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PDB: 54 件
8PBC
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BU of 8pbc by Molmil
RAD51 filament on ssDNA bound by the BRCA2 c-terminus
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Breast cancer type 2 susceptibility protein, CALCIUM ION, ...
著者Appleby, R, Pellegrini, L.
登録日2023-06-09
公開日2023-11-15
実験手法ELECTRON MICROSCOPY (2.61 Å)
主引用文献Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2.
Nat Commun, 14, 2023
8PBD
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BU of 8pbd by Molmil
RAD51 filament on dsDNA bound by the BRCA2 c-terminus
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Breast cancer type 2 susceptibility protein, CALCIUM ION, ...
著者Appleby, R, Pellegrini, L.
登録日2023-06-09
公開日2023-11-15
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2.
Nat Commun, 14, 2023
1PWA
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BU of 1pwa by Molmil
Crystal structure of Fibroblast Growth Factor 19
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Fibroblast growth factor-19, GLYCEROL, ...
著者Harmer, N.J, Pellegrini, L, Chirgadze, D, Fernandez-Recio, J, Blundell, T.L.
登録日2003-07-01
公開日2004-01-27
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.
Biochemistry, 43, 2004
6XTY
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BU of 6xty by Molmil
CryoEM structure of human CMG bound to AND-1 (CMGA)
分子名称: Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
著者Rzechorzek, N.J, Pellegrini, L, Chirgadze, D.Y, Hardwick, S.W.
登録日2020-01-16
公開日2020-05-27
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (6.77 Å)
主引用文献CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes.
Nucleic Acids Res., 48, 2020
8QJ7
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BU of 8qj7 by Molmil
Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ...
著者Yin, Z, Pellegrini, L.
登録日2023-09-12
公開日2024-02-21
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献CryoEM insights into RNA primer synthesis by the human primosome.
Febs J., 291, 2024
2YGK
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BU of 2ygk by Molmil
Crystal structure of the NurA nuclease from Sulfolobus solfataricus
分子名称: MANGANESE (II) ION, NURA
著者Rzechorzek, N.J, Blackwood, J.K, Abrams, A.S, Maman, J.D, Robinson, N.P, Pellegrini, L.
登録日2011-04-18
公開日2011-12-14
最終更新日2012-04-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and Functional Insights Into DNA-End Processing by the Archaeal Hera Helicase-Nura Nuclease Complex.
Nucleic Acids Res., 40, 2012
3C1D
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BU of 3c1d by Molmil
X-ray crystal structure of RecX
分子名称: Regulatory protein recX
著者Ragone, S, Maman, J.D, Furnham, N, Pellegrini, L.
登録日2008-01-23
公開日2008-07-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for inhibition of homologous recombination by the RecX protein.
Embo J., 27, 2008
3FLO
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BU of 3flo by Molmil
Crystal structure of the carboxyl-terminal domain of yeast DNA polymerase alpha in complex with its B subunit
分子名称: DNA polymerase alpha catalytic subunit A, DNA polymerase alpha subunit B, SULFATE ION, ...
著者Klinge, S.N, Pellegrini, L.
登録日2008-12-19
公開日2009-06-09
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases
Embo J., 28, 2009
1Z56
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BU of 1z56 by Molmil
Co-Crystal Structure of Lif1p-Lig4p
分子名称: DNA ligase IV, Ligase interacting factor 1
著者Dore, A.S, Furnham, N, Davies, O.R, Sibanda, B.L, Chirgadze, D.Y, Jackson, S.P, Pellegrini, L, Blundell, T.L.
登録日2005-03-17
公開日2006-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.92 Å)
主引用文献Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA REPAIR, 5, 2006
1ZT2
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BU of 1zt2 by Molmil
Heterodimeric structure of the core primase.
分子名称: DNA primase large subunit, DNA primase small subunit, SULFATE ION, ...
著者Lao-Sirieix, S.H, Nookala, R.K, Roversi, P, Bell, S.D, Pellegrini, L.
登録日2005-05-26
公開日2005-11-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Structure of the heterodimeric core primase.
Nat.Struct.Mol.Biol., 12, 2005
1IK9
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BU of 1ik9 by Molmil
CRYSTAL STRUCTURE OF A XRCC4-DNA LIGASE IV COMPLEX
分子名称: DNA LIGASE IV, DNA REPAIR PROTEIN XRCC4
著者Sibanda, B.L, Critchlow, S.E, Begun, J, Pei, X.Y, Jackson, S.P, Blundell, T.L, Pellegrini, L.
登録日2001-05-03
公開日2001-11-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of an Xrcc4-DNA ligase IV complex.
Nat.Struct.Biol., 8, 2001
6TAZ
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BU of 6taz by Molmil
Timeless couples G quadruplex detection with processing by DDX11 during DNA replication
分子名称: Protein timeless homolog
著者Lerner Koch, L, Holzer, S, Kilkenny, M.L, Murat, P, Svikovic, S, Schiavone, D, Bittleston, A, Maman, J.D, Branzei, D, Stott, K, Pellegrini, L, Sale, E.J.
登録日2019-10-31
公開日2020-07-01
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.
