7CFX
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![BU of 7cfx by Molmil](/molmil-images/mine/7cfx) | NAD-soaked Holo-methanol dehydrogenase (MDH) from Methylococcus capsulatus (Bath) | 分子名称: | CALCIUM ION, Methanol dehydrogenase [cytochrome c] subunit 2, Methanol dehydrogenase protein, ... | 著者 | Chuankhayan, P, Chan, S.I, Nareddy, P.K.R, Tsai, I.K, Tsai, Y.F, Chen, K.H.-C, Yu, S.S.-F, Chen, C.J. | 登録日 | 2020-06-29 | 公開日 | 2021-06-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mechanism of Pyrroloquinoline Quinone-Dependent Hydride Transfer Chemistry from Spectroscopic and High-Resolution X-ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath). J.Am.Chem.Soc., 143, 2021
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7CED
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![BU of 7ced by Molmil](/molmil-images/mine/7ced) | Apo-methanol dehydrogenase (MDH) from Methylococcus capsulatus (Bath) | 分子名称: | Methanol dehydrogenase [cytochrome c] subunit 2, Methanol dehydrogenase protein, large subunit | 著者 | Chuankhayan, P, Chan, S.I, Nareddy, P.K.R, Tsai, I.K, Tsai, Y.F, Chen, K.H.-C, Yu, S.S.-F, Chen, C.J. | 登録日 | 2020-06-22 | 公開日 | 2021-06-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Mechanism of Pyrroloquinoline Quinone-Dependent Hydride Transfer Chemistry from Spectroscopic and High-Resolution X-ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath). J.Am.Chem.Soc., 143, 2021
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7NMQ
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7NG6
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![BU of 7ng6 by Molmil](/molmil-images/mine/7ng6) | Crystal structure of MG-132 covalently bound to the main protease (3CLpro/Mpro) of SARS-CoV-2 in spacegroup P1 in absence of DTT. | 分子名称: | 3C-like proteinase, ACETATE ION, CHLORIDE ION, ... | 著者 | Costanzi, E, Demitri, N, Giabbai, B, Storici, P. | 登録日 | 2021-02-08 | 公開日 | 2021-04-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-L. Int J Mol Sci, 22, 2021
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7CE5
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![BU of 7ce5 by Molmil](/molmil-images/mine/7ce5) | Methanol-PQQ bound methanol dehydrogenase (MDH) from Methylococcus capsulatus (Bath) | 分子名称: | CALCIUM ION, METHANOL, Methanol dehydrogenase [cytochrome c] subunit 2, ... | 著者 | Chuankhayan, P, Chan, S.I, Nareddy, P.K.R, Tsai, I.K, Tsai, Y.F, Chen, K.H.-C, Yu, S.S.-F, Chen, C.J. | 登録日 | 2020-06-22 | 公開日 | 2021-06-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of Pyrroloquinoline Quinone-Dependent Hydride Transfer Chemistry from Spectroscopic and High-Resolution X-ray Structural Studies of the Methanol Dehydrogenase from Methylococcus capsulatus (Bath). J.Am.Chem.Soc., 143, 2021
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4F8Z
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![BU of 4f8z by Molmil](/molmil-images/mine/4f8z) | Carboxypeptidase T with Boc-Leu | 分子名称: | CALCIUM ION, Carboxypeptidase T, GLYCEROL, ... | 著者 | Timofeev, V.I, Kuznetsov, S.A, Akparov, V.K, Kuranova, I.P. | 登録日 | 2012-05-18 | 公開日 | 2013-05-22 | 最終更新日 | 2015-09-30 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Three-dimensional structure of carboxypeptidase T from Thermoactinomyces vulgaris in complex with N-BOC-L-leucine. Biochemistry Mosc., 78, 2013
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5ECU
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6DF5
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![BU of 6df5 by Molmil](/molmil-images/mine/6df5) | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with the specific Kaiso binding sequence (KBS) | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), ... | 著者 | Nikolova, E.N, Stanfield, R.L, Dyson, H.J, Wright, P.E. | 登録日 | 2018-05-14 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.819 Å) | 主引用文献 | A conformational switch in the zinc finger protein Kaiso mediates differential readout of specific and methylated DNA sequences. Biochemistry, 2020
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6DFB
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![BU of 6dfb by Molmil](/molmil-images/mine/6dfb) | Kaiso (ZBTB33) K539A zinc finger DNA binding domain in complex with the specific Kaiso binding sequence (KBS) | 分子名称: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), ... | 著者 | Nikolova, E.N, Stanfield, R.L, Dyson, H.J, Wright, P.E. | 登録日 | 2018-05-14 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | A conformational switch in the zinc finger protein Kaiso mediates differential readout of specific and methylated DNA sequences. Biochemistry, 2020
