2WHH
 
 | | HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule | | 分子名称: | GLUTAMIC ACID, PARA-NITROPHENYLALANINE, POL PROTEIN | | 著者 | Prashar, V, Bihani, S, Das, A, Ferrer, J.L, Hosur, M.V. | | 登録日 | 2009-05-05 | | 公開日 | 2009-12-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Catalytic Water Co-Existing with a Product Peptide in the Active Site of HIV-1 Protease Revealed by X- Ray Structure Analysis.
Plos One, 4, 2009
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4Q5M
 | | D30N tethered HIV-1 protease dimer/saquinavir complex | | 分子名称: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, Protease | | 著者 | Prashar, V, Bihani, S.C, Ferrer, J.L, Hosur, M.V. | | 登録日 | 2014-04-17 | | 公開日 | 2015-04-08 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | | 主引用文献 | Structural Basis of Why Nelfinavir-Resistant D30N Mutant of HIV-1 Protease Remains Susceptible to Saquinavir.
Chem.Biol.Drug Des., 86, 2015
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3N3I
 | | Crystal Structure of G48V/C95F tethered HIV-1 Protease/Saquinavir complex | | 分子名称: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, Protease | | 著者 | Prashar, V, Bihani, S.C, Das, A, Rao, D.R, Hosur, M.V. | | 登録日 | 2010-05-20 | | 公開日 | 2010-06-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | | 主引用文献 | Insights into the mechanism of drug resistance: X-ray structure analysis of G48V/C95F tethered HIV-1 protease dimer/saquinavir complex
Biochem.Biophys.Res.Commun., 396, 2010
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3DOX
 | | X-ray structure of HIV-1 protease in situ product complex | | 分子名称: | A PEPTIDE SUBSTRATE-PIV, A PEPTIDE SUBSTRATE-SQNY, HIV-1 PROTEASE | | 著者 | Hosur, M.V, Ferrer, J.-L, Das, A, Prashar, V, Bihani, S. | | 登録日 | 2008-07-07 | | 公開日 | 2008-09-09 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | X-ray structure of HIV-1 protease in situ product complex
Proteins, 74, 2009
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5YRS
 | | X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Its SIHB with Catalytic Aspartate | | 分子名称: | PROTEASE, RT-RH oligopeprtide | | 著者 | Das, A, Mahale, S, Prashar, V, Bihani, S, Ferrer, J.-L, Hosur, M.V. | | 登録日 | 2017-11-10 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | X-ray snapshot of HIV-1 protease in action: observation of tetrahedral intermediate and short ionic hydrogen bond SIHB with catalytic aspartate.
J. Am. Chem. Soc., 132, 2010
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2NPH
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3KT5
 | | Crystal Structure of N88S mutant HIV-1 Protease | | 分子名称: | Protease | | 著者 | Bihani, S.C, Das, A, Prashar, V, Ferrer, J.L, Hosur, M.V. | | 登録日 | 2009-11-24 | | 公開日 | 2010-02-16 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | | 主引用文献 | Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S.
Biochem.Biophys.Res.Commun., 389, 2009
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3KT2
 | | Crystal Structure of N88D mutant HIV-1 Protease | | 分子名称: | Protease | | 著者 | Bihani, S.C, Das, A, Prashar, V, Ferrer, J.L, Hosur, M.V. | | 登録日 | 2009-11-24 | | 公開日 | 2010-02-16 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | | 主引用文献 | Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S.
Biochem.Biophys.Res.Commun., 389, 2009
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