6A22
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![BU of 6a22 by Molmil](/molmil-images/mine/6a22) | Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T. | 分子名称: | 2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 | 著者 | Noguchi, M, Nomura, A, Doi, S, Yamaguchi, K, Adachi, T. | 登録日 | 2018-06-08 | 公開日 | 2018-12-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction Sci Rep, 8, 2018
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5X8U
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![BU of 5x8u by Molmil](/molmil-images/mine/5x8u) | Crystal Structure of the wild Human ROR gamma Ligand Binding Domain. | 分子名称: | Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1 | 著者 | Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T. | 登録日 | 2017-03-03 | 公開日 | 2017-06-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment Genes Cells, 22, 2017
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5X8Q
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![BU of 5x8q by Molmil](/molmil-images/mine/5x8q) | Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin. | 分子名称: | (1R,2S,4S,5'R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-10,16-diol, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 | 著者 | Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T. | 登録日 | 2017-03-03 | 公開日 | 2017-06-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment Genes Cells, 22, 2017
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5X8W
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![BU of 5x8w by Molmil](/molmil-images/mine/5x8w) | Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain. | 分子名称: | Nuclear receptor ROR-gamma, Nuclear receptor coactivator 1 | 著者 | Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T. | 登録日 | 2017-03-03 | 公開日 | 2017-06-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment Genes Cells, 22, 2017
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5X8X
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![BU of 5x8x by Molmil](/molmil-images/mine/5x8x) | Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A. | 分子名称: | (3R,4R)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-1-ethanoyl-pyrrolidine-3-carboxamide, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 | 著者 | Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T. | 登録日 | 2017-03-03 | 公開日 | 2017-06-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment Genes Cells, 22, 2017
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5X8S
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![BU of 5x8s by Molmil](/molmil-images/mine/5x8s) | Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Ursolic acid. | 分子名称: | Nuclear receptor ROR-gamma, Ursolic acid | 著者 | Noguchi, M, Nomura, A, Murase, K, Doi, S, Yamaguchi, K, Adachi, T. | 登録日 | 2017-03-03 | 公開日 | 2017-06-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment Genes Cells, 22, 2017
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5AYG
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![BU of 5ayg by Molmil](/molmil-images/mine/5ayg) | Crystal Structure of the Human ROR gamma Ligand Binding Domain With 3g | 分子名称: | 3-[5-(2-cyclohexylethyl)-4-ethyl-1,2,4-triazol-3-yl]-N-naphthalen-1-yl-propanamide, Nuclear receptor ROR-gamma | 著者 | Noguchi, M, Doi, S, Nomura, A, Kikuwaka, M, Murase, K, Hirata, K, Kamada, M, Adachi, T. | 登録日 | 2015-08-20 | 公開日 | 2016-03-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor Acs Med.Chem.Lett., 7, 2016
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6IVX
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![BU of 6ivx by Molmil](/molmil-images/mine/6ivx) | Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. | 分子名称: | (4S)-4-[4'-cyclopropyl-5-(2,2-dimethylpropyl)[3,5'-bi-1,2-oxazol]-3'-yl]-6-[(2,4-dichlorophenyl)amino]-6-oxohexanoic acid, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 | 著者 | Noguchi, M, Nomura, A, Doi, S, Adachi, T. | 登録日 | 2018-12-04 | 公開日 | 2019-03-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. J. Med. Chem., 62, 2019
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1DVE
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![BU of 1dve by Molmil](/molmil-images/mine/1dve) | CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME | 分子名称: | HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sugishima, M, Omata, Y, Kakuta, Y, Sakamoto, H, Noguchi, M, Fukuyama, K. | 登録日 | 2000-01-20 | 公開日 | 2000-04-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of rat heme oxygenase-1 in complex with heme. FEBS Lett., 471, 2000
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1IRM
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![BU of 1irm by Molmil](/molmil-images/mine/1irm) | Crystal structure of apo heme oxygenase-1 | 分子名称: | apo heme oxygenase-1 | 著者 | Sugishima, M, Sakamoto, H, Kakuta, Y, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | 登録日 | 2001-10-09 | 公開日 | 2002-07-10 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms Biochemistry, 41, 2002
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1DVG
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![BU of 1dvg by Molmil](/molmil-images/mine/1dvg) | CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME; SELELENO-METHIONINE DERIVATIVE, MUTATED AT M51T,M93L,M155L,M191L. | 分子名称: | HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sugishima, M, Omata, Y, Kakuta, Y, Sakamoto, H, Noguchi, M, Fukuyama, K. | 登録日 | 2000-01-20 | 公開日 | 2000-04-12 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of rat heme oxygenase-1 in complex with heme. FEBS Lett., 471, 2000
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1IX3
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![BU of 1ix3 by Molmil](/molmil-images/mine/1ix3) | Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Cyanide | 分子名称: | CYANIDE ION, HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | 登録日 | 2002-06-10 | 公開日 | 2003-09-02 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1. Biochemistry, 42, 2003
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1IX4
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![BU of 1ix4 by Molmil](/molmil-images/mine/1ix4) | Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Carbon Monoxide | 分子名称: | CARBON MONOXIDE, HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | 登録日 | 2002-06-10 | 公開日 | 2003-09-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1. Biochemistry, 42, 2003
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1P6S
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![BU of 1p6s by Molmil](/molmil-images/mine/1p6s) | Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt) | 分子名称: | RAC-beta serine/threonine protein kinase | 著者 | Auguin, D, Barthe, P, Auge-Senegas, M.T, Stern, M.H, Noguchi, M, Roumestand, C. | 登録日 | 2003-04-30 | 公開日 | 2004-05-18 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and backbone dynamics of the pleckstrin homology domain of the human
protein kinase B (PKB/Akt). Interaction with inositol phosphates. J.BIOMOL.NMR, 28, 2004
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1J2C
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![BU of 1j2c by Molmil](/molmil-images/mine/1j2c) | Crystal structure of rat heme oxygenase-1 in complex with biliverdin IXalpha-iron cluster | 分子名称: | BILIVERDINE IX ALPHA, FE (III) ION, Heme Oxygenase-1 | 著者 | Sugishima, M, Sakamoto, H, Noguchi, M, Fukuyama, K. | 登録日 | 2002-12-29 | 公開日 | 2003-09-02 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of Rat Heme Oxygenase-1 in Complex with Biliverdin-Iron Chelate: CONFORMATIONAL CHANGE OF THE DISTAL HELIX DURING THE HEME CLEAVAGE REACTION. J.Biol.Chem., 278, 2003
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4G7L
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![BU of 4g7l by Molmil](/molmil-images/mine/4g7l) | Crystal Structure of rat Heme oxygenase-1 in complex with Heme and O2 | 分子名称: | FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ... | 著者 | Sugishima, M, Moffat, K, Noguchi, M. | 登録日 | 2012-07-20 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G99
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![BU of 4g99 by Molmil](/molmil-images/mine/4g99) | Rat Heme Oxygenase-1 in complex with Heme and CO at 100 K after warming to 160 K | 分子名称: | CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... | 著者 | Sugishima, M, Moffat, K, Noguchi, M. | 登録日 | 2012-07-23 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G8W
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![BU of 4g8w by Molmil](/molmil-images/mine/4g8w) | Rat Heme Oxygenase-1 in complex with Heme and O2 with 13 hr illumination: Laser on | 分子名称: | FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ... | 著者 | Sugishima, M, Moffat, K, Noguchi, M. | 登録日 | 2012-07-23 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G98
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![BU of 4g98 by Molmil](/molmil-images/mine/4g98) | Rat Heme Oxygenase-1 in complex with Heme and CO at 100K | 分子名称: | CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... | 著者 | Sugishima, M, Moffat, K, Noguchi, M. | 登録日 | 2012-07-23 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G7T
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![BU of 4g7t by Molmil](/molmil-images/mine/4g7t) | Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination: Laser on | 分子名称: | CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... | 著者 | Sugishima, M, Moffat, K, Noguchi, M. | 登録日 | 2012-07-20 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G8U
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![BU of 4g8u by Molmil](/molmil-images/mine/4g8u) | Rat Heme Oxygenase-1 in complex with Heme and O2 with 13 hr illumination: Laser off | 分子名称: | FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ... | 著者 | Sugishima, M, Moffat, K, Noguchi, M. | 登録日 | 2012-07-23 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G7P
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![BU of 4g7p by Molmil](/molmil-images/mine/4g7p) | Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination at 100 K: Laser off | 分子名称: | CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... | 著者 | Sugishima, M, Moffat, K, Noguchi, M. | 登録日 | 2012-07-20 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G8P
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![BU of 4g8p by Molmil](/molmil-images/mine/4g8p) | Rat Heme Oxygenase-1 in complex with Heme and CO with 16 hr Illumination: Laser on | 分子名称: | CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... | 著者 | Sugishima, M, Moffat, K, Noguchi, M. | 登録日 | 2012-07-23 | 公開日 | 2012-10-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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4G7U
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![BU of 4g7u by Molmil](/molmil-images/mine/4g7u) | Rat Heme Oxygenase-1 in complex with Heme and CO with 16 hr Illumination: Laser off | 分子名称: | CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... | 著者 | Sugishima, M, Moffat, K, Noguchi, M. | 登録日 | 2012-07-20 | 公開日 | 2012-10-31 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
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1IVJ
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![BU of 1ivj by Molmil](/molmil-images/mine/1ivj) | Crystal Structure of Rat Hemeoxygenase-1 in Complex with Heme and Azide. | 分子名称: | AZIDE ION, Hemeoxygenase-1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | 登録日 | 2002-03-18 | 公開日 | 2002-12-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal Structure of Rat Heme Oxygenase-1 in Complex with Heme Bound to Azide. IMPLICATION FOR REGIOSPECIFIC HYDROXYLATION OF HEME AT THE alpha -MESO CARBON J.Biol.Chem., 277, 2002
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