5QP1
 
 | | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z1190363272 | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DCP2 (NUDT20), ... | | 著者 | Nelson, E.R, Velupillai, S, Talon, R, Collins, P.M, Krojer, T, Wang, D, Brandao-Neto, J, Douangamath, A, Burgess-Brown, N, Arrowsmith, C.H, Bountra, C, Huber, K, von Delft, F. | | 登録日 | 2019-02-22 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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1TFE
 | | DIMERIZATION DOMAIN OF EF-TS FROM T. THERMOPHILUS | | 分子名称: | ELONGATION FACTOR TS | | 著者 | Jiang, Y, Nock, S, Nesper, M, Sprinzl, M, Sigler, P.B. | | 登録日 | 1996-04-16 | | 公開日 | 1996-11-08 | | 最終更新日 | 2018-03-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure and importance of the dimerization domain in elongation factor Ts from Thermus thermophilus.
Biochemistry, 35, 1996
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2HRS
 | | Crystal structure of L42H V224H design intermediate for GFP metal ion reporter | | 分子名称: | 1,2-ETHANEDIOL, Green fluorescent protein, MAGNESIUM ION | | 著者 | Barondeau, D.P, Tubbs, J.L, Tainer, J.A, Getzoff, E.D. | | 登録日 | 2006-07-20 | | 公開日 | 2008-04-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Iterative Structure-Based Design of a Green Fluorescent Protein Metal Ion Reporter
To be Published
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5QR2
 | | PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z1348371854 | | 分子名称: | 5-(1,4-oxazepan-4-yl)pyridine-2-carbonitrile, 5-aminolevulinate synthase, erythroid-specific, ... | | 著者 | Bezerra, G.A, Foster, W, Bailey, H, Shrestha, L, Krojer, T, Talon, R, Brandao-Neto, J, Douangamath, A, Nicola, B.B, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Brennan, P.E, Yue, W.W. | | 登録日 | 2019-05-22 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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7S9Z
 | | Helicobacter Hepaticus CcsBA Closed Conformation | | 分子名称: | Cytochrome c biogenesis protein, HEME B/C, PHOSPHATIDYLETHANOLAMINE | | 著者 | Mendez, D.L, Lowder, E.P, Tillman, D.E, Sutherland, M.C, Collier, A.L, Rau, M.J, Fitzpatrick, J.A, Kranz, R.G. | | 登録日 | 2021-09-21 | | 公開日 | 2021-12-22 | | 最終更新日 | 2022-01-12 | | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | | 主引用文献 | Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport.
Nat.Chem.Biol., 18, 2022
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3H7P
 | | Crystal structure of K63-linked di-ubiquitin | | 分子名称: | CADMIUM ION, Ubiquitin | | 著者 | Weeks, S.D, Grasty, K.C, Hernandez-Cuebas, L, Loll, P.J. | | 登録日 | 2009-04-28 | | 公開日 | 2009-09-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structures of Lys-63-linked tri- and di-ubiquitin reveal a highly extended chain architecture.
Proteins, 77, 2009
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5UXC
 | | Crystal structure of macrolide 2'-phosphotransferase MphH from Brachybacterium faecium in complex with GDP | | 分子名称: | AZITHROMYCIN, CHLORIDE ION, GLYCEROL, ... | | 著者 | Stogios, P.J, Skarina, T, Wawrzak, Z, Yim, V, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2017-02-22 | | 公開日 | 2017-08-16 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.
Nat Commun, 9, 2018
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8C7X
 | | Crystal structure of BRAF in complex with a hybrid compound 6 | | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, Serine/threonine-protein kinase B-raf, ... | | 著者 | Chaikuad, A, Bonnet, P, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2023-01-17 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor.
Eur.J.Med.Chem., 250, 2023
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3GL2
 | | Crystal structure of dicamba monooxygenase bound to dicamba | | 分子名称: | 3,6-dichloro-2-methoxybenzoic acid, DdmC, FE (III) ION, ... | | 著者 | Wilson, M.A, Dumitru, R, Jiang, W.Z, Weeks, D.P. | | 登録日 | 2009-03-11 | | 公開日 | 2009-08-04 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of dicamba monooxygenase: a Rieske nonheme oxygenase that catalyzes oxidative demethylation.
J.Mol.Biol., 392, 2009
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7S9Y
 | | Helicobacter Hepaticus CcsBA Open Conformation | | 分子名称: | Cytochrome c biogenesis protein, HEME B/C, PHOSPHATIDYLETHANOLAMINE | | 著者 | Mendez, D.L, Lowder, E.P, Tillman, D.E, Sutherland, M.C, Collier, A.L, Rau, M.J, Fitzpatrick, J.A, Kranz, R.G. | | 登録日 | 2021-09-21 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport.
Nat.Chem.Biol., 18, 2022
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2HUC
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8C7Y
 | | Crystal structure of BRAF V600E in complex with a hybrid compound 6 | | 分子名称: | 1,2-ETHANEDIOL, NITRATE ION, Serine/threonine-protein kinase B-raf, ... | | 著者 | Chaikuad, A, Bonnet, P, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2023-01-17 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor.
