5TUL
 
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5TUF
 | | Crystal structure of tetracycline destructase Tet(50) in complex with anhydrotetracycline | | 分子名称: | 5A,6-ANHYDROTETRACYCLINE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... | | 著者 | Park, J, Tolia, N.H. | | 登録日 | 2016-11-06 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
Nat. Chem. Biol., 13, 2017
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4NFJ
 | | Crystal structure of human FPPS in complex with magnesium, JDS05120, and sulfate | | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Park, J, De Schutter, J.W, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-10-31 | | 公開日 | 2014-12-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
PLoS ONE, 12, 2017
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4NFI
 | | Crystal structure of human FPPS in complex with magnesium and JDS05120 | | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, [({5-[4-(cyclopropyloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid) | | 著者 | Park, J, De Schutter, J.W, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-10-31 | | 公開日 | 2014-12-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
PLoS ONE, 12, 2017
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4NFK
 | | Crystal structure of human FPPS in complex with nickel, JDS05120, and sulfate | | 分子名称: | Farnesyl pyrophosphate synthase, NICKEL (II) ION, SULFATE ION, ... | | 著者 | Park, J, De schutter, J.W, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2013-10-31 | | 公開日 | 2014-12-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.
PLoS ONE, 12, 2017
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7XQW
 | | Formate dehydrogenase (FDH) from Methylobacterium extorquens AM1 (MeFDH1) | | 分子名称: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | | 著者 | Park, J, Heo, Y.Y, Roh, S.H, Lee, H.H. | | 登録日 | 2022-05-09 | | 公開日 | 2023-08-09 | | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | | 主引用文献 | Enzymatic conversion of CO2 in real flue gas to molar-scale formate
To Be Published
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4QY6
 | | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations | | 分子名称: | Beta-lactamase TEM, Beta-lactamase PSE-4, CHLORIDE ION, ... | | 著者 | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | | 登録日 | 2014-07-23 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations
To be Published
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4QXS
 | | Crystal structure of human FPPS in complex with WC01088 | | 分子名称: | (2-{2-[(2S)-3-methylbutan-2-yl]-5-phenyl-1H-indol-3-yl}ethane-1,1-diyl)bis(phosphonic acid), Farnesyl pyrophosphate synthase, GLYCEROL, ... | | 著者 | Park, J, Zielinski, M, Weiling, C, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2014-07-21 | | 公開日 | 2015-02-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase.
Bioorg.Med.Chem.Lett., 25, 2015
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4QY5
 | | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations | | 分子名称: | Beta-lactamase TEM,Beta-lactamase PSE-4, CHLORIDE ION, MAGNESIUM ION | | 著者 | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | | 登録日 | 2014-07-23 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | | 主引用文献 | Crystal structures of chimeric beta-lactamase cTEM-19m showing different conformations
To be Published
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6C57
 | | Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with bisphosphonate inhibitor FV0109 | | 分子名称: | Geranylgeranyl pyrophosphate synthase, {[(2-{3-[(4-fluorobenzene-1-carbonyl)amino]phenyl}thieno[2,3-d]pyrimidin-4-yl)amino]methylene}bis(phosphonic acid) | | 著者 | Park, J, Bin, X, Vincent, F, Tsantrizos, Y.S, Berghuis, A.M. | | 登録日 | 2018-01-15 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
J. Med. Chem., 61, 2018
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6K17
 | | Crystal structure of EXD2 exonuclease domain | | 分子名称: | Exonuclease 3'-5' domain-containing protein 2, SODIUM ION | | 著者 | Park, J, Lee, C. | | 登録日 | 2019-05-10 | | 公開日 | 2019-05-22 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic Acids Res., 47, 2019
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6K1E
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6K1B
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6N82
 | | Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Farnesyl pyrophosphate synthase, ... | | 著者 | Park, J, Schilling, M.A, Berghuis, A.M. | | 登録日 | 2018-11-28 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
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6N9H
 | | De novo designed homo-trimeric amantadine-binding protein | | 分子名称: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, SODIUM ION, amantadine-binding protein | | 著者 | Park, J, Baker, D. | | 登録日 | 2018-12-03 | | 公開日 | 2019-12-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.039 Å) | | 主引用文献 | De novo design of a homo-trimeric amantadine-binding protein.
Elife, 8, 2019
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6N7Y
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6N83
 | | Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037 | | 分子名称: | CHLORIDE ION, Farnesyl pyrophosphate synthase, PHOSPHATE ION, ... | | 著者 | Park, J, Schilling, M.A, Berghuis, A.M. | | 登録日 | 2018-11-28 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
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6N7Z
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6OAH
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6OAG
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7CZ3
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5XHW
 | | Crystal structure of HddC from Yersinia pseudotuberculosis | | 分子名称: | Putative 6-deoxy-D-mannoheptose pathway protein, SULFATE ION | | 著者 | Park, J, Kim, H, Kim, S, Shin, D.H. | | 登録日 | 2017-04-24 | | 公開日 | 2018-04-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of d-glycero-alpha-d-manno-heptose-1-phosphate guanylyltransferase from Yersinia pseudotuberculosis.
Biochim. Biophys. Acta, 1866, 2018
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5X9Q
 | | Crystal structure of HldC from Burkholderia pseudomallei | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Putative cytidylyltransferase | | 著者 | Park, J, Kim, H, Kim, S, Lee, D, Shin, D.H. | | 登録日 | 2017-03-08 | | 公開日 | 2017-12-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of D-glycero-Beta-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei.
Proteins, 86, 2018
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5XF2
 | | Crystal structure of SeMet-HldC from Burkholderia pseudomallei | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Putative cytidylyltransferase | | 著者 | Park, J, Kim, H, Kim, S, Lee, D, Shin, D.H. | | 登録日 | 2017-04-07 | | 公開日 | 2017-07-19 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Expression and crystallographic studies of D-glycero-beta-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei
Acta Crystallogr F Struct Biol Commun, 73, 2017
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5XHP
 | | Transferase with ligands | | 分子名称: | ARGININE, MANGANESE (II) ION, Putative cytoplasmic protein, ... | | 著者 | Park, J, Yoo, Y, Kim, Y.H, Cho, H.S. | | 登録日 | 2017-04-22 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of L-arginine and UDP bounded glycosyltransfease
To Be Published
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