4QDQ
 
 | | Physical basis for Nrp2 ligand binding | | Descriptor: | GLYCEROL, Neuropilin-2, SULFATE ION | | Authors: | Parker, M.W, Vander Kooi, C.W. | | Deposit date: | 2014-05-14 | | Release date: | 2015-04-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
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4QDR
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4QDS
 | | Physical basis for Nrp2 ligand binding | | Descriptor: | ACETATE ION, GLYCEROL, Neuropilin-2 | | Authors: | Parker, M.W, Vander Kooi, C.W. | | Deposit date: | 2014-05-14 | | Release date: | 2015-04-15 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
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1PRE
 | | PROAEROLYSIN | | Descriptor: | PROAEROLYSIN | | Authors: | Parker, M.W, Buckley, J.T, Postma, J.P.M, Tucker, A.D, Tsernoglou, D. | | Deposit date: | 1995-09-15 | | Release date: | 1996-10-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states.
Nature, 367, 1994
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1Z52
 | | Proaerolysin Mutant W373L | | Descriptor: | Aerolysin | | Authors: | Parker, M.W, Feil, S.C, Tang, J.W. | | Deposit date: | 2005-03-16 | | Release date: | 2006-03-07 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Crystal Structure of Proaerolysin at 2.3 A Resolution and Structural Analyses of Single-site Mutants as a Basis for Understanding Membrane Insertion of the Toxin
To be Published
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5DIM
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5DHL
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1COL
 | | REFINED STRUCTURE OF THE PORE-FORMING DOMAIN OF COLICIN A AT 2.4 ANGSTROMS RESOLUTION | | Descriptor: | COLICIN A | | Authors: | Parker, M.W, Postma, J.P.M, Pattus, F, Tucker, A.D, Tsernoglou, D. | | Deposit date: | 1991-07-06 | | Release date: | 1992-07-15 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Refined structure of the pore-forming domain of colicin A at 2.4 A resolution.
J.Mol.Biol., 224, 1992
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4NKQ
 | | Structure of a Cytokine Receptor Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, ... | | Authors: | Parker, M.W, Broughton, S.E. | | Deposit date: | 2013-11-13 | | Release date: | 2015-09-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.301 Å) | | Cite: | Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
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4ZGH
 | | Structure of Sugar Binding Protein Pneumolysin | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GOLD (I) CYANIDE ION, ... | | Authors: | Parker, M.W, Feil, S.C, Morton, C. | | Deposit date: | 2015-04-23 | | Release date: | 2016-03-09 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
Sci Rep, 5, 2015
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7SIA
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1MWP
 | | N-TERMINAL DOMAIN OF THE AMYLOID PRECURSOR PROTEIN | | Descriptor: | AMYLOID A4 PROTEIN | | Authors: | Rossjohn, J, Cappai, R, Feil, S.C, Henry, A, McKinstry, W.J, Galatis, D, Hesse, L, Multhaup, G, Beyreuther, K, Masters, C.L, Parker, M.W. | | Deposit date: | 1999-03-09 | | Release date: | 2000-03-15 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Nat.Struct.Biol., 6, 1999
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2R5G
 | | Structure of human CLIC2, crystal form B | | Descriptor: | Chloride intracellular channel protein 2 | | Authors: | Gorman, M.A, Hansen, G, Cromer, B.A, Parker, M.W. | | Deposit date: | 2007-09-03 | | Release date: | 2007-11-13 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Structure of the Janus Protein Human CLIC2
J.Mol.Biol., 374, 2007
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1EOG
 | | CRYSTAL STRUCTURE OF PI CLASS GLUTATHIONE TRANSFERASE | | Descriptor: | GLUTATHIONE S-TRANSFERASE | | Authors: | Rossjohn, J, McKinstry, W.J, Oakley, A.J, Parker, M.W, Stenberg, G, Mannervik, B, Dragani, B, Cocco, R, Aceto, A. | | Deposit date: | 2000-03-22 | | Release date: | 2000-10-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structures of thermolabile mutants of human glutathione transferase P1-1.
J.Mol.Biol., 302, 2000
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1EOH
 | | GLUTATHIONE TRANSFERASE P1-1 | | Descriptor: | GLUTATHIONE S-TRANSFERASE | | Authors: | Rossjohn, J, McKinstry, W.J, Oakley, A.J, Parker, M.W, Stenberg, G, Mannervik, B, Dragani, B, Cocco, R, Aceto, A. | | Deposit date: | 2000-03-22 | | Release date: | 2000-10-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of thermolabile mutants of human glutathione transferase P1-1.
J.Mol.Biol., 302, 2000
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3N9J
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3CWM
 | | Crystal structure of alpha-1-antitrypsin complexed with citrate | | Descriptor: | Alpha-1-antitrypsin, CITRIC ACID | | Authors: | Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W. | | Deposit date: | 2008-04-22 | | Release date: | 2008-09-23 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
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8G32
 | | Pro-form of a CDCL short from E. anophelis | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | | Authors: | Johnstone, B.A, Christie, M.P, Morton, C.J, Parker, M.W. | | Deposit date: | 2023-02-06 | | Release date: | 2024-02-07 | | Last modified: | 2024-06-26 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria.
Nat Commun, 15, 2024
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8G33
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6XD4
 | | CDC-like protein | | Descriptor: | ACETATE ION, Hemolysin, SODIUM ION | | Authors: | Morton, C.J, Parker, M.W, Lawrence, S.L, Johnstone, B.A, Tweten, R.K. | | Deposit date: | 2020-06-09 | | Release date: | 2021-04-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins.
Mbio, 11, 2020
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5IMT
 | | Toxin receptor complex | | Descriptor: | CD59 glycoprotein, COPPER (II) ION, Intermedilysin, ... | | Authors: | Morton, C.J, Lawrence, S.L, Feil, S.C, Parker, M.W. | | Deposit date: | 2016-03-06 | | Release date: | 2016-08-24 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.7001 Å) | | Cite: | Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
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5IMW
 | | Trapped Toxin | | Descriptor: | Intermedilysin | | Authors: | Lawrence, S.L, Feil, S.C, Morton, C.J, Parker, M.W. | | Deposit date: | 2016-03-07 | | Release date: | 2016-08-24 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
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1ZGN
 | | Crystal Structure of the Glutathione Transferase Pi in Complex with Dinitrosyl-diglutathionyl Iron Complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FE (III) ION, GLUTATHIONE, ... | | Authors: | Parker, L.J, Adams, J.J, Parker, M.W. | | Deposit date: | 2005-04-21 | | Release date: | 2005-11-01 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo
J.Biol.Chem., 280, 2005
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2A2S
 | | Crystal Structure of Human Glutathione Transferase in complex with S-nitrosoglutathione in the absence of reducing agent | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, CALCIUM ION, ... | | Authors: | Parker, L.J, Morton, C.J, Adams, J.J, Parker, M.W. | | Deposit date: | 2005-06-23 | | Release date: | 2006-06-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
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2A2R
 | | Crystal Structure of Glutathione Transferase Pi in complex with S-nitrosoglutathione | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, CALCIUM ION, ... | | Authors: | Parker, L.J, Morton, C.J, Adams, J.J, Parker, M.W. | | Deposit date: | 2005-06-23 | | Release date: | 2006-06-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
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