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PDB: 477 件
8BZG
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BU of 8bzg by Molmil
FC-31 stabilizer of 14-3-3 and ERalpha
分子名称: 14-3-3 protein sigma, ERalpha peptide, Fusicoccin 31, ...
著者Visser, E.J, Ottmann, C.
登録日2022-12-14
公開日2024-06-26
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
8BZT
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BU of 8bzt by Molmil
FC-NAg stabilizer of 14-3-3 and ERalpha
分子名称: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ...
著者Visser, E.J, Ottmann, C.
登録日2022-12-15
公開日2024-06-26
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
8C0L
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BU of 8c0l by Molmil
FC-THF stabilizer of 14-3-3 and ERalpha
分子名称: 14-3-3 protein sigma, ERalpha peptide, Fusicoccin A-THF
著者Visser, E.J, Ottmann, C.
登録日2022-12-17
公開日2024-07-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer
To Be Published
4J24
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BU of 4j24 by Molmil
Estrogen Receptor in complex with proline-flanked LXXLL peptides
分子名称: 19-mer peptide, ESTRADIOL, Estrogen receptor beta
著者Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L.
登録日2013-02-04
公開日2013-03-13
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction
J.Am.Chem.Soc., 135, 2013
6ZVC
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BU of 6zvc by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 48h incubation
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
著者Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
登録日2020-07-24
公開日2021-08-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6ZVB
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BU of 6zvb by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 24h incubation
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
著者Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
登録日2020-07-24
公開日2021-08-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6ZVD
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BU of 6zvd by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 96h incubation
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
著者Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
登録日2020-07-24
公開日2021-08-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6ZVE
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BU of 6zve by Molmil
14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 1h incubation
分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide
著者Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C.
登録日2020-07-24
公開日2021-08-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes
To Be Published
6FI4
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BU of 6fi4 by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 3.2e with 14-3-3sigma
分子名称: (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CALCIUM ION, ...
著者Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G.
登録日2018-01-17
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.
ACS Chem Neurosci, 9, 2018
6FBY
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BU of 6fby by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 4.2b with 14-3-3sigma
分子名称: (2~{R})-2-[(~{S})-(3-methylphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ...
著者Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G.
登録日2017-12-20
公開日2018-05-16
最終更新日2019-02-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.
ACS Chem Neurosci, 9, 2018
6FI5
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BU of 6fi5 by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 3.2d with 14-3-3sigma
分子名称: (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CHLORIDE ION, ...
著者Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G.
登録日2018-01-17
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.
ACS Chem Neurosci, 9, 2018
6FAW
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BU of 6faw by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 4.2c-I with 14-3-3sigma
分子名称: (2~{R})-2-[(~{R})-[2-(2-methoxyethoxy)phenyl]-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ...
著者Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G.
登録日2017-12-18
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.
ACS Chem Neurosci, 9, 2018
6FBW
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BU of 6fbw by Molmil
Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-II with 14-3-3sigma
分子名称: (2~{R})-2-[(~{S})-(3-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-GLY, ...
著者Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G.
登録日2017-12-20
公開日2018-05-16
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.
ACS Chem Neurosci, 9, 2018
3MHR
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BU of 3mhr by Molmil
14-3-3 sigma in complex with YAP pS127-peptide
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Schumacher, B, Skwarczynska, M, Rose, R, Ottmann, C.
登録日2010-04-08
公開日2010-09-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Structure of a 14-3-3[sigma]-YAP phosphopeptide complex at 1.15 A resolution
Acta Crystallogr.,Sect.F, 66, 2010
6HEP
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BU of 6hep by Molmil
Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768
分子名称: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator
著者Stevers, L.M, Ottmann, C, Brunsveld, L.
登録日2018-08-20
公開日2018-10-24
最終更新日2018-11-07
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions.
J. Am. Chem. Soc., 140, 2018
5N75
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BU of 5n75 by Molmil
14-3-3 sigma in complex with TAZ pS89 peptide
分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ...
著者Sijbesma, E, Leysen, S, Ottmann, C.
