8UXG
 
 | | Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 | | Descriptor: | 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2023-11-09 | | Release date: | 2023-11-22 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.08 Å) | | Cite: | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nat Commun, 15, 2024
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8UXH
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8UXF
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8UXL
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8UXM
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8UXI
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7PQT
 | | Apo human Kv3.1 cryo-EM structure | | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1 | | Authors: | Botte, M, Huber, S, Bucher, D, Klint, J.K, Rodriguez, D, Tagmose, L, Chami, M, Cheng, R, Hennig, M, Abdul Rhaman, W. | | Deposit date: | 2021-09-20 | | Release date: | 2022-08-17 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators.
Pnas Nexus, 1, 2022
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7PQU
 | | Ligand-bound human Kv3.1 cryo-EM structure (Lu AG00563) | | Descriptor: | 1-(4-methylphenyl)sulfonyl-N-(1,3-oxazol-2-ylmethyl)pyrrole-3-carboxamide, POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1 | | Authors: | Botte, M, Huber, S, Bucher, D, Klint, J.K, Rodriguez, D, Tagmose, L, Chami, M, Cheng, R, Hennig, M, Abdul Rhaman, W. | | Deposit date: | 2021-09-20 | | Release date: | 2022-08-17 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators.
Pnas Nexus, 1, 2022
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1ERD
 | | THE NMR SOLUTION STRUCTURE OF THE PHEROMONE ER-2 FROM THE CILIATED PROTOZOAN EUPLOTES RAIKOVI | | Descriptor: | PHEROMONE ER-2 | | Authors: | Ottiger, M, Szyperski, T, Luginbuhl, P, Ortenzi, C, Luporini, P, Bradshaw, R.A, Wuthrich, K. | | Deposit date: | 1994-02-14 | | Release date: | 1994-10-15 | | Last modified: | 2024-10-09 | | Method: | SOLUTION NMR | | Cite: | The NMR solution structure of the pheromone Er-2 from the ciliated protozoan Euplotes raikovi.
Protein Sci., 3, 1994
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3EC2
 | | Crystal structure of the DnaC helicase loader | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA replication protein DnaC, MAGNESIUM ION | | Authors: | Mott, M.L, Erzberger, J.P, Coons, M.M, Berger, J.M. | | Deposit date: | 2008-08-28 | | Release date: | 2008-11-25 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural synergy and molecular crosstalk between bacterial helicase loaders and replication initiators.
Cell(Cambridge,Mass.), 135, 2008
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4R32
 | | Crystal Structure Analysis of Pyk2 and Paxillin LD motifs | | Descriptor: | Paxillin, Protein-tyrosine kinase 2-beta | | Authors: | Vanarotti, M, Miller, D.J, Guibao, C.D, Nourse, A, Zheng, J.J. | | Deposit date: | 2014-08-13 | | Release date: | 2014-09-17 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.505 Å) | | Cite: | Structural and Mechanistic Insights into the Interaction between Pyk2 and Paxillin LD Motifs.
J.Mol.Biol., 426, 2014
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5LHY
 | | PB3 Domain of Human PLK4 (apo) | | Descriptor: | Serine/threonine-protein kinase PLK4 | | Authors: | Cottee, M.A, Johnson, S, Lea, S.M. | | Deposit date: | 2016-07-13 | | Release date: | 2017-03-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.31 Å) | | Cite: | A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.
Biol Open, 6, 2017
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3ECC
 | | Crystal structure of the DnaC helicase loader in complex with ADP-BeF3 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA replication protein DnaC, ... | | Authors: | Mott, M.L, Erzberger, J.P, Coons, M.M, Berger, J. | | Deposit date: | 2008-08-29 | | Release date: | 2008-11-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural synergy and molecular crosstalk between bacterial helicase loaders and replication initiators.
Cell(Cambridge,Mass.), 135, 2008
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9E19
 | | Structure of RyR1 in the open state in the presence of pentoxifylline | | Descriptor: | 3,7-DIMETHYL-1-(5-OXOHEXYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.04 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E1G
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9E1H
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9E1E
 | | Structure of RyR1 in the primed state in the presence of uracil | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E18
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9E1I
 | | Structure of RyR1 in the open state in the presence of oxopyricid | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E17
 | | Structure of RyR1 in the primed state in the presence of caffeine (reprocessed/reanalyzed from EMPIAR-10997, 7TZC, EMD-26205) | | Descriptor: | (2S)-3-(octadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.45 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E1B
 | | Structure of RyR1 in the open state in the presence of dyphylline | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.49 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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9E1F
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9E1A
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9E1D
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9E1C
 | | Structure of RyR1 in the primed state in the presence of IBMX | | Descriptor: | 3-ISOBUTYL-1-METHYLXANTHINE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | | Authors: | Miotto, M.C, Marks, A.R. | | Deposit date: | 2024-10-21 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.63 Å) | | Cite: | Targeting Ryanodine Receptors with Allopurinol and Xanthine Derivatives for the Treatment of Cardiac and Musculoskeletal Weakness Disorders
To Be Published
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