3I9X
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![BU of 3i9x by Molmil](/molmil-images/mine/3i9x) | Crystal structure of a mutT/nudix family protein from Listeria innocua | Descriptor: | GLYCEROL, mutT/nudix family protein | Authors: | Bonanno, J.B, Gilmore, M, Bain, K.T, Miller, S, Romero, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2009-07-13 | Release date: | 2009-07-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a mutT/nudix family protein from Listeria innocua To be Published
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7VEP
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1BY2
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2UW5
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![BU of 2uw5 by Molmil](/molmil-images/mine/2uw5) | Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine | Descriptor: | (2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... | Authors: | Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A. | Deposit date: | 2007-03-19 | Release date: | 2007-05-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery J.Med.Chem., 50, 2007
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2UW7
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![BU of 2uw7 by Molmil](/molmil-images/mine/2uw7) | Structure of PKA-PKB chimera complexed with 4-(4-chloro-phenyl)-4-(4- (1H-pyrazol-4-yl)-phenyl)-piperidine | Descriptor: | 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... | Authors: | Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A. | Deposit date: | 2007-03-19 | Release date: | 2007-05-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery J.Med.Chem., 50, 2007
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2UYE
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![BU of 2uye by Molmil](/molmil-images/mine/2uye) | Double mutant Y110S,F111V DntR from Burkholderia sp. strain DNT in complex with thiocyanate | Descriptor: | GLYCEROL, REGULATORY PROTEIN, THIOCYANATE ION | Authors: | Lonneborg, R, Smirova, I, Dian, C, leonard, G.A, McSweeney, S, Brzezinski, P. | Deposit date: | 2007-04-04 | Release date: | 2007-08-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | In Vivo and in Vitro Investigation of Transcriptional Regulation by Dntr. J.Mol.Biol., 372, 2007
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7B22
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![BU of 7b22 by Molmil](/molmil-images/mine/7b22) | Vibrio cholerae ParD2 Antitoxin | Descriptor: | Antitoxin ParD | Authors: | Garcia-Rodriguez, G, Loris, R. | Deposit date: | 2020-11-25 | Release date: | 2021-10-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.08 Å) | Cite: | Entropic pressure controls the oligomerization of the Vibrio cholerae ParD2 antitoxin. Acta Crystallogr D Struct Biol, 77, 2021
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1BLA
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![BU of 1bla by Molmil](/molmil-images/mine/1bla) | BASIC FIBROBLAST GROWTH FACTOR (FGF-2) MUTANT WITH CYS 78 REPLACED BY SER AND CYS 96 REPLACED BY SER, NMR | Descriptor: | BASIC FIBROBLAST GROWTH FACTOR | Authors: | Powers, R, Seddon, A.P, Bohlen, P, Moy, F.J. | Deposit date: | 1996-05-20 | Release date: | 1996-11-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | High-resolution solution structure of basic fibroblast growth factor determined by multidimensional heteronuclear magnetic resonance spectroscopy. Biochemistry, 35, 1996
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7VPY
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![BU of 7vpy by Molmil](/molmil-images/mine/7vpy) | Crystal structure of the neutralizing nanobody P86 against SARS-CoV-2 | Descriptor: | 1,2-ETHANEDIOL, Nanobody, SULFATE ION | Authors: | Maeda, R, Fujita, J, Konishi, Y, Kazuma, Y, Yamazaki, H, Anzai, I, Yamaguchi, K, Kasai, K, Nagata, K, Yamaoka, Y, Miyakawa, K, Ryo, A, Shirakawa, K, Makino, F, Matsuura, Y, Inoue, T, Imura, A, Namba, K, Takaori-Kondo, A. | Deposit date: | 2021-10-18 | Release date: | 2022-07-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron. Commun Biol, 5, 2022
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7ALQ
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![BU of 7alq by Molmil](/molmil-images/mine/7alq) | human GCH-GFRP inhibitory complex 7-deaza-GTP bound | Descriptor: | 7,8-DIHYDROBIOPTERIN, 7-deaza-GTP, GTP cyclohydrolase 1, ... | Authors: | Ebenhoch, R, Nar, H. | Deposit date: | 2020-10-07 | Release date: | 2021-10-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.205 Å) | Cite: | Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP. J.Struct.Biol., 213, 2021
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2V12
