Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 472 results

7OBL
DownloadVisualize
BU of 7obl by Molmil
Crystal structure of 14-3-3 sigma in complex with PKR phosphopeptide and stabilizer Fusicoccin-A
Descriptor: 14-3-3 protein sigma, FUSICOCCIN, MAGNESIUM ION, ...
Authors:Centorrino, F, Andlovic, B, Ottmann, C.
Deposit date:2021-04-22
Release date:2022-05-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Cell Chem Biol, 2023
7OBC
DownloadVisualize
BU of 7obc by Molmil
Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, FARNESYL, ...
Authors:Centorrino, F, Andlovic, B, Ottmann, C.
Deposit date:2021-04-21
Release date:2022-05-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Cell Chem Biol, 2023
7OPW
DownloadVisualize
BU of 7opw by Molmil
Ternary complex of 14-3-3 sigma, Estrogen Receptor alfa phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-01
Release date:2022-06-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQG
DownloadVisualize
BU of 7oqg by Molmil
Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), BETA-MERCAPTOETHANOL, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-03
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQJ
DownloadVisualize
BU of 7oqj by Molmil
Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ162
Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CHLORIDE ION, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-03
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQS
DownloadVisualize
BU of 7oqs by Molmil
Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ177
Descriptor: 14-3-3 protein sigma, 2-(1,3-benzodioxol-5-yl)-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]ethanamide, Amot-p130 phosphopeptide (pS175), ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-04
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OR3
DownloadVisualize
BU of 7or3 by Molmil
Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-04
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7ORS
DownloadVisualize
BU of 7ors by Molmil
Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ147
Descriptor: (4~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]oxepane-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-06
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OR8
DownloadVisualize
BU of 7or8 by Molmil
Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ136
Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-04
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7ORT
DownloadVisualize
BU of 7ort by Molmil
Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ176
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-06
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
3T0L
DownloadVisualize
BU of 3t0l by Molmil
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ...
Authors:Thiel, P, Ottmann, C.
Deposit date:2011-07-20
Release date:2012-12-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
Chem.Commun.(Camb.), 49, 2013
7OQU
DownloadVisualize
BU of 7oqu by Molmil
Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ180
Descriptor: (2~{S},3~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-3-methyl-2,3-dihydro-1-benzofuran-2-carboxamide, 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-04
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7ORG
DownloadVisualize
BU of 7org by Molmil
Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ162
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-05
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQW
DownloadVisualize
BU of 7oqw by Molmil
Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ178
Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), MAGNESIUM ION, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-04
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7ORH
DownloadVisualize
BU of 7orh by Molmil
Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ178
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ...
Authors:Centorrino, F, Wu, Q, Ottmann, C.
Deposit date:2021-06-05
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQ8
DownloadVisualize
BU of 7oq8 by Molmil
Ternary complex of 14-3-3 sigma, Estrogen Receptor alfa phosphopeptide, and WQ178
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Estrogen receptor, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-02
Release date:2022-06-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
7OQ7
DownloadVisualize
BU of 7oq7 by Molmil
Ternary complex of 14-3-3 sigma, Estrogen Receptor alfa phosphopeptide, and WQ162
Descriptor: 14-3-3 protein sigma, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Centorrino, F, Ottmann, C.
Deposit date:2021-06-02
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A crystallography-based study of fragment extensions into the 14-3-3 binding groove
To Be Published
6Y3W
DownloadVisualize
BU of 6y3w by Molmil
Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 1
Descriptor: 14-3-3 protein sigma, 3-fluoranyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ...
Authors:Somsen, B.A, Ottmann, C.
Deposit date:2020-02-19
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers.
Acs Chem.Biol., 15, 2020
6YLU
DownloadVisualize
BU of 6ylu by Molmil
14-3-3sigma in complex with BLNKpT152 phosphopeptide crystal structure
Descriptor: 14-3-3 protein sigma, BLNKpT152, MAGNESIUM ION
Authors:Soini, L, Leysen, S, Davis, J, Ottmann, C.
Deposit date:2020-04-07
Release date:2020-12-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:14-3-3sigma in complex with BLNKpT152 phosphopeptide crystal structure
J.Struct.Biol., 2020
6Y1D
DownloadVisualize
BU of 6y1d by Molmil
Binary complex of 14-3-3 sigma (C38N) with the Estrogen Related Receptor gamma (DBD) phosphopeptide
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, Estrogen related receptor gamma phosphopeptide, ...
Authors:Somsen, B.A, Ottmann, C.
Deposit date:2020-02-12
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers.
Acs Chem.Biol., 15, 2020
3UBW
DownloadVisualize
BU of 3ubw by Molmil
Complex of 14-3-3 isoform epsilon, a Mlf1 phosphopeptide and a small fragment hit from a FBDD screen
Descriptor: (3S)-pyrrolidin-3-ol, 14-3-3 protein epsilon, Myeloid leukemia factor 1, ...
Authors:Molzan, M, Weyand, M, Rose, R, Ottmann, C.
Deposit date:2011-10-25
Release date:2012-01-25
Last modified:2012-02-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights of the MLF1/14-3-3 interaction.
Febs J., 279, 2012
6Y8E
DownloadVisualize
BU of 6y8e by Molmil
14-3-3 Sigma in complex with phosphorylated MLF1 peptide
Descriptor: 14-3-3 protein sigma, ARG-SER-PHE-SEP-GLU-PRO-PHE-GLY, CALCIUM ION, ...
Authors:Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
Deposit date:2020-03-04
Release date:2020-10-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:A new soaking procedure for X-ray crystallographic structural determination of protein-peptide complexes.
Acta Crystallogr.,Sect.F, 76, 2020
6FNA
DownloadVisualize
BU of 6fna by Molmil
Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins
Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ...
Authors:Bier, D, Ottmann, C.
Deposit date:2018-02-02
Release date:2018-07-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins.
Chemistry, 24, 2018
3U9X
DownloadVisualize
BU of 3u9x by Molmil
Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins
Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ...
Authors:Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C.
Deposit date:2011-10-20
Release date:2012-05-09
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Covalent attachment of pyridoxal-phosphate derivatives to 14-3-3 proteins.
Proc.Natl.Acad.Sci.USA, 109, 2012
3T0M
DownloadVisualize
BU of 3t0m by Molmil
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Descriptor: (2-{2-[(2,5-dimethoxyphenyl)amino]-2-oxoethoxy}phenyl)phosphonic acid, 14-3-3 protein sigma, CHLORIDE ION, ...
Authors:Thiel, P, Ottmann, C.
Deposit date:2011-07-20
Release date:2012-12-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
Chem.Commun.(Camb.), 49, 2013

222926

数据于2024-07-24公开中

PDB statisticsPDBj update infoContact PDBjnumon