7LQP

Rapid development of potent inhibitors of the HIV integrase-LEDGF interaction by fragment-linking using off-rate screening

Summary for 7LQP

• Entry DOI: 10.2210/pdb7lqp/pdb
• Related: 6W42
• Descriptor: Integrase, IODIDE ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: inhibitor, hiv integrase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Human immunodeficiency virus 1 (HIV-1)
• Total number of polymer chains: 2
• Total formula weight: 38409.58

Authors

Gorman, M.A.,Parker, M.W. (deposition date: 2021-02-15, release date: 2022-02-23)

• Primary citation: Gorman, M.A.,Parker, M.W.; Rapid development of potent inhibitors of the HIV integrase-LEDGF interaction by fragment-linking using off-rate screening; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.07 Å)