
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5LOS
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![BU of 5los by Molmil](/molmil-images/mine/5los) | Piriformospora indica PIIN_05872 | Descriptor: | PIIN_05872, SULFATE ION, ZINC ION | Authors: | Hartmann, M.D, Albrecht, R, Martin, J, Lupas, A.N. | Deposit date: | 2016-08-09 | Release date: | 2018-05-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A secreted fungal histidine- and alanine-rich protein regulates metal ion homeostasis and oxidative stress. New Phytol., 227, 2020
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6MBV
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6MER
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![BU of 6mer by Molmil](/molmil-images/mine/6mer) | PcdhgB3 EC1-4 in 50 mM HEPES | Descriptor: | CALCIUM ION, Protocadherin gamma-B3 | Authors: | Nicoludis, J.M, Gaudet, R. | Deposit date: | 2018-09-06 | Release date: | 2019-09-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis. Proc.Natl.Acad.Sci.USA, 116, 2019
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2J50
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![BU of 2j50 by Molmil](/molmil-images/mine/2j50) | Structure of Aurora-2 in complex with PHA-739358 | Descriptor: | N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, SERINE/THREONINE-PROTEIN KINASE 6, SULFATE ION | Authors: | Cameron, A.D, Izzo, G, Storici, P, Rusconi, L, Fancelli, D, Varasi, M, Berta, D, Bindi, S, Forte, B, Severino, D, Tonani, R, Vianello, P. | Deposit date: | 2006-09-08 | Release date: | 2006-11-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | 1,4,5,6-Tetrahydropyrrolo[3,4-C]Pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile. J.Med.Chem., 49, 2006
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5LWO
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![BU of 5lwo by Molmil](/molmil-images/mine/5lwo) | Structure of Spin-labelled T4 lysozyme mutant L115C-R119C-R1 at 100K | Descriptor: | 2-HYDROXYETHYL DISULFIDE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | Authors: | Loll, B, Consentius, P, Gohlke, U, Mueller, R, Kaupp, M, Heinemann, U, Wahl, M.C, Risse, T. | Deposit date: | 2016-09-18 | Release date: | 2017-03-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.183 Å) | Cite: | Internal Dynamics of the 3-Pyrroline-N-Oxide Ring in Spin-Labeled Proteins. J Phys Chem Lett, 8, 2017
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4PO4
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6LYM
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![BU of 6lym by Molmil](/molmil-images/mine/6lym) | Crystal structure of D657A mutant of formylglycinamidine synthetase | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | Authors: | Sharma, N, Tanwar, A.S, Anand, R. | Deposit date: | 2020-02-14 | Release date: | 2021-02-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase. Acs Catalysis, 12, 2022
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1R7E
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![BU of 1r7e by Molmil](/molmil-images/mine/1r7e) | NMR structure of the membrane anchor domain (1-31) of the nonstructural protein 5A (NS5A) of hepatitis C virus (Minimized average structure. Sample in 100mM SDS). | Descriptor: | Genome polyprotein | Authors: | Penin, F, Brass, V, Appel, N, Ramboarina, S, Montserret, R, Ficheux, D, Blum, H.E, Bartenschlager, R, Moradpour, D. | Deposit date: | 2003-10-21 | Release date: | 2004-08-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J.Biol.Chem., 279, 2004
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6LYO
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![BU of 6lyo by Molmil](/molmil-images/mine/6lyo) | Crystal Structure of H296A mutant of Formylglycinamidine Synthetase | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | Authors: | Sharma, N, Tanwar, A.S, Anand, R. | Deposit date: | 2020-02-15 | Release date: | 2021-02-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase. Acs Catalysis, 12, 2022
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6LYK
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![BU of 6lyk by Molmil](/molmil-images/mine/6lyk) | Crystal Structure of R1263A mutant of Formylglycinamidine Synthetase | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLUTAMINE, ... | Authors: | Sharma, N, Tanwar, A.S, Anand, R. | Deposit date: | 2020-02-14 | Release date: | 2021-02-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase. Acs Catalysis, 12, 2022
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6LW8
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![BU of 6lw8 by Molmil](/molmil-images/mine/6lw8) | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | Descriptor: | (4R)-4-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, DNA ligase A, GLYCEROL, ... | Authors: | Ramachandran, R, Afsar, M, Shukla, A. | Deposit date: | 2020-02-07 | Release date: | 2021-02-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A. J.Struct.Biol., 213, 2021
