8C7Y

Crystal structure of BRAF V600E in complex with a hybrid compound 6

Summary for 8C7Y

Entry DOI	10.2210/pdb8c7y/pdb
Descriptor	Serine/threonine-protein kinase B-raf, 1,2-ETHANEDIOL, NITRATE ION, ... (5 entities in total)
Functional Keywords	braf, kinase, kinase inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	66446.62
Authors	Chaikuad, A.,Bonnet, P.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-01-17, release date: 2023-02-22, Last modification date: 2023-04-19)
Primary citation	Arora, R.,Linders, J.T.M.,Aci-Seche, S.,Verheyen, T.,Van Heerde, E.,Brehmer, D.,Chaikuad, A.,Knapp, S.,Bonnet, P. Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor. Eur.J.Med.Chem., 250:115231-115231, 2023 Cited by PubMed: 36878151 DOI: 10.1016/j.ejmech.2023.115231 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation