2V4Y
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![BU of 2v4y by Molmil](/molmil-images/mine/2v4y) | THE STRUCTURE OF E. COLI UMP KINASE IN COMPLEX WITH ITS ALLOSTERIC REGULATOR GTP | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, URIDYLATE KINASE | Authors: | Meyer, P, Evrin, C, Briozzo, P, Joly, N, Barzu, O, Gilles, A.M. | Deposit date: | 2008-09-30 | Release date: | 2008-10-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and Functional Characterization of Escherichia Coli Ump Kinase in Complex with its Allosteric Regulator GTP. J.Biol.Chem., 283, 2008
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1N9V
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![BU of 1n9v by Molmil](/molmil-images/mine/1n9v) | Differences and Similarities in Solution Structures of Angiotensin I & II: Implication for Structure-Function Relationship. | Descriptor: | Angiotensin II | Authors: | Spyroulias, G.A, Nikolakopoulou, P, Tzakos, A, Gerothanassis, I.P, Magafa, V, Manessi-Zoupa, E, Cordopatis, P. | Deposit date: | 2002-11-26 | Release date: | 2003-07-29 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship. Eur.J.Biochem., 270, 2003
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5F8H
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![BU of 5f8h by Molmil](/molmil-images/mine/5f8h) | Enterovirus 71 Polymerase Elongation Complex (C1S1/2 Form) | Descriptor: | Genome polyprotein, MAGNESIUM ION, RNA (35-MER), ... | Authors: | Shu, B, Gong, P. | Deposit date: | 2015-12-09 | Release date: | 2016-06-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation Proc.Natl.Acad.Sci.USA, 113, 2016
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6PTA
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![BU of 6pta by Molmil](/molmil-images/mine/6pta) | Crystal structure of the ARF family small GTPase ARF1 from Candida albicans in complex with GDP | Descriptor: | ADP-ribosylation factor, GUANOSINE-5'-DIPHOSPHATE | Authors: | Stogios, P.J, Evdokimova, E, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2019-07-15 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the ARF family small GTPase ARF1 from Candida albicans in complex with GDP To Be Published
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1G9M
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![BU of 1g9m by Molmil](/molmil-images/mine/1g9m) | HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY 17B, HEAVY CHAIN, ... | Authors: | Kwong, P.D, Wyatt, R, Majeed, S, Robinson, J, Sweet, R.W, Sodroski, J, Hendrickson, W.A. | Deposit date: | 2000-11-24 | Release date: | 2000-12-27 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. Structure Fold.Des., 8, 2000
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5AJA
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![BU of 5aja by Molmil](/molmil-images/mine/5aja) | Crystal structure of mandrill SAMHD1 (amino acid residues 1-114) bound to Vpx isolated from mandrill and human DCAF1 (amino acid residues 1058-1396) | Descriptor: | PROTEIN VPRBP, SAM DOMAIN AND HD DOMAIN-CONTAINING PROTEIN, VPX PROTEIN, ... | Authors: | Schwefel, D, Boucherit, V.C, Christodoulou, E, Walker, P.A, Stoye, J.P, Bishop, K.N, Taylor, I.A. | Deposit date: | 2015-02-20 | Release date: | 2015-04-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.649 Å) | Cite: | Molecular Determinants for Recognition of Divergent Samhd1 Proteins by the Lentiviral Accessory Protein Vpx. Cell Host Microbe., 17, 2015
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7C9C
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![BU of 7c9c by Molmil](/molmil-images/mine/7c9c) | Human DMC1 pre-synaptic complexes | Descriptor: | CALCIUM ION, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Meiotic recombination protein DMC1/LIM15 homolog, ... | Authors: | Luo, S.C, Yeh, H.Y, Chi, P, Ho, M.C, Tsai, M.D. | Deposit date: | 2020-06-05 | Release date: | 2020-11-25 | Last modified: | 2021-01-27 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures. Nat Commun, 12, 2021
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8BXK
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![BU of 8bxk by Molmil](/molmil-images/mine/8bxk) | Ntaya virus methyltransferase | Descriptor: | Ntaya virus methyltransferase, SINEFUNGIN | Authors: | Boura, E, Krafcikova, P. | Deposit date: | 2022-12-09 | Release date: | 2023-01-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Ntaya virus methyltransferase To Be Published
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6X2A
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![BU of 6x2a by Molmil](/molmil-images/mine/6x2a) | |
6BQG
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![BU of 6bqg by Molmil](/molmil-images/mine/6bqg) | Crystal structure of 5-HT2C in complex with ergotamine | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine | Authors: | Peng, Y, McCorvy, J.D, Harpsoe, K, Lansu, K, Yuan, S, Popov, P, Qu, L, Pu, M, Che, T, Nikolajse, L.F, Huang, X.P, Wu, Y, Shen, L, Bjorn-Yoshimoto, W.E, Ding, K, Wacker, D, Han, G.W, Cheng, J, Katritch, V, Jensen, A.A, Hanson, M.A, Zhao, S, Gloriam, D.E, Roth, B.L, Stevens, R.C, Liu, Z. | Deposit date: | 2017-11-27 | Release date: | 2018-02-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. Cell, 172, 2018
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6WII
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![BU of 6wii by Molmil](/molmil-images/mine/6wii) | Crystal structure of the K. pneumoniae LpxH/JH-LPH-41 complex | Descriptor: | 5-({[4-({4-[3-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)phenyl]carbamoyl}amino)-N-hydroxypentanamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Cochrane, C.S, Cho, J, Fenton, B.A, Zhou, P. | Deposit date: | 2020-04-09 | Release date: | 2020-07-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors. Bioorg.Chem., 102, 2020
