8WGU
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![BU of 8wgu by Molmil](/molmil-images/mine/8wgu) | Crystal structure of V30M-TTR in complex with compound 20 | 分子名称: | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-[2-ethyl-4,7-bis(fluoranyl)-1-benzofuran-3-yl]methanone | 著者 | Yokoyama, T. | 登録日 | 2023-09-22 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.508 Å) | 主引用文献 | Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67, 2024
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4QRF
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![BU of 4qrf by Molmil](/molmil-images/mine/4qrf) | Crystal structure of V30M mutant human transthyretin complexed with caffeic acid phenethyl ester | 分子名称: | 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | 登録日 | 2014-06-30 | 公開日 | 2014-11-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Inhibitory Activities of Propolis and Its Promising Component, Caffeic Acid Phenethyl Ester, against Amyloidogenesis of Human Transthyretin J.Med.Chem., 57, 2014
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6IP6
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![BU of 6ip6 by Molmil](/molmil-images/mine/6ip6) | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | 登録日 | 2018-11-02 | 公開日 | 2019-05-29 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
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6IP8
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![BU of 6ip8 by Molmil](/molmil-images/mine/6ip8) | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | 登録日 | 2018-11-02 | 公開日 | 2019-05-29 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
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8IP8
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![BU of 8ip8 by Molmil](/molmil-images/mine/8ip8) | Wheat 80S ribosome stalled on AUG-Stop boron dependently | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein eL8, 40S ribosomal protein eS1, ... | 著者 | Yokoyama, T, Tanaka, M, Saito, H, Nishimoto, M, Tsuda, K, Sotta, N, Shigematsu, H, Shirouzu, M, Iwasaki, S, Ito, T, Fujiwara, T. | 登録日 | 2023-03-14 | 公開日 | 2024-02-21 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1. Nat.Chem.Biol., 20, 2024
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6IP5
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![BU of 6ip5 by Molmil](/molmil-images/mine/6ip5) | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | 著者 | Yokoyama, T, Shigematsu, H, Shirouzu, M, Imataka, H, Ito, T. | 登録日 | 2018-11-02 | 公開日 | 2019-05-29 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | HCV IRES Captures an Actively Translating 80S Ribosome. Mol.Cell, 74, 2019
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8I74
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![BU of 8i74 by Molmil](/molmil-images/mine/8i74) | |
8I75
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![BU of 8i75 by Molmil](/molmil-images/mine/8i75) | |
8I76
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![BU of 8i76 by Molmil](/molmil-images/mine/8i76) | |
5AYT
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![BU of 5ayt by Molmil](/molmil-images/mine/5ayt) | Crystal structure of transthyretin in complex with L6 | 分子名称: | 2-oxidanyl-6-(phenylcarbonyl)benzo[de]isoquinoline-1,3-dione, Transthyretin | 著者 | Yokoyama, T, Mizuguchi, M, Kai, H. | 登録日 | 2015-09-03 | 公開日 | 2016-01-20 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural stabilization of transthyretin by a new compound, 6-benzoyl-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione J. Pharmacol. Sci., 129, 2015
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5H0Z
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![BU of 5h0z by Molmil](/molmil-images/mine/5h0z) | Crystal structure of P113A mutated human transthyretin | 分子名称: | CHLORIDE ION, SULFATE ION, Transthyretin | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | 登録日 | 2016-10-07 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.735 Å) | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins FEBS Lett., 591, 2017
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5H0V
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![BU of 5h0v by Molmil](/molmil-images/mine/5h0v) | Crystal structure of H88A mutated human transthyretin | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, Transthyretin | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | 登録日 | 2016-10-07 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins FEBS Lett., 591, 2017
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5H0X
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![BU of 5h0x by Molmil](/molmil-images/mine/5h0x) | |
5H0W
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![BU of 5h0w by Molmil](/molmil-images/mine/5h0w) | Crystal structure of H88F mutated human transthyretin | 分子名称: | SULFATE ION, Transthyretin | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | 登録日 | 2016-10-07 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins FEBS Lett., 591, 2017
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5H0Y
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![BU of 5h0y by Molmil](/molmil-images/mine/5h0y) | Crystal structure of H88Y mutated human transthyretin | 分子名称: | CHLORIDE ION, SULFATE ION, Transthyretin | 著者 | Yokoyama, T, Hanawa, Y, Obita, T, Mizuguchi, M. | 登録日 | 2016-10-07 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Stability and crystal structures of His88 mutant human transthyretins FEBS Lett., 591, 2017
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3J0E
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![BU of 3j0e by Molmil](/molmil-images/mine/3j0e) | Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex | 分子名称: | 30S ribosomal protein S12, Elongation factor G, Ribosome-recycling factor, ... | 著者 | Yokoyama, T, Shaikh, T.R, Iwakura, N, Kaji, H, Kaji, A, Agrawal, R.K. | 登録日 | 2011-06-29 | 公開日 | 2012-04-25 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (9.9 Å) | 主引用文献 | Structural insights into initial and intermediate steps of the ribosome-recycling process. Embo J., 31, 2012
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8W42
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![BU of 8w42 by Molmil](/molmil-images/mine/8w42) | |
8W44
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![BU of 8w44 by Molmil](/molmil-images/mine/8w44) | |
8W46
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![BU of 8w46 by Molmil](/molmil-images/mine/8w46) | |
8W48
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![BU of 8w48 by Molmil](/molmil-images/mine/8w48) | |
8W43
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![BU of 8w43 by Molmil](/molmil-images/mine/8w43) | |
8W45
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![BU of 8w45 by Molmil](/molmil-images/mine/8w45) | X-ray crystal structure of V30M-TTR in complex with pinostilbene | 分子名称: | 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, SODIUM ION, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-08-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
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8W47
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![BU of 8w47 by Molmil](/molmil-images/mine/8w47) | X-ray crystal structure of V30M-TTR in complex with isorhapontigenin | 分子名称: | 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol, SODIUM ION, Transthyretin | 著者 | Yokoyama, T. | 登録日 | 2023-08-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
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3U2J
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![BU of 3u2j by Molmil](/molmil-images/mine/3u2j) | Neutron crystal structure of human Transthyretin | 分子名称: | Transthyretin | 著者 | Yokoyama, T, Mizuguchi, M, Nabeshima, Y, Kusaka, K, Yamada, T, Hosoya, T, Ohhara, T, Kurihara, K, Tomoyori, K, Tanaka, I, Niimura, N. | 登録日 | 2011-10-03 | 公開日 | 2012-02-22 | 最終更新日 | 2023-11-01 | 実験手法 | NEUTRON DIFFRACTION (2 Å) | 主引用文献 | Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin J.Struct.Biol., 177, 2012
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3U2I
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![BU of 3u2i by Molmil](/molmil-images/mine/3u2i) | X-ray crystal structure of human Transthyretin at room temperature | 分子名称: | Transthyretin | 著者 | Yokoyama, T, Mizuguchi, M, Nabeshima, Y, Kusaka, K, Yamada, T, Hosoya, T, Ohhara, T, Kurihara, K, Tomoyori, K, Tanaka, I, Niimura, N. | 登録日 | 2011-10-03 | 公開日 | 2012-02-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin J.Struct.Biol., 177, 2012
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