Eur.J.Med.Chem., 250, 2023
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4ER0
 | | Crystal Structure of human DOT1L in complex with inhibitor FED1 | | 分子名称: | 5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5'-deoxyadenosine, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... | | 著者 | Wernimont, A.K, Tempel, W, Yu, W, Li, Y, Nguyen, K.T, Federation, A, Marineau, J, Qi, J, Vedadi, M, Bradner, J.E, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2012-04-19 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun, 3, 2012
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5QOJ
 | | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with FMOCR000171b | | 分子名称: | 1,2-ETHANEDIOL, 2-(thiophen-2-yl)-1H-imidazole, ACETATE ION, ... | | 著者 | Nelson, E.R, Velupillai, S, Talon, R, Collins, P.M, Krojer, T, Wang, D, Brandao-Neto, J, Douangamath, A, Burgess-Brown, N, Arrowsmith, C.H, Bountra, C, Huber, K, von Delft, F. | | 登録日 | 2019-02-22 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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5QP3
 | | PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z1494850193 | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DCP2 (NUDT20), ... | | 著者 | Nelson, E.R, Velupillai, S, Talon, R, Collins, P.M, Krojer, T, Wang, D, Brandao-Neto, J, Douangamath, A, Burgess-Brown, N, Arrowsmith, C.H, Bountra, C, Huber, K, von Delft, F. | | 登録日 | 2019-02-22 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | PanDDA analysis group deposition
To Be Published
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4ER7
 | | Crystal Structure of human DOT1L in complex with inhibitor SGC0947 | | 分子名称: | 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, GLYCEROL, Histone-lysine N-methyltransferase, ... | | 著者 | Wernimont, A.K, Tempel, W, Yu, W, Scopton, A, Li, Y, Nguyen, K.T, Vedadi, M, Bradner, J.E, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2012-04-19 | | 公開日 | 2012-05-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Nat Commun, 3, 2012
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8CIS
 | | The FERM domain of human moesin with two bound peptides identified by phage display | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, C3P, ... | | 著者 | Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E. | | 登録日 | 2023-02-10 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
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8SGL
 | | CCT G beta 5 complex closed state 15 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Guanine nucleotide-binding protein subunit beta-5, ... | | 著者 | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | | 登録日 | 2023-04-12 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller.
Mol.Cell, 83, 2023
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2HJO
 | | Crystal structure of V224H design intermediate for GFP metal ion reporter | | 分子名称: | 1,2-ETHANEDIOL, Green Fluorescent Protein, MAGNESIUM ION | | 著者 | Barondeau, D.P, Tubbs, J.L, Tainer, J.A, Getzoff, E.D. | | 登録日 | 2006-06-30 | | 公開日 | 2008-04-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Iterative Structure-Based Design of a Green
Fluorescent Protein Metal Ion Reporter
To be Published
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8SGC
 | | CCT G beta 5 complex closed state 2 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Guanine nucleotide-binding protein subunit beta-5, ... | | 著者 | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | | 登録日 | 2023-04-12 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller.
Mol.Cell, 83, 2023
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1ST7
 | | Solution structure of Acyl Coenzyme A Binding Protein from yeast | | 分子名称: | Acyl-CoA-binding protein | | 著者 | Teilum, K, Thormann, T, Caterer, N.R, Poulsen, H.I, Jensen, P.H, Knudsen, J, Kragelund, B.B, Poulsen, F.M. | | 登録日 | 2004-03-25 | | 公開日 | 2005-03-01 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Different secondary structure elements as scaffolds for protein folding transition states of two homologous four-helix bundles
Proteins, 59, 2005
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8CIR
 | | The FERM domain of human moesin with a bound peptide identified by phage display | | 分子名称: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BROMIDE ION, ... | | 著者 | Bradshaw, W.J, Katis, V.L, Leisner, T.M, Fairhead, M, Bountra, C, von Delft, F, Pearce, K.H, Brennan, P.E. | | 登録日 | 2023-02-10 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
J.Biol.Chem., 299, 2023
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8SFE
 | | Open state CCT-G beta 5 complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | | 著者 | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller.
Mol.Cell, 83, 2023
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8SFF
 | | CCT G beta 5 complex closed state 0 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | | 著者 | Wang, S, Sass, M, Willardson, B.M, Shen, P.S. | | 登録日 | 2023-04-11 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller.
Mol.Cell, 83, 2023
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4ETP
 | | C-terminal motor and motor homology domain of Kar3Vik1 fused to a synthetic heterodimeric coiled coil | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Kinesin-like protein KAR3, ... | | 著者 | Rank, K.C, Chen, C.J, Cope, J, Porche, K, Hoenger, A, Gilbert, S.P, Rayment, I. | | 登録日 | 2012-04-24 | | 公開日 | 2012-06-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Kar3Vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern.
J.Cell Biol., 197, 2012
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