2BHE
 
 | | HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 5-BROMO-INDIRUBINE | | Descriptor: | (2Z)-5'-BROMO-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE AMMONIATE, CELL DIVISION PROTEIN KINASE 2 | | Authors: | Schaefer, M, Jautelat, R, Brumby, T, Briem, H, Eisenbrand, G, Schwahn, S, Krueger, M, Luecking, U, Prien, O, Siemeister, G. | | Deposit date: | 2005-01-10 | | Release date: | 2005-03-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | From the Insoluble Dye Indirubin Towards Highly Active, Soluble Cdk2-Inhibitors
Chembiochem, 6, 2005
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3TTA
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3TSL
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1MWQ
 | | Structure of HI0828, a Hypothetical Protein from Haemophilus influenzae with a Putative Active-Site Phosphohistidine | | Descriptor: | CACODYLATE ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Willis, M.A, Krajewski, W, Chalamasetty, V.R, Reddy, P, Howard, A, Herzberg, O, Structure 2 Function Project (S2F) | | Deposit date: | 2002-09-30 | | Release date: | 2003-11-25 | | Last modified: | 2019-07-24 | | Method: | X-RAY DIFFRACTION (0.99 Å) | | Cite: | Structure of YciI from Haemophilus influenzae (HI0828) reveals a ferredoxin-like alpha/beta-fold with a histidine/aspartate centered catalytic site
Proteins, 59, 2005
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4JRR
 | | Crystal structure of disulfide bond oxidoreductase DsbA1 from Legionella pneumophila | | Descriptor: | GLYCEROL, SULFATE ION, Thiol:disulfide interchange protein DsbA | | Authors: | Shumilin, I.A, Jameson-Lee, M, Cymborowski, M, Domagalski, M.J, Chertihin, O, Kpadeh, Z.Z, Yeh, A.J, Hoffman, P.S, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2013-03-21 | | Release date: | 2013-04-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Crystal structure of disulfide bond oxidoreductase DsbA1 from Legionella pneumophila
To be Published
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1OB2
 | | E. coli elongation factor EF-Tu complexed with the antibiotic kirromycin, a GTP analog, and Phe-tRNA | | Descriptor: | ELONGATION FACTOR TU, KIRROMYCIN, MAGNESIUM ION, ... | | Authors: | Kristensen, O, Nissen, P, Nyborg, J. | | Deposit date: | 2003-01-24 | | Release date: | 2004-05-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Kirromycin Defines a Specific Domain Arrangement of Elongation Factor EF-TU
To be Published
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1O7K
 | | human p47 PX domain complex with sulphates | | Descriptor: | NEUTROPHIL CYTOSOL FACTOR 1, SULFATE ION | | Authors: | Karathanassis, D, Bravo, J, Perisic, O, Pacold, C.M, Williams, R.L. | | Deposit date: | 2002-11-07 | | Release date: | 2002-11-20 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Binding of the Px Domain of P47Phox to Phosphatidylinositol 3.4-Bisphosphate and Phosphatidic Acid is Masked by an Intramolecular Interaction
Embo J., 21, 2002
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1NVO
 | | Solution structure of a four-helix bundle model, apo-DF1 | | Descriptor: | Homodimeric Alpha2 Four-Helix Bundle | | Authors: | Maglio, O, Nastri, F, Pavone, V, Lombardi, A, DeGrado, W.F. | | Deposit date: | 2003-02-04 | | Release date: | 2003-03-25 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Preorganization of molecular binding sites in designed diiron proteins
Proc.Natl.Acad.Sci.USA, 100, 2003
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4L4Q
 | | Methionine Adenosyltransferase | | Descriptor: | S-adenosylmethionine synthase | | Authors: | Schlesier, J, Siegrist, J, Gerhardt, S, Andexer, J.N, Einsle, O. | | Deposit date: | 2013-06-09 | | Release date: | 2014-03-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis.
Bmc Struct.Biol., 13, 2013
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2CI7
 | | Crystal structure of Dimethylarginine Dimethylaminohydrolase I in complex with Zinc, high pH | | Descriptor: | GLYCINE, NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1, ... | | Authors: | Frey, D, Braun, O, Briand, C, Vasak, M, Grutter, M.G. | | Deposit date: | 2006-03-17 | | Release date: | 2006-05-17 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inhibitors.
Structure, 14, 2006
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1LJV
 | | Bovine Pancreatic Polypeptide Bound to DPC Micelles | | Descriptor: | PANCREATIC HORMONE | | Authors: | Lerch, M, Gafner, V, Bader, R, Christen, B, Zerbe, O. | | Deposit date: | 2002-04-22 | | Release date: | 2002-10-09 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Bovine pancreatic polypeptide (bPP) undergoes significant changes in conformation and dynamics upon binding to DPC micelles.
J.Mol.Biol., 322, 2002
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4KZ3
 | | Crystal structure of AmpC beta-lactamase in complex with fragment 44 (5-chloro-3-sulfamoylthiophene-2-carboxylic acid) | | Descriptor: | 5-chloro-3-sulfamoylthiophene-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION | | Authors: | Eidam, O, Barelier, S, Fish, I, Shoichet, B.K. | | Deposit date: | 2013-05-29 | | Release date: | 2014-05-21 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Increasing chemical space coverage by combining empirical and computational fragment screens.
Acs Chem.Biol., 9, 2014
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1LOU
 | | RIBOSOMAL PROTEIN S6 | | Descriptor: | RIBOSOMAL PROTEIN S6 | | Authors: | Otzen, D.E, Kristensen, O, Proctor, M, Oliveberg, M. | | Deposit date: | 1998-11-25 | | Release date: | 1998-11-30 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural changes in the transition state of protein folding: alternative interpretations of curved chevron plots.
Biochemistry, 38, 1999
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2CI6
 | | Crystal Structure of Dimethylarginine dimethylaminohydrolase I bound with Zinc low pH | | Descriptor: | NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1, ZINC ION | | Authors: | Frey, D, Braun, O, Briand, C, Vasak, M, Grutter, M.G. | | Deposit date: | 2006-03-17 | | Release date: | 2006-05-17 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inbitors
Structure, 14, 2006
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1L5H
 | | FeMo-cofactor Deficient Nitrogenase MoFe Protein | | Descriptor: | CALCIUM ION, FE(8)-S(7) CLUSTER, nitrogenase molybdenum-iron protein alpha chain, ... | | Authors: | Schmid, B, Ribbe, M.W, Einsle, O, Yoshida, M, Thomas, L.M, Dean, D.R, Rees, D.C, Burgess, B.K. | | Deposit date: | 2002-03-06 | | Release date: | 2002-04-17 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of a cofactor-deficient nitrogenase MoFe protein.
Science, 296, 2002
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2CAY
 | | Vps36 N-terminal PH domain | | Descriptor: | SULFATE ION, VACUOLAR PROTEIN SORTING PROTEIN 36 | | Authors: | Teo, H, Williams, R.L, Perisic, O, Gill, D.J. | | Deposit date: | 2005-12-23 | | Release date: | 2006-04-07 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Escrt-I Core and Escrt-II Glue Domain Structures Reveal Role for Glue in Linking to Escrt-I and Membranes.