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6LYL
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![BU of 6lyl by Molmil](/molmil-images/mine/6lyl) | Crystal structure of S1052D mutant of Formylglycinamidine synthetase | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | Authors: | Sharma, N, Tanwar, A.S, Anand, R. | Deposit date: | 2020-02-14 | Release date: | 2021-02-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase. Acs Catalysis, 12, 2022
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7D96
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5BOK
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4KXY
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![BU of 4kxy by Molmil](/molmil-images/mine/4kxy) | Human transketolase in complex with ThDP analogue (R)-2-(1,2-dihydroxyethyl)-3-deaza-ThDP | Descriptor: | 1,2-ETHANEDIOL, 2-{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-[(1R)-1,2-dihydroxyethyl]-3-methylthiophen-2-yl}ethyl trihydrogen diphosphate, CALCIUM ION, ... | Authors: | Neumann, P, Luedtke, S, Erixon, K.M, Leeper, F, Kluger, R, Ficner, R, Tittmann, K. | Deposit date: | 2013-05-28 | Release date: | 2013-08-21 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate. Nat Chem, 5, 2013
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4QC9
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![BU of 4qc9 by Molmil](/molmil-images/mine/4qc9) | Crystal structure of Vaccinia virus uracil-DNA glycosylase mutant 3GD4 | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Uracil-DNA glycosylase | Authors: | Sartmatova, D, Nash, T, Schormann, N, Nuth, M, Ricciardi, R, Banerjee, S, Chattopadhyay, D. | Deposit date: | 2014-05-09 | Release date: | 2015-05-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.259 Å) | Cite: | Crystal structure of Vaccinia virus uracil-DNA glycosylase mutant 3GD4 To be Published
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1RDW
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![BU of 1rdw by Molmil](/molmil-images/mine/1rdw) | Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Reutzel, R, Yoshioka, C, Govindasamy, L, Yarmola, E.G, Agbandje-Mckenna, M, Bubb, M.R, Mckenna, R. | Deposit date: | 2003-11-06 | Release date: | 2003-12-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer. J.Struct.Biol., 146, 2004
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5M1I
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![BU of 5m1i by Molmil](/molmil-images/mine/5m1i) | Structure of GH36 alpha-galactosidase from Thermotoga maritima in a covalent complex with a cyclopropyl carbasugar. | Descriptor: | (1~{R},2~{S},3~{S},4~{S},6~{R})-4-fluoranyl-1-(hydroxymethyl)bicyclo[4.1.0]heptane-2,3-diol, 1,2-ETHANEDIOL, Alpha-galactosidase, ... | Authors: | Pengelly, R, Gloster, T. | Deposit date: | 2016-10-07 | Release date: | 2016-11-09 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars. Angew.Chem.Int.Ed.Engl., 55, 2016
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4PED
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![BU of 4ped by Molmil](/molmil-images/mine/4ped) | Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthes | Descriptor: | Chaperone activity of bc1 complex-like, mitochondrial, SULFATE ION | Authors: | Bingman, C.A, Smith, R, Joshi, S, Stefely, J.A, Reidenbach, A.G, Ulbrich, A, Oruganty, O, Floyd, B.J, Jochem, A, Saunders, J.M, Johnson, I.E, Wrobel, R.L, Barber, G.E, Lee, D, Li, S, Kannan, N, Coon, J.J, Pagliarini, D.J, Mitochondrial Protein Partnership (MPP) | Deposit date: | 2014-04-22 | Release date: | 2014-11-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Mitochondrial ADCK3 Employs an Atypical Protein Kinase-like Fold to Enable Coenzyme Q Biosynthesis. Mol.Cell, 57, 2015
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6ET8
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![BU of 6et8 by Molmil](/molmil-images/mine/6et8) | Crystal structure of AlbA in complex with albicidin | Descriptor: | Albicidin resistance protein, SULFATE ION, albicidin | Authors: | Driller, R, Rostock, L, Alings, C, Graetz, S, Suessmuth, R, Mainz, A, Wahl, M.C, Loll, B. | Deposit date: | 2017-10-25 | Release date: | 2018-08-15 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular insights into antibiotic resistance - how a binding protein traps albicidin. Nat Commun, 9, 2018
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1R7C
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![BU of 1r7c by Molmil](/molmil-images/mine/1r7c) | NMR structure of the membrane anchor domain (1-31) of the nonstructural protein 5A (NS5A) of hepatitis C virus (Minimized average structure, Sample in 50% tfe) | Descriptor: | Genome polyprotein | Authors: | Penin, F, Brass, V, Appel, N, Ramboarina, S, Montserret, R, Ficheux, D, Blum, H.E, Bartenschlager, R, Moradpour, D. | Deposit date: | 2003-10-21 | Release date: | 2004-08-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J.Biol.Chem., 279, 2004
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