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PDB: 45910 results

4KYY
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BU of 4kyy by Molmil
Crystal Structure of RNA 17-mer UUCGGUUUUGAUCCGGA duplex
Descriptor: POTASSIUM ION, RNA 17-mer
Authors:Smith, P.C, Shuman, S.
Deposit date:2013-05-29
Release date:2013-06-12
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of RNA 17-mer UUCGGUUUUGAUCCGGA duplex
To be Published
1O46
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BU of 1o46 by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395.
Descriptor: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-METHOXYCARBONYL-PHENYL}-2-FLUORO-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
6EUR
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BU of 6eur by Molmil
Crystal structure of the complex Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO5 with Fe(II)/alpha-ketoglutarate
Descriptor: 2-OXOGLUTARIC ACID, FE (III) ION, GLYCEROL, ...
Authors:Isabet, T, Stura, E, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-10-31
Release date:2018-11-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
2WFV
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BU of 2wfv by Molmil
Crystal structure of DILP5 variant C4
Descriptor: PROBABLE INSULIN-LIKE PEPTIDE 5 A CHAIN, PROBABLE INSULIN-LIKE PEPTIDE 5 B CHAIN
Authors:Kulahin, N, Schluckebier, G, Sajid, W, De Meyts, P.
Deposit date:2009-04-15
Release date:2010-05-26
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biological Properties of the Drosophila Insulin-Like Peptide 5 Show Evolutionary Conservation.
J.Biol.Chem., 286, 2011
5D2I
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BU of 5d2i by Molmil
4-oxalocrotonate decarboxylase from Pseudomonas putida G7 - complexed with calcium and acetate
Descriptor: 1,2-ETHANEDIOL, 4-oxalocrotonate decarboxylase NahK, ACETATE ION, ...
Authors:Guimaraes, S.L, Nagem, R.A.P.
Deposit date:2015-08-05
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal Structures of Apo and Liganded 4-Oxalocrotonate Decarboxylase Uncover a Structural Basis for the Metal-Assisted Decarboxylation of a Vinylogous beta-Keto Acid.
Biochemistry, 55, 2016
6SQY
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BU of 6sqy by Molmil
Mouse dCTPase in complex with dCMP
Descriptor: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, dCTP pyrophosphatase 1
Authors:Scaletti, E.R, Claesson, M, Helleday, H, Jemth, A.S, Stenmark, P.
Deposit date:2019-09-04
Release date:2020-01-29
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
J.Mol.Biol., 432, 2020
5T6M
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BU of 5t6m by Molmil
Structure of the tryptophan synthase b-subunit from Pyroccus furiosus with b-methyltryptophan non-covalently bound
Descriptor: (betaS)-beta-methyl-L-tryptophan, PHOSPHATE ION, SODIUM ION, ...
Authors:Buller, A.R, van Roye, P, Arnold, F.H.
Deposit date:2016-09-01
Release date:2016-12-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity.
Biochemistry, 55, 2016
5YHY
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BU of 5yhy by Molmil
Structure of Lactococcus lactis ZitR, C30S mutant
Descriptor: ZINC ION, Zinc transport transcriptional regulator
Authors:Song, Y, Liu, H, Zhu, R, Yi, C, Chen, P.
Deposit date:2017-10-01
Release date:2017-12-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation.
Proc.Natl.Acad.Sci.USA, 114, 2017
6Q0W
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BU of 6q0w by Molmil
Structure of DDB1-DDA1-DCAF15 complex bound to Indisulam and RBM39
Descriptor: DDB1- and CUL4-associated factor 15, DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, ...
Authors:Faust, T, Yoon, H, Nowak, R.P, Donovan, K.A, Li, Z, Cai, Q, Eleuteri, N.A, Zhang, T, Gray, N.S, Fischer, E.S.
Deposit date:2019-08-02
Release date:2019-11-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.
Nat.Chem.Biol., 16, 2020
2W2D
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BU of 2w2d by Molmil
Crystal Structure of a Catalytically Active, Non-toxic Endopeptidase Derivative of Clostridium botulinum Toxin A
Descriptor: ACETATE ION, BOTULINUM NEUROTOXIN A HEAVY CHAIN, BOTULINUM NEUROTOXIN A LIGHT CHAIN, ...
Authors:Masuyer, G, Thiyagarajan, N, James, P.L, Marks, P.M.H, Chaddock, J.A, Acharya, K.R.
Deposit date:2008-10-29
Release date:2009-03-24
Last modified:2022-05-04
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal Structure of a Catalytically Active, Non-Toxic Endopeptidase Derivative of Clostridium Botulinum Toxin A.
Biochem.Biophys.Res.Commun., 381, 2009
7AZE
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BU of 7aze by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 18 bound
Descriptor: Beta sliding clamp, GLYCEROL, MALONATE ION, ...
Authors:Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
Deposit date:2020-11-16
Release date:2021-12-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
6F1Z
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BU of 6f1z by Molmil
Roadblock-1 region of the dynein tail/dynactin/BICDR1 complex
Descriptor: Cytoplasmic dynein 1 intermediate chain 2, Dynein light chain roadblock-type 1
Authors:Urnavicius, L, Lau, C.K, Elshenawy, M.M, Morales-Rios, E, Motz, C, Yildiz, A, Carter, A.P.
Deposit date:2017-11-23
Release date:2018-01-17
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM shows how dynactin recruits two dyneins for faster movement.
Nature, 554, 2018
6SQW
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BU of 6sqw by Molmil