Cell(Cambridge,Mass.), 125, 2006
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4IJ0
 | | Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation | | Descriptor: | 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DNA (5'-D(*CP*GP*CP*(C6G)P*AP*AP*TP*TP*CP*GP*CP*G)-3'), STRONTIUM ION | | Authors: | Zhang, F, Suzuki, K, Tsunoda, M, Wilkinson, O, Millington, C.L, Williams, D.M, Morishita, E.C, Takenaka, A. | | Deposit date: | 2012-12-20 | | Release date: | 2013-05-08 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations
Nucleic Acids Res., 41, 2013
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2CLS
 | | The crystal structure of the human RND1 GTPase in the active GTP bound state | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RHO-RELATED GTP-BINDING PROTEIN RHO6 | | Authors: | Pike, A.C.W, Yang, X, Colebrook, S, Gileadi, O, Sobott, F, Bray, J, Wen Hwa, L, Marsden, B, Zhao, Y, Schoch, G, Elkins, J, Debreczeni, J.E, Turnbull, A.P, von Delft, F, Arrowsmith, C, Edwards, A, Weigelt, J, Sundstrom, M, Doyle, D. | | Deposit date: | 2006-04-28 | | Release date: | 2006-05-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | The Crystal Structure of the Human Rnd1 Gtpase in the Active GTP Bound State
To be Published
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4ICT
 | | Substrate and reaction specificity of Mycobacterium tuberculosis cytochrome P450 CYP121 | | Descriptor: | (3S,6S)-3-benzyl-6-(4-hydroxybenzyl)piperazine-2,5-dione, Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Fonvielle, M, Le Du, M.-H, Lequin, O, Lecoq, A, Jacquet, M, Thai, R, Dubois, S, Grach, G, Gondry, M, Belin, P. | | Deposit date: | 2012-12-11 | | Release date: | 2013-05-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Substrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURES.
J.Biol.Chem., 288, 2013
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4IKV
 | | Crystal structure of peptide transporter POT | | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Di-tripeptide ABC transporter (Permease), OLEIC ACID, ... | | Authors: | Doki, S, Kato, H.E, Ishitani, R, Nureki, O. | | Deposit date: | 2012-12-28 | | Release date: | 2013-07-10 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT.
Proc.Natl.Acad.Sci.USA, 110, 2013
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2ASJ
 | | oxoG-modified Preinsertion Binary Complex | | Descriptor: | 5'-D(*CP*TP*AP*AP*CP*(8OG)*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', CALCIUM ION, ... | | Authors: | Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J. | | Deposit date: | 2005-08-23 | | Release date: | 2006-01-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
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2AUV
 | | Solution Structure of HndAc : A Thioredoxin-like [2Fe-2S] Ferredoxin Involved in the NADP-reducing Hydrogenase Complex | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, potential NAD-reducing hydrogenase subunit | | Authors: | Nouailler, M, Morelli, X, Bornet, O, Chetrit, B, Dermoun, Z, Guerlesquin, F. | | Deposit date: | 2005-08-29 | | Release date: | 2006-06-27 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of HndAc: a thioredoxin-like domain involved in the NADP-reducing hydrogenase complex
Protein Sci., 15, 2006
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1OCA
 | | HUMAN CYCLOPHILIN A, UNLIGATED, NMR, 20 STRUCTURES | | Descriptor: | CYCLOPHILIN A | | Authors: | Ottiger, M, Zerbe, O, Guntert, P, Wuthrich, K. | | Deposit date: | 1997-07-07 | | Release date: | 1997-11-19 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The NMR solution conformation of unligated human cyclophilin A.
J.Mol.Biol., 272, 1997
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2B76
 | | E. coli Quinol fumarate reductase FrdA E49Q mutation | | Descriptor: | CITRATE ANION, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | | Authors: | Maklashina, E, Iverson, T.M, Sher, Y, Kotlyar, V, Mirza, O, Andrell, J, Hudson, J.M, Armstrong, F.A, Cecchini, G. | | Deposit date: | 2005-10-03 | | Release date: | 2006-02-21 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Fumarate Reductase and Succinate Oxidase Activity of Escherichia coli Complex II Homologs Are Perturbed Differently by Mutation of the Flavin Binding Domain
J.Biol.Chem., 281, 2006
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4L7C
 | | Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione | | Descriptor: | 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione, ACETATE ION, Kelch-like ECH-associated protein 1 | | Authors: | Jnoff, E, Brookfield, F, Albrecht, C, Barker, J.J, Barker, O, Beaumont, E, Bromidge, S, Brooks, M, Ceska, T, Courade, J.P, Crabbe, T, Duclos, S, Fryatt, T, Jigorel, E, Kwong, J, Sands, Z, Smith, M.A. | | Deposit date: | 2013-06-13 | | Release date: | 2014-02-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex.
Chemmedchem, 9, 2014
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