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1BLS
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![BU of 1bls by Molmil](/molmil-images/mine/1bls) | |
6ZHP
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![BU of 6zhp by Molmil](/molmil-images/mine/6zhp) | |
1BK0
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![BU of 1bk0 by Molmil](/molmil-images/mine/1bk0) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE COMPLEX) | Descriptor: | FE (III) ION, ISOPENICILLIN N SYNTHASE, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... | Authors: | Roach, P.L, Clifton, I.J, Hensgens, C.M.H, Shibata, N, Schofield, C.J, Hajdu, J, Baldwin, J.E. | Deposit date: | 1998-07-14 | Release date: | 1999-01-13 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature, 387, 1997
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7V1I
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![BU of 7v1i by Molmil](/molmil-images/mine/7v1i) | |
6PTY
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![BU of 6pty by Molmil](/molmil-images/mine/6pty) | Soluble model of human CuA (Tt3Lh) | Descriptor: | Cytochrome c oxidase subunit 2, DINUCLEAR COPPER ION, GLYCEROL, ... | Authors: | Giannini, E, Lisa, M.N, Morgada, M.N, Alzari, P.M, Vila, A.J. | Deposit date: | 2019-07-16 | Release date: | 2019-11-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Unexpected electron spin density on the axial methionine ligand in CuAsuggests its involvement in electron pathways. Chem.Commun.(Camb.), 56, 2020
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7K4X
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![BU of 7k4x by Molmil](/molmil-images/mine/7k4x) | Crystal structure of Kemp Eliminase HG3.7 in complex with the transition state analog 6-nitrobenzotriazole | Descriptor: | 6-NITROBENZOTRIAZOLE, ACETATE ION, Endo-1,4-beta-xylanase, ... | Authors: | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | Deposit date: | 2020-09-16 | Release date: | 2020-12-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7V1G
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6YYK
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![BU of 6yyk by Molmil](/molmil-images/mine/6yyk) | Crystal Structure of 1,5-dimethylindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C | Descriptor: | 1,5-dimethyl-3~{H}-indol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... | Authors: | Brear, P, Wagstaff, J, Hyvonen, M. | Deposit date: | 2020-05-05 | Release date: | 2021-05-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Optimising crystallographic systems for structure-guided drug discovery To Be Published
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7UPT
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![BU of 7upt by Molmil](/molmil-images/mine/7upt) | Human mitochondrial AAA protein ATAD1 (with a catalytic dead mutation) in complex with a peptide substrate (open conformation) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wang, L, Toutkoushian, H, Belyy, V, Kokontis, C, Walter, P. | Deposit date: | 2022-04-16 | Release date: | 2022-06-15 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. Elife, 11, 2022
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7C64
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![BU of 7c64 by Molmil](/molmil-images/mine/7c64) | Crystal structure of beta-glycosides-binding protein of ABC transporter in an open state (Form II) | Descriptor: | 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CARBON DIOXIDE, ... | Authors: | Kanaujia, S.P, Chandravanshi, M, Samanta, R. | Deposit date: | 2020-05-21 | Release date: | 2020-09-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Conformational Trapping of a beta-Glucosides-Binding Protein Unveils the Selective Two-Step Ligand-Binding Mechanism of ABC Importers. J.Mol.Biol., 432, 2020
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7V1E
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7C8G
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![BU of 7c8g by Molmil](/molmil-images/mine/7c8g) | Structure of alginate lyase AlyC3 | Descriptor: | Alginate lyase AlyC3, GLYCEROL, SUCCINIC ACID | Authors: | Zhang, Y.Z, Xu, F, Chen, X.L, Wang, P. | Deposit date: | 2020-05-30 | Release date: | 2020-10-07 | Last modified: | 2020-12-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and molecular basis for the substrate positioning mechanism of a new PL7 subfamily alginate lyase from the arctic. J.Biol.Chem., 295, 2020
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6YYF
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![BU of 6yyf by Molmil](/molmil-images/mine/6yyf) | Crystal Structure of 5-chloroindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C | Descriptor: | 5-chloranyl-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... | Authors: | Brear, P, Wagstaff, J, Hyvonen, M. | Deposit date: | 2020-05-05 | Release date: | 2021-05-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Optimising crystallographic systems for structure-guided drug discovery To Be Published
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6WT5
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![BU of 6wt5 by Molmil](/molmil-images/mine/6wt5) | Structure of a bacterial STING receptor from Capnocytophaga granulosa | Descriptor: | Bacterial STING | Authors: | Morehouse, B.R, Govande, A.A, Millman, A, Keszei, A.F.A, Lowey, B, Ofir, G, Shao, S, Sorek, R, Kranzusch, P.J. | Deposit date: | 2020-05-01 | Release date: | 2020-09-09 | Last modified: | 2020-10-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | STING cyclic dinucleotide sensing originated in bacteria. Nature, 586, 2020
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