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![BU of 2v12 by Molmil](/molmil-images/mine/2v12) | Crystal Structure of Renin with Inhibitor 8 | Descriptor: | N-[(2S,4S,5S,7R)-4-AMINO-8-(BUTYLAMINO)-5-HYDROXY-7-METHYL-2-(1-METHYLETHYL)-8-OXOOCTYL]-2-(3-METHOXYPROPOXY)BENZAMIDE, RENIN | Authors: | Rahuel, J, Rasetti, V, Maibaum, J, Rueger, H, Goschke, R, Cohen, N.C, Stutz, S, Cumin, F, Fuhrer, W, Wood, J.M, Grutter, M.G. | Deposit date: | 2007-05-21 | Release date: | 2007-07-03 | Last modified: | 2019-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure-Based Drug Design: The Discovery of Novel Nonpeptide Orally Active Inhibitors of Human Renin Chem.Biol., 7, 2000
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7VPB
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![BU of 7vpb by Molmil](/molmil-images/mine/7vpb) | Crystal structure of a novel hydrolase in apo form | Descriptor: | 4-(2-hydroxyethylcarbamoyl)benzoic acid, ACETATE ION, plastic degrading hydrolase Ple629 | Authors: | Wu, P, Zhao, Y.P, Li, Z.S, Ingrid, M.C, Lara, P, Gao, J, Han, X, Li, Q, Basak, O, Liu, W.D, Wei, R. | Deposit date: | 2021-10-15 | Release date: | 2022-10-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structural insight and engineering of a plastic degrading hydrolase Ple629. Biochem.Biophys.Res.Commun., 626, 2022
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2UZR
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![BU of 2uzr by Molmil](/molmil-images/mine/2uzr) | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K) | Descriptor: | RAC-alpha serine/threonine-protein kinase | Authors: | Carpten, J.D, Faber, A.L, Horn, C, Donoho, G.P, Briggs, S.L, Robbins, C.M, Hostetter, G, Boguslawski, S, Moses, T.Y, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, Y.W, Zeckner, D.J, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, M.H, Blanchard, K.L, Thomas, J.E. | Deposit date: | 2007-05-01 | Release date: | 2007-07-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature, 448, 2007
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7VGK
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![BU of 7vgk by Molmil](/molmil-images/mine/7vgk) | Crystal structure of Lactobacillus rhamnosus 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase KduI | Descriptor: | 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase | Authors: | Iwase, H, Oiki, S, Mikami, B, Takase, R, Hashimoto, W. | Deposit date: | 2021-09-16 | Release date: | 2022-10-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structures of Lacticaseibacillus 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase KduI in complex with substrate analogs J.Appl.Glyosci., 2023
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7AUG
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![BU of 7aug by Molmil](/molmil-images/mine/7aug) | Crystal structure of rsGCamP1.3 in the ON state | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, FORMIC ACID, ... | Authors: | Janowski, R, Fuenzalida-Werner, J.P, Mishra, K, Stiel, A.C, Niessing, D. | Deposit date: | 2020-11-03 | Release date: | 2021-10-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Genetically encoded photo-switchable molecular sensors for optoacoustic and super-resolution imaging. Nat.Biotechnol., 40, 2022
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2UY5
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![BU of 2uy5 by Molmil](/molmil-images/mine/2uy5) | ScCTS1_kinetin crystal structure | Descriptor: | ENDOCHITINASE, N-(FURAN-2-YLMETHYL)-7H-PURIN-6-AMINE | Authors: | Hurtado-Guerrero, R, van Aalten, D.M.F. | Deposit date: | 2007-04-02 | Release date: | 2007-04-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of Saccharomyces Cerevisiae Chitinase 1 and Screening-Based Discovery of Potent Inhibitors. Chem.Biol., 14, 2007
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2VN7
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![BU of 2vn7 by Molmil](/molmil-images/mine/2vn7) | Glycoside Hydrolase Family 15 Glucoamylase from Hypocrea jecorina | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Bott, R, Sandgren, M, Hansson, H. | Deposit date: | 2008-01-31 | Release date: | 2008-05-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Three-Dimensional Structure of an Intact Glycoside Hydrolase Family 15 Glucoamylase from Hypocrea Jecorina. Biochemistry, 47, 2008
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7ARN
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![BU of 7arn by Molmil](/molmil-images/mine/7arn) | Crystal Structure of the Fab Fragment of a Glycosylated Lymphoma Antibody | Descriptor: | Antibody Fab Fragment Heavy Chain, Antibody Fab Fragment Light Chain, GLYCEROL, ... | Authors: | Pryce, R, Allen, J.D, Watanabe, Y, Crispin, M, Bowden, T.A. | Deposit date: | 2020-10-25 | Release date: | 2021-11-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Crystal Structure of the Fab Fragment of a Glycosylated Lymphoma Antibody To Be Published