Mouse dCTPase in complex with 5-Me-dCMP
Descriptor: 5-METHYL-2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, dCTP pyrophosphatase 1
Authors:Scaletti, E.R, Claesson, M, Helleday, H, Jemth, A.S, Stenmark, P.
Deposit date:2019-09-04
Release date:2020-01-29
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
J.Mol.Biol., 432, 2020
8IYM
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BU of 8iym by Molmil
Crystal structure of a protein acetyltransferase, HP0935
Descriptor: 1,2-ETHANEDIOL, N-acetyltransferase domain-containing protein, POTASSIUM ION, ...
Authors:Dadireddy, V, Mahanta, P, Kumar, A, Desirazu, R.N, Ramakumar, S.
Deposit date:2023-04-05
Release date:2024-04-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a protein acetyltransferase, HP0935
To be published
4DUR
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BU of 4dur by Molmil
The X-ray Crystal Structure of Full-Length type II Human Plasminogen
Descriptor: ACETATE ION, BICARBONATE ION, CHLORIDE ION, ...
Authors:Law, R.H.P, Caradoc-Davies, T, Whisstock, J.C.
Deposit date:2012-02-22
Release date:2012-03-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The X-ray crystal structure of full-length human plasminogen
Cell Rep, 1, 2012
7EQU
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BU of 7equ by Molmil
Crystal structure of the C-lobe of lactoferrin produced by limited proteolysis using pepsin at 2.74A resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, FE (III) ION, ...
Authors:Maurya, A, Singh, J, Sharma, A, Sharma, P, Sharma, S, Singh, T.P.
Deposit date:2021-05-04
Release date:2021-05-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.743 Å)
Cite:Crystal structure of the C-lobe of lactoferrin produced by limited proteolysis using pepsin at 2.74A resolution
To Be Published
6Q4B
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BU of 6q4b by Molmil
CDK2 in complex with FragLite13
Descriptor: 5-bromanylpyrimidine, Cyclin-dependent kinase 2
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4J
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BU of 6q4j by Molmil
CDK2 in complex with FragLite34
Descriptor: 2-[3-(pyrimidin-4-ylamino)phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6F78
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BU of 6f78 by Molmil
Potent and selective Aldo-Keto Reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: Application of a Bioisosteric Scaffold Hopping Approach to Flufenamic acid
Descriptor: 4-[[3,5-bis(trifluoromethyl)phenyl]amino]-1,2-benzoxazol-3-one, Aldo-keto reductase family 1 member C3, CHLORIDE ION, ...
Authors:Goyal, P, Wahlgren, W.Y, Friemann, R.
Deposit date:2017-12-07
Release date:2018-04-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.
Eur J Med Chem, 150, 2018
4L1L
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BU of 4l1l by Molmil
Rat PKC C2 domain bound to CD
Descriptor: CADMIUM ION, Protein kinase C alpha type, SULFATE ION
Authors:Morales, K.M, Yang, Y, Long, Z, Li, P, Taylor, A.B, Hart, P.J, Igumenova, T.I.
Deposit date:2013-06-03
Release date:2013-08-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Cd(2+) as a ca(2+) surrogate in protein-membrane interactions: isostructural but not isofunctional.
J.Am.Chem.Soc., 135, 2013
6SZ1
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BU of 6sz1 by Molmil
Crystal structure of YTHDC1 with fragment 2 (DHU_DC1_140)
Descriptor: SULFATE ION, YTH domain-containing protein 1, ~{N}-methylquinazolin-4-amine
Authors:Bedi, R.K, Huang, D, Sledz, P, Caflisch, A.
Deposit date:2019-10-01
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments.
Acs Chem.Biol., 15, 2020
3O6Q
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BU of 3o6q by Molmil
The Structure of SpoIISA and SpoIISB, a Toxin - Antitoxin System
Descriptor: Stage II sporulation protein SA, Stage II sporulation protein SB
Authors:Levdikov, V.M, Blagova, E.V, Lebedev, A.A, Wilkinson, A.J, Florek, P, Barak, I.
Deposit date:2010-07-29
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure and interactions of SpoIISA and SpoIISB, a toxin-antitoxin system in Bacillus subtilis.
J.Biol.Chem., 161, 2010
7EVQ
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BU of 7evq by Molmil
Crystal structure of C-terminal half of lactoferrin obtained by limited proteolysis using pepsin at 2.6 A resolution
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, ...
Authors:Viswanathan, V, Singh, J, Sharma, P, Sharma, S, Singh, T.P.
Deposit date:2021-05-21
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of C-terminal half of lactoferrin obtained by limited proteolysis using pepsin at 2.6 A resolution
To Be Published
6PY1
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BU of 6py1 by Molmil
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, ACETATE ION, C-type lectin domain family 10 member A, ...
Authors:Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G.
Deposit date:2019-07-28
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Biochemistry, 60, 2021
6T05
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BU of 6t05 by Molmil
Crystal structure of YTHDC1 with fragment 18 (DHU_DC1_048)
Descriptor: 2-(phenylmethyl)imidazolidine, SULFATE ION, YTHDC1
Authors:Bedi, R.K, Huang, D, Sledz, P, Caflisch, A.
Deposit date:2019-10-02
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments.
Acs Chem.Biol., 15, 2020

223790

数据于2024-08-14公开中

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