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PDB: 151 件
6RML
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Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide
分子名称: 53BP1, DNA topoisomerase 2-binding protein 1
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2019-05-07
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
6RMM
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Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide
分子名称: 53BP1, DNA topoisomerase 2-binding protein 1
著者Day, M, Oliver, A.W, Pearl, L.H.
登録日2019-05-07
公開日2019-06-12
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.53 Å)
主引用文献Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
6HM4
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Crystal structure of Rad4 BRCT1,2 in complex with a Mdb1 phosphopeptide
分子名称: 1,2-ETHANEDIOL, ACETATE ION, DNA damage response protein Mdb1, ...
著者Day, M, Rappas, M, Oliver, A.W, Pearl, L.H.
登録日2018-09-12
公開日2018-10-17
実験手法X-RAY DIFFRACTION (1.770186 Å)
主引用文献BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.
Elife, 7, 2018
6HM3
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Crystal structure of Rad4 BRCT1,2 in complex with a Sld3 phosphopeptide
分子名称: CALCIUM ION, DNA replication regulator sld3, GLYCEROL, ...
著者Day, M, Rappas, M, Oliver, A.W, Pearl, L.H.
登録日2018-09-12
公開日2018-10-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.77263618 Å)
主引用文献BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.
Elife, 7, 2018
1AH8
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STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
分子名称: GLYCEROL, HEAT SHOCK PROTEIN 90
著者Prodromou, C, Roe, S.M, Pearl, L.H.
登録日1997-04-14
公開日1997-10-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1AH6
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STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
分子名称: HEAT SHOCK PROTEIN 90
著者Prodromou, C, Roe, S.M, Pearl, L.H.
登録日1997-04-14
公開日1997-10-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1HK7
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Middle Domain of HSP90
分子名称: CADMIUM ION, HEAT SHOCK PROTEIN HSP82, MAGNESIUM ION
著者Meyer, P, Prodromou, C, Roe, S.M, Pearl, L.H.
登録日2003-03-06
公開日2004-01-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and Functional Analysis of the Middle Segment of Hsp90. Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
Mol.Cell, 11, 2003
1KCF
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Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2
分子名称: HYPOTHETICAL 30.2 KD PROTEIN C25G10.02 IN CHROMOSOME I, SULFATE ION
著者Ceschini, S, Keeley, A, McAlister, M.S.B, Oram, M, Phelan, J, Pearl, L.H, Tsaneva, I.R, Barrett, T.E.
登録日2001-11-08
公開日2001-11-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2.
EMBO J., 20, 2001
1KO9
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Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1
分子名称: 8-oxoguanine DNA glycosylase, SULFATE ION
著者Bjoras, M, Seeberg, E, Luna, L, Pearl, L.H, Barrett, T.E.
登録日2001-12-20
公開日2002-01-09
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase.
J.Mol.Biol., 317, 2002
1UV5
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GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 6-BROMOINDIRUBIN-3'-OXIME
分子名称: 6-BROMOINDIRUBIN-3'-OXIME, CHLORIDE ION, COBALT (II) ION, ...
著者Dajani, R, Pearl, L.H, Roe, S.M.
登録日2004-01-14
公開日2004-01-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Gsk-3-Selective Inhibitors Derived from Tyrian Purple Indurubins
Chem.Biol., 10, 2003
2CE9
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A WRPW peptide bound to the Groucho-TLE WD40 domain.
分子名称: TRANSDUCIN-LIKE ENHANCER PROTEIN 1, WRPW PEPTIDE
著者Pickles, L.M, Roe, S.M, Pearl, L.H.
登録日2006-02-03
公開日2006-06-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Molecular Recognition of Transcriptional Repressor Motifs by the Wd Domain of the Groucho/Tle Corepressor.
Mol.Cell, 22, 2006
2IWS
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Radicicol analogues bound to the ATP site of HSP90
分子名称: (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2006-07-04
公開日2006-11-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2IWX
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Analogues of radicicol bound to the ATP-binding site of Hsp90.
分子名称: (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2006-07-05
公開日2006-11-30
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2CE8
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An EH1 peptide bound to the Groucho-TLE WD40 domain.
分子名称: EH1 PEPTIDE, TRANSDUCIN-LIKE ENHANCER PROTEIN 1
著者Pickles, L.M, Roe, S.M, Pearl, L.H.
登録日2006-02-03
公開日2006-06-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Molecular Recognition of Transcriptional Repressor Motifs by the Wd Domain of the Groucho/Tle Corepressor.
