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PDB: 236 件
6B1U
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Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S.
登録日2017-09-19
公開日2018-04-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4.
Cell Chem Biol, 25, 2018
6B2E
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BU of 6b2e by Molmil
Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator SC4.
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S.
登録日2017-09-19
公開日2018-04-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4.
Cell Chem Biol, 25, 2018
8DFX
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BU of 8dfx by Molmil
Crystal structure of Human BTN2A1-BTN3A1 Ectodomain Complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1
著者Fulford, T.S, Soliman, C, Castle, R.G, Rigau, M, Ruan, Z, Dolezal, O, Seneviratna, R, Brown, H.G, Hanssen, E, Hammet, A, Li, S, Redmond, S.J, Chung, A, Gorman, M.A, Parker, M.W, Patel, O, Peat, T.S, Newman, J, Behren, A, Gherardin, N.A, Godfrey, D.I, Uldrich, A.P.
登録日2022-06-22
公開日2023-07-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (5.55 Å)
主引用文献Vgamma9-Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers
To Be Published
6VQS
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BU of 6vqs by Molmil
HIV Integrase Core domain (IN) in complex with [5-(3-fluorophenyl)-1-benzofuran-3-yl]acetic acid
分子名称: IODIDE ION, Integrase, SULFATE ION, ...
著者Gorman, M.A, Parker, M.W.
登録日2020-02-05
公開日2021-02-10
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献HIV Integrase Core domain (IN) in complex with [5-(3-fluorophenyl)-1-benzofuran-3-yl]acetic acid
To Be Published
6VX2
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BU of 6vx2 by Molmil
HIV Integrase core domain in complex with inhibitor (5-methyl-1-benzofuran-3-yl)acetic acid
分子名称: (5-methyl-1-benzofuran-3-yl)acetic acid, IODIDE ION, Integrase, ...
著者Gorman, M.A, Parker, M.W.
登録日2020-02-21
公開日2021-02-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献HIV Integrase core domain in complex with inhibitor (5-methyl-1-benzofuran-3-yl)acetic acid
To Be Published
5IMW
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BU of 5imw by Molmil
Trapped Toxin
分子名称: Intermedilysin
著者Lawrence, S.L, Feil, S.C, Morton, C.J, Parker, M.W.
登録日2016-03-07
公開日2016-08-24
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
6W0U
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BU of 6w0u by Molmil
HIV Integrase core domain in complex with inhibitor 2-(2-ethynyl-5-methyl-1-benzofuran-3-yl)acetic acid
分子名称: 2-(2-ethynyl-5-methyl-1-benzofuran-3-yl)ethanoic acid, IODIDE ION, Integrase, ...
著者Gorman, M.A, Parker, M.W.
登録日2020-03-02
公開日2021-03-03
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献HIV Integrase core domain in complex with inhibitor
To Be Published
6W42
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HIV Integrase core domain in complex with inhibitor 2-(5-methyl-2-(2-(thiophen-2-yl)ethynyl)-1-benzofuran-3-yl)acetic acid
分子名称: 2-[5-methyl-2-(2-thiophen-2-ylethynyl)-1-benzofuran-3-yl]ethanoic acid, HIV Integrase catalytic domain, IODIDE ION, ...
著者Gorman, M.A, Parker, M.W.
登録日2020-03-09
公開日2021-03-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献HIV Integrase core domain in complex with inhibitor (5-methyl-1-benzofuran-3-yl)acetic acid
To Be Published
5IMT
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BU of 5imt by Molmil
Toxin receptor complex
分子名称: CD59 glycoprotein, COPPER (II) ION, Intermedilysin, ...
著者Morton, C.J, Lawrence, S.L, Feil, S.C, Parker, M.W.
登録日2016-03-06
公開日2016-08-24
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.7001 Å)
主引用文献Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
5IMY
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BU of 5imy by Molmil
Trapped Toxin
分子名称: CD59 glycoprotein, Vaginolysin
著者Lawrence, S.L, Morton, C.J, Parker, M.W.
登録日2016-03-07
公開日2016-08-24
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
6WDR
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BU of 6wdr by Molmil
Subunit joining exposes nascent pre-40S rRNA for processing and quality control
分子名称: 20S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S10-A, ...
著者Rai, J, Parker, M.D, Huang, H, Choy, S, Ghalei, H, Johnson, M.C, Karbstein, K, Stroupe, M.E.
登録日2020-04-01
公開日2020-09-30
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7.
Rna, 27, 2021
6BFS
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BU of 6bfs by Molmil
The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies
分子名称: Fab Heavy Chain, Fab light Chain, Granulocyte-macrophage colony-stimulating factor
著者Dhagat, U, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W.
登録日2017-10-26
公開日2018-09-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
6U76
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BU of 6u76 by Molmil
Structure of methanesulfinate monooxygenase MsuC from Pseudomonas fluorescens.
分子名称: methanesulfinate monooxygenase
著者Soule, J, Gnann, A.D, Parker, M.J, McKenna, K.C, Nguyen, S.V, Phan, N.T, Wicht, D.K, Dowling, D.P.
登録日2019-08-31
公開日2020-11-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献To be published
To Be Published
6UUG
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BU of 6uug by Molmil
Structure of methanesulfinate monooxygenase MsuC from Pseudomonas fluorescens at 1.69 angstrom resolution
分子名称: Putative dehydrogenase
著者Soule, J, Gnann, A.D, Gonzalez, R, Parker, M.J, McKenna, K.C, Nguyen, S.V, Phan, N.T, Wicht, D.K, Dowling, D.P.
