4FLP
Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor JQ1
Summary for 4FLP
Entry DOI | 10.2210/pdb4flp/pdb |
Related | 2RFJ |
Descriptor | Bromodomain testis-specific protein, (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | brdt, bromodomain containing protein testis specific, nucleus, transcription, transcription regulation, structural genomics consortium, sgc, bromodomain, transcription regulator-inhibitor complex, transcription regulator/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (Probable): Q58F21 |
Total number of polymer chains | 2 |
Total formula weight | 29287.94 |
Authors | Filippakopoulos, P.,Picaud, S.,Qi, J.,Felletar, I.,Canning, P.,Muniz, J.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Bradner, J.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2012-06-15, release date: 2012-07-11, Last modification date: 2023-09-13) |
Primary citation | Matzuk, M.M.,McKeown, M.R.,Filippakopoulos, P.,Li, Q.,Ma, L.,Agno, J.E.,Lemieux, M.E.,Picaud, S.,Yu, R.N.,Qi, J.,Knapp, S.,Bradner, J.E. Small-Molecule Inhibition of BRDT for Male Contraception. Cell(Cambridge,Mass.), 150:673-684, 2012 Cited by PubMed: 22901802DOI: 10.1016/j.cell.2012.06.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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