Embo J., 39, 2020
4FYD
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BU of 4fyd by Molmil
Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA and dGTP
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*GP*AP*GP*CP*GP*TP*G*TP*GP*TP*AP*CP*CP*CP*CP*TP*GP*CP*CP*CP*GP*CP*CP*G)-3'), DNA polymerase alpha catalytic subunit A, ...
著者Perera, R.L, Pellegrini, L.
登録日2012-07-04
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
eLife, 2, 2013
4FVM
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BU of 4fvm by Molmil
Crystal structure of yeast DNA polymerase alpha
分子名称: DNA polymerase alpha catalytic subunit A
著者Perera, R.L, Pellegrini, L.
登録日2012-06-29
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
eLife, 2, 2013
4FXD
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BU of 4fxd by Molmil
Crystal structure of yeast DNA polymerase alpha bound to DNA/RNA
分子名称: DNA (5'-D(*TP*TP*TP*TP*CP*GP*CP*TP*GP*CP*CP*CP*GP*CP*CP*T)-3'), DNA polymerase alpha catalytic subunit A, RNA (5'-R(*AP*GP*GP*CP*GP*GP*GP*CP*AP*G)-3')
著者Perera, R.L, Torella, R, Klinge, S, Kilkenny, M.L, Maman, J.D, Pellegrini, L.
登録日2012-07-03
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
eLife, 2, 2013
5NXQ
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BU of 5nxq by Molmil
Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to a stapled Sld5 CIP
分子名称: DNA polymerase alpha-binding protein, GLYCEROL, MET-ASP-ILE-UA1-ILE-ASP-ASP-ILE-LEU-UA2-GLU-LEU-ASP-LYS-GLU
著者Wu, Y, Pellegrini, L.
登録日2017-05-10
公開日2017-08-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.413 Å)
主引用文献Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Angew. Chem. Int. Ed. Engl., 56, 2017
5DGO
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BU of 5dgo by Molmil
Crystal structure of cell division cycle protein 45 (Cdc45)
分子名称: 1,2-ETHANEDIOL, Cell division control protein 45 homolog, SULFATE ION
著者Simon, A.C, Pellegrini, L.
登録日2015-08-28
公開日2016-05-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of human Cdc45 and implications for CMG helicase function.
Nat Commun, 7, 2016
4C8H
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BU of 4c8h by Molmil
Crystal structure of the C-terminal region of yeast Ctf4, selenomethionine protein.
分子名称: CTF4
著者Simon, A.C, Pellegrini, L.
登録日2013-10-01
公開日2014-04-30
最終更新日2014-06-18
実験手法X-RAY DIFFRACTION (2.691 Å)
主引用文献A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase Alpha in the Eukaryotic Replisome
Nature, 510, 2014
4C8S
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BU of 4c8s by Molmil
Crystal structure of the C-terminal region of yeast Ctf4
分子名称: DNA POLYMERASE ALPHA-BINDING PROTEIN
著者Simon, A.C, Pellegrini, L.
登録日2013-10-01
公開日2014-04-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
4C95
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BU of 4c95 by Molmil
Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Sld5
分子名称: DNA POLYMERASE ALPHA-BINDING PROTEIN, DNA REPLICATION COMPLEX GINS PROTEIN SLD5
著者Simon, A.C, Pellegrini, L.
登録日2013-10-02
公開日2014-04-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.694 Å)
主引用文献A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
4C93
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BU of 4c93 by Molmil
Crystal structure of the carboxy-terminal domain of yeast Ctf4 bound to Pol alpha.
分子名称: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT A, DNA POLYMERASE ALPHA-BINDING PROTEIN
著者Simon, A.C, Pellegrini, L.
登録日2013-10-02
公開日2014-04-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.694 Å)
主引用文献A Ctf4 Trimer Couples the Cmg Helicase to DNA Polymerase a in the Eukaryotic Replisome
Nature, 510, 2014
5MQI
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BU of 5mqi by Molmil
Crystal structure of the N-terminal domain of human Timeless
分子名称: Protein timeless homolog,Protein timeless homolog, SULFATE ION
著者Holzer, S, Kilkenny, M.L, Pellegrini, L.
登録日2016-12-20
公開日2017-03-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.847 Å)
主引用文献Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.
Nucleic Acids Res., 45, 2017
4D2I
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BU of 4d2i by Molmil
Crystal structure of the HerA hexameric DNA translocase from Sulfolobus solfataricus bound to AMP-PNP
分子名称: HERA, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Rzechorzek, N.J, Blackwood, J.K, Bray, S.M, Maman, J.D, Pellegrini, L, Robinson, N.P.
登録日2014-05-09
公開日2014-12-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.841 Å)
主引用文献Structure of the Hexameric Hera ATPase Reveals a Mechanism of Translocation-Coupled DNA-End Processing in Archaea
Nat.Commun., 5, 2014
4BPU
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BU of 4bpu by Molmil
Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL lacking the C-terminal Fe-S domain.
分子名称: DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, GLYCEROL, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
4CPC
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BU of 4cpc by Molmil
Crystal structure of human synaptonemal complex protein SYCP3
分子名称: SYNAPTONEMAL COMPLEX PROTEIN 3
著者Syrjanen, J.L, Pellegrini, L, Davies, O.R.
登録日2014-02-05
公開日2014-07-02
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献A molecular model for the role of SYCP3 in meiotic chromosome organisation.
Elife, 3, 2014

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