登録日2019-10-30
公開日2019-12-04
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.685 Å)
主引用文献Structure and function of the two-component flavin-dependent methanesulfinate monooxygenase within bacterial sulfur assimilation.
Biochem.Biophys.Res.Commun., 522, 2020
4TKX
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BU of 4tkx by Molmil
Structure of Protease
分子名称: 1,2-ETHANEDIOL, ACETATE ION, LEAD (II) ION, ...
著者Gorman, M.A, Parker, M.W.
登録日2014-05-28
公開日2014-12-31
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health.
Protein Sci., 24, 2015
4RS1
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BU of 4rs1 by Molmil
Crystal structure of receptor-cytokine complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Granulocyte-macrophage colony-stimulating factor, ...
著者Broughton, S.E, Parker, M.W, Dhagat, U.
登録日2014-11-06
公開日2015-11-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
7M5Z
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BU of 7m5z by Molmil
Crystal Structure of the MerTK Kinase Domain in Complex with Inhibitor MIPS15692
分子名称: 2-(butylamino)-N-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide, Tyrosine-protein kinase Mer
著者Hermans, S.J, Hancock, N.C, Baell, J.B, Parker, M.W.
登録日2021-03-25
公開日2021-10-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Development of [ 18 F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease.
Eur.J.Med.Chem., 226, 2021
10GS
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BU of 10gs by Molmil
HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH TER117
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE P1-1, L-gamma-glutamyl-S-benzyl-N-[(S)-carboxy(phenyl)methyl]-L-cysteinamide
著者Oakley, A, Parker, M.
登録日1997-08-14
公開日1998-09-16
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
2GSS
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BU of 2gss by Molmil
HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ETHACRYNIC ACID, GLUTATHIONE S-TRANSFERASE P1-1, ...
著者Oakley, A.J, Rossjohn, J, Parker, M.W.
登録日1996-10-29
公開日1997-11-12
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.
Biochemistry, 36, 1997
7L1P
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BU of 7l1p by Molmil
HIV Integrase Core domain (IN) in complex with dimer-spanning ligand
分子名称: (2-{[3-(4-{2-[(3-{[3-(carboxymethyl)-5-methyl-1-benzofuran-2-yl]ethynyl}benzene-1-carbonyl)amino]ethyl}piperazine-1-carbonyl)phenyl]ethynyl}-5-methyl-1-benzofuran-3-yl)acetic acid, IODIDE ION, Integrase, ...
著者Gorman, M.A, Parker, M.W.
登録日2020-12-15
公開日2021-12-22
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献HIV Integrase core domain in complex with inhibitor
To Be Published
7L2Y
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BU of 7l2y by Molmil
HIV Integrase core domain in complex with inhibitor 2-(5-(3-fluorophenyl)-2-(2-(thiophen-2-yl)ethynyl)-1- benzofuran-3-yl)ethanoic acid
分子名称: 4-{[3-(carboxymethyl)-5-methyl-1-benzofuran-2-yl]ethynyl}benzoic acid, IODIDE ION, Integrase, ...
著者Gorman, M.A, Parker, M.W.
登録日2020-12-17
公開日2021-12-22
実験手法X-RAY DIFFRACTION (1.982 Å)
主引用文献HIV Integrase core domain in complex with inhibitor
To Be Published
7LO4
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BU of 7lo4 by Molmil
SARS-CoV-2 spike receptor-binding domain with a G485R mutation in complex with human ACE2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Weekley, C.M, Parker, M.W.
登録日2021-02-09
公開日2021-03-31
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.465 Å)
主引用文献SARS-CoV-2 Spike receptor-binding domain with a G485R mutation in complex with human ACE2
Biorxiv, 2021
7LQP
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BU of 7lqp by Molmil
Rapid development of potent inhibitors of the HIV integrase-LEDGF interaction by fragment-linking using off-rate screening
分子名称: 2-[2-[2-[3-[2-[2-[2-[[3-[2-[3-(2-hydroxy-2-oxoethyl)-5-methyl-1-benzofuran-2-yl]ethynyl]phenyl]carbonylamino]ethoxy]ethoxy]ethylcarbamoyl]phenyl]ethynyl]-5-methyl-1-benzofuran-3-yl]ethanoic acid, IODIDE ION, Integrase, ...
著者Gorman, M.A, Parker, M.W.
登録日2021-02-15
公開日2022-02-23
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Rapid development of potent inhibitors of the HIV integrase-LEDGF interaction by fragment-linking using off-rate screening
To Be Published
2R4V
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BU of 2r4v by Molmil
Structure of human CLIC2, crystal form A
分子名称: Chloride intracellular channel protein 2, GLUTATHIONE
著者Hansen, G, Cromer, B.A, Gorman, M.A, Parker, M.W.
登録日2007-09-02
公開日2007-11-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of the Janus Protein Human CLIC2
J.Mol.Biol., 374, 2007
2R5G
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BU of 2r5g by Molmil
Structure of human CLIC2, crystal form B
分子名称: Chloride intracellular channel protein 2
著者Gorman, M.A, Hansen, G, Cromer, B.A, Parker, M.W.
登録日2007-09-03
公開日2007-11-13
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure of the Janus Protein Human CLIC2
J.Mol.Biol., 374, 2007

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件を2024-11-06に公開中

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