6ZPK
| Crystal structure of the unconventional kinetochore protein Trypanosoma brucei KKT4 BRCT domain | Descriptor: | GLYCEROL, SULFATE ION, Trypanosoma brucei KKT4 463-645 | Authors: | Ludzia, P, Lowe, E.D, Marciano, G, Mohammed, S, Redfield, C, Akiyoshi, B. | Deposit date: | 2020-07-08 | Release date: | 2020-10-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein. Structure, 29, 2021
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4LFH
| Crystal Structure of 9C2 TCR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9C2 TCR delta chain, 9C2 TCR gamma chain, ... | Authors: | Uldrich, A.P, Le Nours, J, Pellicci, D.G, Gras, S, Rossjohn, J, Godfrey, D.I. | Deposit date: | 2013-06-26 | Release date: | 2013-10-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | CD1d-lipid antigen recognition by the gamma delta TCR. Nat.Immunol., 14, 2013
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4QPL
| Crystal structure of RNF146(RING-WWE)/UbcH5a/iso-ADPr complex | Descriptor: | 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate), E3 ubiquitin-protein ligase RNF146, Ubiquitin-conjugating enzyme E2 D1, ... | Authors: | Wang, Z, DaRosa, P.A, Klevit, R.E, Xu, W. | Deposit date: | 2014-06-23 | Release date: | 2014-10-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. Nature, 517, 2015
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1M8L
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1M8Z
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6ZO4
| The pointed end complex of dynactin bound to BICD2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ... | Authors: | Lau, C.K, Lacey, S.E, Carter, A.P. | Deposit date: | 2020-07-07 | Release date: | 2020-07-29 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (8.2 Å) | Cite: | Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end. Embo J., 40, 2021
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4L7B
| Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid | Descriptor: | (1S,2R)-2-{[(1S)-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid, ACETATE ION, Kelch-like ECH-associated protein 1, ... | Authors: | Jnoff, E, Brookfield, F, Albrecht, C, Barker, J.J, Barker, O, Beaumont, E, Bromidge, S, Brooks, M, Ceska, T, Courade, J.P, Crabbe, T, Duclos, S, Fryatt, T, Jigorel, E, Kwong, J, Sands, Z, Smith, M.A. | Deposit date: | 2013-06-13 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex. Chemmedchem, 9, 2014
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6VBT
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6BZP
| STGGYG from low-complexity domain of FUS, residues 77-82 | Descriptor: | 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, RNA-binding protein FUS | Authors: | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Gonen, T, Eisenberg, D.S. | Deposit date: | 2017-12-25 | Release date: | 2018-04-04 | Last modified: | 2024-03-13 | Method: | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | Cite: | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks. Science, 359, 2018
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4KV6
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6BZR
| Human ABCC6 NBD2 in ADP-bound state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CITRIC ACID, Multidrug resistance-associated protein 6 | Authors: | Zheng, A, Thibodeau, P.H. | Deposit date: | 2017-12-25 | Release date: | 2019-01-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.79999447 Å) | Cite: | Structures of human ABCC6 NBD1 and NBD2 To Be Published
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4QUL
| Caspase-3 F55W | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, Caspase-3 | Authors: | Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. | Deposit date: | 2014-07-10 | Release date: | 2014-11-05 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
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6M3S
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4KYS
| Clostridium botulinum thiaminase I in complex with thiamin | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, CITRIC ACID, MAGNESIUM ION, ... | Authors: | Sikowitz, M.D, Shome, B, Zhang, Y, Begley, T.P, Ealick, S.E. | Deposit date: | 2013-05-29 | Release date: | 2013-10-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structure of a Clostridium botulinum C143S Thiaminase I/Thiamin Complex Reveals Active Site Architecture. Biochemistry, 52, 2013
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7A4C
| Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine | Descriptor: | 5,6,7-tris(bromanyl)-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, Casein kinase II subunit alpha, GLYCEROL, ... | Authors: | Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. | Deposit date: | 2020-08-19 | Release date: | 2020-12-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021
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1M3K
| biosynthetic thiolase, inactive C89A mutant | Descriptor: | Acetyl-CoA acetyltransferase, GLYCEROL, SULFATE ION | Authors: | Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K. | Deposit date: | 2002-06-28 | Release date: | 2002-11-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The catalytic cycle of biosynthetic thiolase: A conformational
journey of an acetyl group through four binding modes and two oxyanion holes Biochemistry, 41, 2002
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4QU0
| Caspase-3 Y195AV266H | Descriptor: | ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, Caspase-3 | Authors: | Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. | Deposit date: | 2014-07-10 | Release date: | 2014-11-05 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.954 Å) | Cite: | Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
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4QUE
| Caspase-3 Y195FV266H | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, ... | Authors: | Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C. | Deposit date: | 2014-07-10 | Release date: | 2014-11-05 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.843 Å) | Cite: | Modifying caspase-3 activity by altering allosteric networks. Biochemistry, 53, 2014
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1MK0
| catalytic domain of intron endonuclease I-TevI, E75A mutant | Descriptor: | BETA-MERCAPTOETHANOL, CITRIC ACID, Intron-associated endonuclease 1 | Authors: | Van Roey, P, Meehan, L, Kowalski, J.C, Belfort, M, Derbyshire, V. | Deposit date: | 2002-08-28 | Release date: | 2002-10-30 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Catalytic domain structure and hypothesis for function of GIY-YIG intron endonuclease I-TevI. Nat.Struct.Biol., 9, 2002
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6M6Q
| Crystal structure of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3) N-terminal domain | Descriptor: | Dicer Related Helicase | Authors: | Li, K, Zheng, J, Wirawan, M, Xiong, Z, Fedorova, O, Griffin, P, Plyle, A, Luo, D. | Deposit date: | 2020-03-16 | Release date: | 2021-03-17 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3). Nucleic Acids Res., 49, 2021
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4L0M
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7PFS
| Crystal structure of ERAP2 aminopeptidase in complex with phosphinic pseudotripeptide ((1R)-1-Amino-3-phenylpropyl){2-([1,1:3,1-terphenyl]-5-ylmethyl)-3-[((2S)-1-amino-1-oxo-3-phenylpropan-2-yl)-amino]-3-oxopropyl}phosphinic acid | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Giastas, P, Stratikos, E, Mpakali, A. | Deposit date: | 2021-08-12 | Release date: | 2022-01-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Inhibitor-Dependent Usage of the S1' Specificity Pocket of ER Aminopeptidase 2. Acs Med.Chem.Lett., 13, 2022
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6VH6
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7PUF
| urate oxidase azaxanthine complex under 600 bar (60 MPa) of argon | Descriptor: | 8-AZAXANTHINE, ARGON, SODIUM ION, ... | Authors: | Prange, T, Colloc'h, N, Carpentier, P. | Deposit date: | 2021-09-29 | Release date: | 2022-02-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Comparative study of the effects of high hydrostatic pressure per se and high argon pressure on urate oxidase ligand stabilization Acta Cryst. D, 78, 2022
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3J27
| CryoEM structure of Dengue virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, ... | Authors: | Zhang, X, Ge, P, Yu, X, Brannan, J.M, Bi, G, Zhang, Q, Schein, S, Zhou, Z.H. | Deposit date: | 2012-09-26 | Release date: | 2012-12-19 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the mature dengue virus at 3.5-A resolution. Nat.Struct.Mol.Biol., 20, 2012
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