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3N3I

Crystal Structure of G48V/C95F tethered HIV-1 Protease/Saquinavir complex

Summary for 3N3I
Entry DOI10.2210/pdb3n3i/pdb
Related PRD IDPRD_000454
DescriptorProtease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total)
Functional Keywordshiv-1 protease, saquinavir, drug resistance, tethered-dimer, fusion protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus type 1 (HIV-1)
More
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains1
Total formula weight22749.83
Authors
Prashar, V.,Bihani, S.C.,Das, A.,Rao, D.R.,Hosur, M.V. (deposition date: 2010-05-20, release date: 2010-06-09, Last modification date: 2024-03-20)
Primary citationPrashar, V.,Bihani, S.C.,Das, A.,Rao, D.R.,Hosur, M.V.
Insights into the mechanism of drug resistance: X-ray structure analysis of G48V/C95F tethered HIV-1 protease dimer/saquinavir complex
Biochem.Biophys.Res.Commun., 396:1018-1023, 2010
Cited by
PubMed: 20471372
DOI: 10.1016/j.bbrc.2010.05.049
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.501 Å)
Structure validation

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