8RQG
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5NJ3
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![BU of 5nj3 by Molmil](/molmil-images/mine/5nj3) | Structure of an ABC transporter: complete structure | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... | Authors: | Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P. | Deposit date: | 2017-03-28 | Release date: | 2017-06-07 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Structure of the human multidrug transporter ABCG2. Nature, 546, 2017
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5U0S
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![BU of 5u0s by Molmil](/molmil-images/mine/5u0s) | Cryo-EM structure of the Mediator-RNAPII complex | Descriptor: | Mediator complex subunit 10, Mediator complex subunit 11, Mediator complex subunit 14, ... | Authors: | Tsai, K.-L, Yu, X, Gopalan, S, Chao, T.-C, Zhang, Y, Florens, L, Washburn, M.P, Murakami, K, Conaway, R.C, Conaway, J.W, Asturias, F. | Deposit date: | 2016-11-26 | Release date: | 2017-03-08 | Last modified: | 2020-01-01 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | Mediator structure and rearrangements required for holoenzyme formation. Nature, 544, 2017
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1H7V
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![BU of 1h7v by Molmil](/molmil-images/mine/1h7v) | Rubredoxin from Guillardia Theta | Descriptor: | RUBREDOXIN, ZINC ION | Authors: | Schweimer, K, Hoffmann, S, Wastl, J, Maier, U.G, Roesch, P, Sticht, H. | Deposit date: | 2001-01-16 | Release date: | 2002-01-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of a zinc substituted eukaryotic rubredoxin from the cryptomonad alga Guillardia theta. Protein Sci., 9, 2000
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5EE7
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![BU of 5ee7 by Molmil](/molmil-images/mine/5ee7) | Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893 | Descriptor: | 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid, Glucagon receptor,Endolysin,Glucagon receptor, ... | Authors: | Jazayeri, A, Dore, A.S, Lamb, D, Krishnamurthy, H, Southall, S.M, Baig, A.H, Bortolato, A, Koglin, M, Robertson, N.J, Errey, J.C, Andrews, S.P, Brown, A.J.H, Cooke, R.M, Weir, M, Marshall, F.H. | Deposit date: | 2015-10-22 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Extra-helical binding site of a glucagon receptor antagonist. Nature, 533, 2016
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2PIT
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![BU of 2pit by Molmil](/molmil-images/mine/2pit) | Androgen receptor LBD with small molecule | Descriptor: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, SULFATE ION, ... | Authors: | Estebanez-Perpina, E, Arnold, A.A, Baxter, J.D, Webb, P, Guy, R.K, Fletterick, K.R. | Deposit date: | 2007-04-13 | Release date: | 2007-09-25 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | A surface on the androgen receptor that allosterically regulates coactivator binding. Proc.Natl.Acad.Sci.Usa, 104, 2007
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3ZIM
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![BU of 3zim by Molmil](/molmil-images/mine/3zim) | Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha | Descriptor: | 1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methyl-hept-5-ene-1,4- dione, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM | Authors: | Nacht, M, Qiao, L, Sheets, M.P, Martin, T.S, Labenski, M, Mazdiyasni, H, Karp, R, Zhu, Z, Chaturvedi, P, Bhavsar, D, Niu, D, Westlin, W, Petter, R.C, Medikonda, A.P, Jestel, A, Blaesse, M, Singh, J. | Deposit date: | 2013-01-09 | Release date: | 2013-02-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase Pi3Kalpha J.Med.Chem., 56, 2013
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7UFO
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7KMO
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6NKA
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8RH2
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![BU of 8rh2 by Molmil](/molmil-images/mine/8rh2) | Trimeric HSV-2G gB ectodomain in postfusion conformation with three bound HDIT102 Fab molecules. | Descriptor: | Envelope glycoprotein B, HDIT102 Fab heavy chain, HDIT102 Fab light chain | Authors: | Kalbermatter, D, Seyfizadeh, N, Imhof, T, Ries, M, Mueller, C, Jenner, L, Blumenschein, E, Yendrzheyevskiy, A, Moog, K, Eckert, D, Engel, R, Diebolder, P, Chami, M, Krauss, J, Schaller, T, Arndt, M. | Deposit date: | 2023-12-14 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus. J.Biomed.Sci., 31, 2024
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5MO8
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![BU of 5mo8 by Molmil](/molmil-images/mine/5mo8) | Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound | Descriptor: | 3-[[3-[3-[(3-chloranyl-4-phenyl-phenyl)methylamino]propylamino]-3-oxidanylidene-propanoyl]amino]benzoic acid, ACETATE ION, Casein kinase II subunit alpha, ... | Authors: | Brear, P, De Fusco, C, Georgiou, K, Iegre, J, Sore, H, Hyvonen, M, Spring, D. | Deposit date: | 2016-12-13 | Release date: | 2017-05-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorg. Med. Chem., 25, 2017
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2WD7
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![BU of 2wd7 by Molmil](/molmil-images/mine/2wd7) | PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00066750 | Descriptor: | 6-chloro-1H-benzimidazol-2-amine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PTERIDINE REDUCTASE | Authors: | Robinson, D.A, Wyatt, P.G, Spinks, D, Brenk, R. | Deposit date: | 2009-03-20 | Release date: | 2009-06-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening. J.Med.Chem., 52, 2009