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3KRV
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![BU of 3krv by Molmil](/molmil-images/mine/3krv) | The Structure Of Potential Metal-Dependent Hydrolase With Cyclase Activity | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Rakonjac, N, Rezacova, P, Borek, D, Collart, F, Joachimiak, A, Otwinowski, Z, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2009-11-19 | 公開日 | 2010-01-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | The Structure Of Potential Metal-Dependent Hydrolase With Cyclase Activity To be Published
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7NGQ
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![BU of 7ngq by Molmil](/molmil-images/mine/7ngq) | Human mitochondrial Lon protease homolog, D2-state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | 著者 | Mohammed, I, Abrahams, J.P, Schmitz, K.A, Maier, T, Schenck, N. | 登録日 | 2021-02-09 | 公開日 | 2021-04-28 | 最終更新日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (12 Å) | 主引用文献 | Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022
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3KTX
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![BU of 3ktx by Molmil](/molmil-images/mine/3ktx) | Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK)in complex with 1,3,6,8-pyrenetetrasulfonic acid | 分子名称: | GLYCEROL, Pyruvate kinase, pyrene-1,3,6,8-tetrasulfonic acid | 著者 | Morgan, H.P, Walkinshaw, M.D. | 登録日 | 2009-11-26 | 公開日 | 2010-02-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase. Acta Crystallogr.,Sect.F, 66, 2010
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7NGP
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![BU of 7ngp by Molmil](/molmil-images/mine/7ngp) | D1-state of wild type human mitochondrial LONP1 protease | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | 著者 | Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T, Abrahams, J.P. | 登録日 | 2021-02-09 | 公開日 | 2021-04-28 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (15 Å) | 主引用文献 | Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022
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7NGL
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![BU of 7ngl by Molmil](/molmil-images/mine/7ngl) | R-state of wild type human mitochondrial LONP1 protease bound to endogenous ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | 著者 | Mohammed, I, Schmitz, K.A, Schenck, N, Maier, T, Abrahams, J.P. | 登録日 | 2021-02-09 | 公開日 | 2021-04-28 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Catalytic cycling of human mitochondrial Lon protease. Structure, 30, 2022
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4FLP
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![BU of 4flp by Molmil](/molmil-images/mine/4flp) | Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor JQ1 | 分子名称: | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, Bromodomain testis-specific protein, POTASSIUM ION | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, Canning, P, Muniz, J, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Bradner, J, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2012-06-15 | 公開日 | 2012-07-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Small-Molecule Inhibition of BRDT for Male Contraception. Cell(Cambridge,Mass.), 150, 2012
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6DN5
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5DYE
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![BU of 5dye by Molmil](/molmil-images/mine/5dye) | CRYSTAL STRUCTURE OF THE FULL LENGTH S156E MUTANT OF HUMAN AQUAPORIN 5 | 分子名称: | Aquaporin-5, O-[(S)-{[(2S)-2-(hexanoyloxy)-3-(tetradecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-D-serine | 著者 | Kitchen, P, Oeberg, F, Sjoehamn, J, Hedfalk, K, Bill, R.M, Conner, A.C, Conner, M.T, Toernroth-Horsefield, S. | 登録日 | 2015-09-24 | 公開日 | 2015-12-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways. Plos One, 10, 2015
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5L2W
