3KT2

Crystal Structure of N88D mutant HIV-1 Protease

Summary for 3KT2

• Entry DOI: 10.2210/pdb3kt2/pdb
• Related: 3KT5
• Descriptor: Protease (2 entities in total)
• Functional Keywords: drug resistant mutation, n88d, nelfinavir, hiv-1 protease, hydrolase, protease
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• Total number of polymer chains: 1
• Total formula weight: 21964.85

Authors

Bihani, S.C.,Das, A.,Prashar, V.,Ferrer, J.L.,Hosur, M.V. (deposition date: 2009-11-24, release date: 2010-02-16, Last modification date: 2021-11-10)

• Primary citation: Bihani, S.C.,Das, A.,Prashar, V.,Ferrer, J.L.,Hosur, M.V.; Resistance mechanism revealed by crystal structures of unliganded nelfinavir-resistant HIV-1 protease non-active site mutants N88D and N88S.; Biochem.Biophys.Res.Commun., 389:295-300, 2009; PubMed: 19720046; DOI: 10.1016/j.bbrc.2009.08.138

Experimental method

X-RAY DIFFRACTION (1.651 Å)