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4ETO
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![BU of 4eto by Molmil](/molmil-images/mine/4eto) | Structure of S100A4 in complex with non-muscle myosin-IIA peptide | Descriptor: | CALCIUM ION, Myosin-9, Protein S100-A4 | Authors: | Ramagopal, U.A, Dulyaninova, N.G, Kumar, P.R, Almo, S.C, Bresnick, A.R, New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN) | Deposit date: | 2012-04-24 | Release date: | 2012-07-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Structure of S100A4 with bound peptide P To be Published
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1YIJ
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![BU of 1yij by Molmil](/molmil-images/mine/1yij) | Crystal Structure Of Telithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui | Descriptor: | 23S Ribosomal RNA, 50S RIBOSOMAL PROTEIN L10E, 50S RIBOSOMAL PROTEIN L11P, ... | Authors: | Tu, D, Blaha, G, Moore, P.B, Steitz, T.A. | Deposit date: | 2005-01-12 | Release date: | 2005-04-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell(Cambridge,Mass.), 121, 2005
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8V2O
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![BU of 8v2o by Molmil](/molmil-images/mine/8v2o) | Cryo-EM Structure of Wildtype Smooth Muscle Gamma Actin (ACTG2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, gamma-enteric smooth muscle, ... | Authors: | Palmer, N.J, Carman, P.J, Ceron, R.H, Dominguez, R. | Deposit date: | 2023-11-23 | Release date: | 2024-05-01 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Molecular mechanisms linking missense ACTG2 mutations to visceral myopathy. Sci Adv, 10, 2024
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8QTA
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8QT6
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8QT9
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![BU of 8qt9 by Molmil](/molmil-images/mine/8qt9) | Cryo-EM structure of stably reduced Streptococcus pneumoniae NADPH oxidase in complex with NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FAD-binding FR-type domain-containing protein, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Dubach, V.R.A, San Segundo-Acosta, P, Murphy, B.J. | Deposit date: | 2023-10-12 | Release date: | 2024-07-24 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (2.36 Å) | Cite: | Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase. Nat.Struct.Mol.Biol., 2024
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2WE0
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![BU of 2we0 by Molmil](/molmil-images/mine/2we0) | EBV dUTPase mutant Cys4Ser | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE, MALATE LIKE INTERMEDIATE, ... | Authors: | Freeman, L, Buisson, M, Tarbouriech, N, Burmeister, W.P. | Deposit date: | 2009-03-27 | Release date: | 2009-07-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | The Flexible Motif V of Epstein-Barr Virus Deoxyuridine 5'-Triphosphate Pyrophosphatase is Essential for Catalysis. J.Biol.Chem., 284, 2009
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8QT7
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2W89
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![BU of 2w89 by Molmil](/molmil-images/mine/2w89) | Crystal structure of the E.coli tRNAArg aminoacyl stem issoacceptor RR-1660 at 2.0 Angstroem resolution | Descriptor: | 5'-R(*CP*GP*GP*AP*UP*GP*CP)-3', 5'-R(*GP*CP*AP*UP*CP*CP*GP)-3', GLYCEROL | Authors: | Eichert, A, Schreiber, A, Fuerste, J.P, Perbandt, M, Betzel, C, Erdmann, V.A, Foerster, C. | Deposit date: | 2009-01-15 | Release date: | 2009-11-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of the E. Coli tRNA(Arg) Aminoacyl Stem Isoacceptor Rr-1660 at 2.0 A Resolution. Biochem.Biophys.Res.Commun., 385, 2009
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8VI3
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![BU of 8vi3 by Molmil](/molmil-images/mine/8vi3) | TehA from Haemophilus influenzae purified in GDN | Descriptor: | Tellurite resistance protein TehA homolog | Authors: | Catalano, C, Senko, S, Tran, N.L, Lucier, K.W, Farwell, A.C, Silva, M.S, Dip, P.V, Poweleit, N, Scapin, G. | Deposit date: | 2024-01-03 | Release date: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | High-Resolution Cryo-Electron Microscopy Structure Determination of Haemophilus influenzae Tellurite-Resistance Protein A via 200 kV Transmission Electron Microscopy. Int J Mol Sci, 25, 2024
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3SGK
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![BU of 3sgk by Molmil](/molmil-images/mine/3sgk) | Unique carbohydrate/carbohydrate interactions are required for high affinity binding of FcgIII and antibodies lacking core fucose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)][2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fc fragment, ... | Authors: | Ferrara, C, Grau, S, Jaeger, C, Sondermann, P, Bruenker, P, Waldhauer, I, Hennig, M, Ruf, A, Rufer, A.C, Stihle, M, Umana, P, Benz, J. | Deposit date: | 2011-06-15 | Release date: | 2011-08-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose. Proc.Natl.Acad.Sci.USA, 108, 2011
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1YLU
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![BU of 1ylu by Molmil](/molmil-images/mine/1ylu) | The structure of E. coli nitroreductase with bound acetate, crystal form 2 | Descriptor: | ACETATE ION, FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase | Authors: | Race, P.R, Lovering, A.L, Green, R.M, Ossor, A, White, S.A, Searle, P.F, Wrighton, C.J, Hyde, E.I. | Deposit date: | 2005-01-19 | Release date: | 2005-02-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme. J.Biol.Chem., 280, 2005
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