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![BU of 5l2w by Molmil](/molmil-images/mine/5l2w) | The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib. | 分子名称: | 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, ... | 著者 | Chen, P, Ferre, R.A, Deihl, W, Yu, X, He, Y.-A. | 登録日 | 2016-08-02 | 公開日 | 2016-08-24 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance. Mol.Cancer Ther., 15, 2016
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7COW
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![BU of 7cow by Molmil](/molmil-images/mine/7cow) | 353 bp di-nucleosome harboring cohesive DNA termini with linker histone H1.0 | 分子名称: | CALCIUM ION, CHLORIDE ION, DNA (353-MER), ... | 著者 | Adhireksan, Z, Sharma, D, Lee, P.L, Davey, C.A. | 登録日 | 2020-08-05 | 公開日 | 2021-08-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Engineering nucleosomes for generating diverse chromatin assemblies. Nucleic Acids Res., 49, 2021
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3KVV
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![BU of 3kvv by Molmil](/molmil-images/mine/3kvv) | Trapping of an oxocarbenium ion intermediate in UP crystals | 分子名称: | 1,4-anhydro-D-erythro-pent-1-enitol, 5-FLUOROURACIL, SULFATE ION, ... | 著者 | Paul, D, O'Leary, S, Rajashankar, K, Bu, W, Toms, A, Settembre, E, Sanders, J, Begley, T.P, Ealick, S.E. | 登録日 | 2009-11-30 | 公開日 | 2010-04-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Glycal formation in crystals of uridine phosphorylase. Biochemistry, 49, 2010
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5KZQ
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![BU of 5kzq by Molmil](/molmil-images/mine/5kzq) | Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid | 分子名称: | (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 2 | 著者 | Chappell, M.D, Li, R, Smith, S.C, Dressman, B.A, Tromiczak, E.G, Tripp, A.E, Blanco, M.-J, Vetman, T, Quimby, S.J, Matt, J, Britton, T, Fivush, A.M, Schkeryantz, J.M, Mayhugh, D, Erickson, J.A, Bures, M, Jaramillo, C, Carpintero, M, de Diego, J.E, Barberis, M, Garcia-Cerrada, S, Soriano, J.F, Antonysamy, S, Atwell, S, MacEwan, I, Condon, B, Bradley, C, Wang, J, Zhang, A, Conners, K, Groshong, C, Wasserman, S.R, Koss, J.W, Witkin, J.M, Li, X, Overshiner, C, Wafford, K.A, Seidel, W, Wang, X.-S, Heinz, B.A, Swanson, S, Catlow, J, Bedwell, D, Monn, J.A, Mitch, C.H, Ornstein, P. | 登録日 | 2016-07-25 | 公開日 | 2016-12-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. J. Med. Chem., 59, 2016
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5L02
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![BU of 5l02 by Molmil](/molmil-images/mine/5l02) | S324T variant of B. pseudomallei KatG | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Catalase-peroxidase, PHOSPHATE ION, ... | 著者 | Loewen, P.C. | 登録日 | 2016-07-26 | 公開日 | 2016-08-10 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural characterization of the Ser324Thr variant of the catalase-peroxidase (KatG) from Burkholderia pseudomallei J. Mol. Biol., 345, 2005
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6DVH
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5E7P
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![BU of 5e7p by Molmil](/molmil-images/mine/5e7p) | Crystal Structure of MSMEG_0858 (Uniprot A0QQS4), a AAA ATPase. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein Cdc48, GLYCEROL, ... | 著者 | Unciulac-Carp, M, Smith, P, Shuman, S. | 登録日 | 2015-10-12 | 公開日 | 2016-08-24 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.507 Å) | 主引用文献 | Crystal Structure and Biochemical Characterization of a Mycobacterium smegmatis AAA-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858). J.Bacteriol., 198, 2016
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4FEE
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![BU of 4fee by Molmil](/molmil-images/mine/4fee) | High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal B | 分子名称: | 2-[(2E)-3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-HYDROXYETHYLIDENE)-4-METHYL-2,3-DIHYDRO-1,3-THIAZOL-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Meyer, D, Neumann, P, Koers, E, Sjuts, H, Luedtke, S, Sheldrick, G.M, Ficner, R, Tittmann, K. | 登録日 | 2012-05-30 | 公開日 | 2012-06-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin. Proc.Natl.Acad.Sci.USA, 109, 2012
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