3N3I

Crystal Structure of G48V/C95F tethered HIV-1 Protease/Saquinavir complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ROC A 201

Chain	Residue
A	ASP25
A	PRO81
A	VAL82
A	ARG1008
A	ASP1025
A	GLY1027
A	ALA1028
A	ILE1047
A	VAL1048
A	GLY1049
A	ILE1050
A	GLY27
A	HOH1100
A	HOH1101
A	ALA28
A	ASP29
A	ASP30
A	ILE47
A	VAL48
A	GLY49
A	ILE50

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL

Chain	Residue	Details
A	ALA22-LEU33
A	ALA1022-LEU1033

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000305|PubMed:33542150

Chain	Residue	Details
A	ASP1025

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by viral protease => ECO:0000250

Chain	Residue	Details
A	PHE1099

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 175

Chain	Residue	Details
A	ASP1025	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	THR1026	electrostatic stabiliser, transition state stabiliser
A	GLY1027	electrostatic stabiliser, hydrogen bond donor

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