4FLP
Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor JQ1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain testis-specific protein | polymer | 119 | 14166.4 | 2 | UniProt (Q58F21) Pfam (PF00439) | Homo sapiens (human) | Cancer/testis antigen 9, CT9, RING3-like protein |
| 2 | C, D (A, B) | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium | non-polymer | 458.0 | 2 | Chemie (JQ1) | |||
| 3 | E (B) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 137 (UniProt: Q58F21)
| PDB | External Database | Details |
|---|---|---|
| Ser 19 | - | expression tag |
| Met 20 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28332.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 955.1 | |
| All* | Total formula weight | 29287.9 |