Mol.Cell, 22, 2006
2IZO
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BU of 2izo by Molmil
Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex
分子名称: DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C, FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, ...
著者Dore, A.S, Kilkenny, M.L, Roe, S.M, Pearl, L.H.
登録日2006-07-25
公開日2006-09-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity.
Nucleic Acids Res., 34, 2006
2IWU
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BU of 2iwu by Molmil
Analogues of radicicol bound to the ATP-binding site of Hsp90
分子名称: (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
著者Roe, S.M, Prodromou, C, Pearl, L.H.
登録日2006-07-04
公開日2006-11-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
1USU
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The Structure of the complex between Aha1 and HSP90
分子名称: AHA1, GLYCEROL, HEAT SHOCK PROTEIN HSP82
著者Meyer, P, Roe, S.M, Pearl, L.H.
登録日2003-12-01
公開日2004-01-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Basis for Recruitment of the ATPase Activator Aha1 to the Hsp90 Chaperone Machinery.
Embo J., 23, 2004
1US7
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Complex of Hsp90 and P50
分子名称: HEAT SHOCK PROTEIN HSP82, HSP90 CO-CHAPERONE CDC37
著者Roe, S.M, Ali, M.M.U, Pearl, L.H.
登録日2003-11-20
公開日2004-01-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Mechanism of Hsp90 Regulation by the Protein Kinase-Specific Cochaperone p50(Cdc37)
Cell(Cambridge,Mass.), 116, 2004
1USV
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The Structure of the complex between Aha1 and HSP90
分子名称: AHA1, HEAT SHOCK PROTEIN HSP82
著者Meyer, P, Roe, S.M, Pearl, L.H.
登録日2003-12-01
公開日2004-01-29
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for Recruitment of the ATPase Activator Aha1 to the Hsp90 Chaperone Machinery.
Embo J., 23, 2004
1UNN
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Complex of beta-clamp processivity factor and little finger domain of PolIV
分子名称: DNA POLYMERASE III BETA SUBUNIT, DNA POLYMERASE IV, SULFATE ION
著者Bunting, K.A, Roe, S.M, Pearl, L.H.
登録日2003-09-11
公開日2003-11-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis for Recruitment of Translesion DNA Polymerase Pol Iv/Dinb to the Beta-Clamp
Embo J., 22, 2003
2JKI
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Complex of Hsp90 N-terminal and Sgt1 CS domain
分子名称: ADENOSINE-5'-DIPHOSPHATE, CYTOSOLIC HEAT SHOCK PROTEIN 90, SGT1-LIKE PROTEIN
著者Zhang, M, Pearl, L.H.
登録日2008-08-28
公開日2008-10-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structural and Functional Coupling of Hsp90- and Sgt1-Centred Multi-Protein Complexes.
Embo J., 27, 2008
1A4H
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STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN
分子名称: GELDANAMYCIN, HEAT SHOCK PROTEIN 90
著者Prodromou, C, Roe, S.M, Pearl, L.H.
登録日1998-01-29
公開日1998-08-05
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1GEC
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GLYCYL ENDOPEPTIDASE-COMPLEX WITH BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE COVALENTLY BOUND TO CYSTEINE 25
分子名称: BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE INHIBITOR, GLYCYL ENDOPEPTIDASE
著者Ohara, B.P, Hemmings, A.M, Buttle, D.J, Pearl, L.H.
登録日1995-05-25
公開日1995-12-07
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of glycyl endopeptidase from Carica papaya: a cysteine endopeptidase of unusual substrate specificity.
Biochemistry, 34, 1995
1GML
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crystal structure of the mouse CCT gamma apical domain (triclinic)
分子名称: GLYCEROL, T-COMPLEX PROTEIN 1 SUBUNIT GAMMA
著者Pappenberger, G, Wilsher, J.A, Roe, S.M, Willison, K.R, Pearl, L.H.
登録日2001-09-17
公開日2002-06-18
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the Cct Gamma Apical Domain:: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin
J.Mol.Biol., 318, 2002
1GN1
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crystal structure of the mouse CCT gamma apical domain (monoclinic)
分子名称: CALCIUM ION, CCT-GAMMA
著者Pappenberger, G, Wilsher, J.A, Roe, S.M, Willison, K.R, Pearl, L.H.
登録日2001-10-01
公開日2002-06-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Cct Gamma Apical Domain:: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin
J.Mol.Biol., 318, 2002

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