登録日2017-02-19
公開日2017-07-19
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.803 Å)
主引用文献Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
5N5R
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BU of 5n5r by Molmil
14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV1
分子名称: 14-3-3 protein sigma, 2-azanyl-~{N}-(2,6-dimethylphenyl)-~{N}-propan-2-yl-ethanamide, CHLORIDE ION, ...
著者Sijbesma, E, Leysen, S, Ottmann, C.
登録日2017-02-14
公開日2017-07-19
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
6GHP
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BU of 6ghp by Molmil
14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc
分子名称: 14-3-3 protein sigma, CHLORIDE ION, Potassium channel subfamily K member 9, ...
著者Andrei, S.A, de Vink, P.J, Brunsveld, L, Ottmann, C, Higuchi, Y.
登録日2018-05-08
公開日2018-08-01
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions.
Angew. Chem. Int. Ed. Engl., 57, 2018
5EC9
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BU of 5ec9 by Molmil
Retinoic acid receptor alpha in complex with chiral dihydrobenzofuran benzoic acid 9a and a fragment of the coactivator TIF2
分子名称: 4-[(11S,15R)-4,4,7,7-Tetramethyl-16-oxatetracyclo[8.6.0.03,8.011,15]hexadeca-1(10),2,8-trien-11-yl]benzoic acid, LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, Retinoic acid receptor RXR-alpha
著者Leysen, S, Ottmann, C, Schafer, A, Scheepstra, M, Brunsveld, L, Sunden, R, Ma, J.N, Burnstein, E.S, Olsson, R.
登録日2015-10-20
公開日2016-03-09
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.
J.Med.Chem., 59, 2016
6F09
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BU of 6f09 by Molmil
Binary complex of 14-3-3 zeta with ubiquitin specific protease 8 (USP8) pSer718 peptide
分子名称: 14-3-3 protein zeta/delta, Ubiquitin carboxyl-terminal hydrolase 8
著者Centorrino, F, Ballone, A, Ottmann, C, Guo, S, Leysen, S.
登録日2017-11-17
公開日2018-03-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.594 Å)
主引用文献Biophysical and structural insight into the USP8/14-3-3 interaction.
FEBS Lett., 592, 2018
5N10
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BU of 5n10 by Molmil
Cucurbit[8]uril and 14-3-3 based binary bivalent supramolecular-protein assembly platform
分子名称: 14-3-3 protein beta/alpha, Cucurbit[8]uril, Estrogen receptor, ...
著者de Vink, P.J, Ottmann, C.
登録日2017-02-04
公開日2017-05-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.
Angew. Chem. Int. Ed. Engl., 56, 2017
5N5W
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BU of 5n5w by Molmil
14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV3
分子名称: 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyaniline, CALCIUM ION, ...
著者Sijbesma, E, Leysen, S, Ottmann, C.
登録日2017-02-14
公開日2017-07-19
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.
Biochemistry, 56, 2017
6G8K
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BU of 6g8k by Molmil
14-3-3sigma in complex with a S131beta3S mutated YAP pS127 phosphopeptide
分子名称: 14-3-3 protein sigma, ACE-ARG-ALA-HIS-SEP-SER-PRO-ALA-BSE-LEU-GLN, CHLORIDE ION, ...
著者Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G.
登録日2018-04-09
公開日2019-04-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins.
Chem.Commun.(Camb.), 55, 2019
6G8P
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BU of 6g8p by Molmil
14-3-3sigma in complex with a P129beta3P and L132beta3L mutated YAP pS127 phosphopeptide
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G.
登録日2018-04-09
公開日2019-04-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins.
Chem.Commun.(Camb.), 55, 2019
6G8L
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14-3-3sigma in complex with a L132beta3L mutated YAP pS127 phosphopeptide
分子名称: 14-3-3 protein sigma, ACE-ARG-ALA-HIS-SEP-SER-PRO-ALA-SER-BLE-GLN, CHLORIDE ION, ...
著者Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G.
登録日2018-04-09
公開日2019-04-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins.
Chem.Commun.(Camb.), 55, 2019

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