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7VXT
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![BU of 7vxt by Molmil](/molmil-images/mine/7vxt) | Crystal structure of a selenomethionine-labeled BPSL1038 from Burkholderia pseudomallei | Descriptor: | BETA-MERCAPTOETHANOL, BPSL1038, SODIUM ION | Authors: | Shaibullah, S, Mohd-Sharif, M, Ho, K.L, Firdaus-Raih, M, Nathan, S, Mohamed, R, Teh, A.K, Waterman, J, Ng, C.L. | Deposit date: | 2021-11-13 | Release date: | 2023-08-16 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structural and functional analyses of Burkholderia pseudomallei BPSL1038 reveal a Cas-2/VapD nuclease sub-family. Commun Biol, 6, 2023
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2UZT
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![BU of 2uzt by Molmil](/molmil-images/mine/2uzt) | PKA structures of AKT, indazole-pyridine inhibitors | Descriptor: | (2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... | Authors: | Zhu, G.D, Gandhi, V.B, Gong, J, Thomas, S, Woods, K.W, Song, X, Li, T, Diebold, R.B, Luo, Y, Liu, X, Guan, R, Klinghofer, V, Johnson, E.F, Bouska, J, Olson, A, Marsh, K.C, Stoll, V.S, Mamo, M, Polakowski, J, Campbell, T.J, Penning, T.D, Li, Q, Rosenberg, S.H, Giranda, V.L. | Deposit date: | 2007-05-01 | Release date: | 2007-06-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension. J.Med.Chem., 50, 2007
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2UZU
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![BU of 2uzu by Molmil](/molmil-images/mine/2uzu) | PKA structures of indazole-pyridine series of AKT inhibitors | Descriptor: | (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... | Authors: | Zhu, G.D, Gandhi, V.B, Gong, J, Thomas, S, Woods, K.W, Song, X, Li, T, Diebold, R.B, Luo, Y, Liu, X, Guan, R, Klinghofer, V, Johnson, E.F, Bouska, J, Olson, A, Marsh, K.C, Stoll, V.S, Mamo, M, Polakowski, J, Campbell, T.J, Penning, T.D, Li, Q, Rosenberg, S.H, Giranda, V.L. | Deposit date: | 2007-05-01 | Release date: | 2007-06-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension. J.Med.Chem., 50, 2007
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2VLG
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![BU of 2vlg by Molmil](/molmil-images/mine/2vlg) | KinA PAS-A domain, homodimer | Descriptor: | ACETATE ION, CHLORIDE ION, SPORULATION KINASE A | Authors: | Lee, J, Tomchick, D.R, Brautigam, C.A, Machius, M, Kort, R, Hellingwerf, K.J, Gardner, K.H. | Deposit date: | 2008-01-14 | Release date: | 2008-03-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Changes at the Kina Pas-A Dimerization Interface Influence Histidine Kinase Function. Biochemistry, 47, 2008
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2VMH
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![BU of 2vmh by Molmil](/molmil-images/mine/2vmh) | The structure of CBM51 from Clostridium perfringens GH95 | Descriptor: | CALCIUM ION, FIBRONECTIN TYPE III DOMAIN PROTEIN | Authors: | Gregg, K, Finn, R, Abbott, D.W, Boraston, A.B. | Deposit date: | 2008-01-25 | Release date: | 2008-02-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Divergent Modes of Glycan Recognition by a New Family of Carbohydrate-Binding Modules J.Biol.Chem., 283, 2008
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2UZV
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![BU of 2uzv by Molmil](/molmil-images/mine/2uzv) | PKA structures of indazole-pyridine series of AKT inhibitors | Descriptor: | (2S)-1-[3-(CYCLOHEXYLMETHOXY)PHENYL]-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA,, CAMP-DEPENDENT PROTEIN KINASE, ... | Authors: | Zhu, G.D, Gandhi, V.B, Gong, J, Thomas, S, Woods, K.W, Song, X, Li, T, Diebold, R.B, Luo, Y, Liu, X, Guan, R, Klinghofer, V, Johnson, E.F, Bouska, J, Olson, A, Marsh, K.C, Stoll, V.S, Mamo, M, Polakowski, J, Campbell, T.J, Penning, T.D, Li, Q, Rosenberg, S.H, Giranda, V.L. | Deposit date: | 2007-05-01 | Release date: | 2007-06-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension. J.Med.Chem., 50, 2007
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7BPZ
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![BU of 7bpz by Molmil](/molmil-images/mine/7bpz) | X-ray structure of human PPARalpha ligand binding domain-bezafibrate-SRC1 coactivator peptide co-crystals obtained by soaking | Descriptor: | 15-meric peptide from Nuclear receptor coactivator 1, 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID, Peroxisome proliferator-activated receptor alpha | Authors: | Kamata, S, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I. | Deposit date: | 2020-03-23 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
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