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PDB: 66 results

2NP8
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BU of 2np8 by Molmil
Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
Descriptor: N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE, SULFATE ION, Serine/threonine-protein kinase 6
Authors:Tari, L.W, Hoffman, I.D, Bensen, D.C, Hunter, M.J, Nix, J, Nelson, K.J, McRee, D.E, Swanson, R.V.
Deposit date:2006-10-26
Release date:2006-12-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
5F16
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BU of 5f16 by Molmil
CTA-modified hen egg-white lysozyme
Descriptor: CHLORIDE ION, Lysozyme C, SODIUM ION
Authors:McGlone, C, Nix, J.C, Page, R.C.
Deposit date:2015-11-30
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Investigating the Impact of Polymer Functional Groups on the Stability and Activity of Lysozyme-Polymer Conjugates.
Biomacromolecules, 17, 2016
5F14
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BU of 5f14 by Molmil
Structure of native hen egg-white lysozyme
Descriptor: CHLORIDE ION, Lysozyme C, SODIUM ION
Authors:McGlone, C, Nix, J.C, Page, R.C.
Deposit date:2015-11-30
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.148 Å)
Cite:Investigating the Impact of Polymer Functional Groups on the Stability and Activity of Lysozyme-Polymer Conjugates.
Biomacromolecules, 17, 2016
6MJ0
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BU of 6mj0 by Molmil
Crystal structure of the complete turnip yellow mosaic virus 3'UTR
Descriptor: RNA (101-MER)
Authors:Hartwick, E.W, Costantino, D.A, MacFadden, A, Nix, J.C, Tian, S, Das, R, Kieft, J.S.
Deposit date:2018-09-20
Release date:2019-01-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels.
Nat Commun, 9, 2018
3CQX
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BU of 3cqx by Molmil
Chaperone Complex
Descriptor: BAG family molecular chaperone regulator 2, Heat shock cognate 71 kDa protein, SODIUM ION, ...
Authors:Xu, Z, Nix, J.C, Misra, S.
Deposit date:2008-04-03
Release date:2008-11-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2
Nat.Struct.Mol.Biol., 15, 2008
5TPY
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BU of 5tpy by Molmil
Crystal structure of an exonuclease resistant RNA from Zika virus
Descriptor: HEXANE-1,6-DIOL, MAGNESIUM ION, RNA (71-MER)
Authors:Akiyama, B.M, Laurence, H.M, Massey, A.R, Costantino, D.A, Xie, X, Yang, Y, Shi, P.-Y, Nix, J.C, Beckham, J.D, Kieft, J.S.
Deposit date:2016-10-21
Release date:2016-12-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.
Science, 354, 2016
7JJU
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BU of 7jju by Molmil
Crystal structure of en exoribonuclease-resistant RNA (xrRNA) from Potato leafroll virus (PLRV)
Descriptor: CACODYLATE ION, Guanidinium, IRIDIUM HEXAMMINE ION, ...
Authors:Steckelberg, A.-L, Vicens, Q, Auffinger, P, Costantino, D.C, Nix, J.C, Kieft, J.S.
Deposit date:2020-07-27
Release date:2020-09-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold.
Rna, 26, 2020
3D0T
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BU of 3d0t by Molmil
Structure of the BNB domain of the Hsp70 cochaperone Bag2
Descriptor: BAG family molecular chaperone regulator 2
Authors:Xu, Z, Nix, J.C, Devlin, K, Misra, S.
Deposit date:2008-05-02
Release date:2008-11-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2.
Nat.Struct.Mol.Biol., 15, 2008
6OP6
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BU of 6op6 by Molmil
Structure of VIM-20 in the reduced state
Descriptor: Metallo-beta-lactamase VIM-20, SODIUM ION, ZINC ION
Authors:Page, R.C, Shurina, B.A, Montgomery, J.S, Orischak, M.G, Nix, J.C.
Deposit date:2019-04-24
Release date:2019-10-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions.
Mbio, 10, 2019
7RNJ
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BU of 7rnj by Molmil
S2P6 Fab fragment bound to the SARS-CoV/SARS-CoV-2 spike stem helix peptide
Descriptor: Monoclonal antibody S2P6 Fab heavy chain, Monoclonal antibody S2P6 Fab light chain, SULFATE ION, ...
Authors:Snell, G, Czudnochowski, N, Croll, T.I, Nix, J.C, Corti, D, Cameroni, E, Pinto, D, Beltramello, M, Sauer, M.M, Veesler, D.
Deposit date:2021-07-29
Release date:2021-08-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Broad betacoronavirus neutralization by a stem helix-specific human antibody.
Science, 373, 2021
6OP7
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BU of 6op7 by Molmil
Structure of oxidized VIM-20
Descriptor: ACETATE ION, Metallo-beta-lactamase VIM-20, ZINC ION
Authors:Page, R.C, Shurina, B.A, Montgomery, J.S, Orischak, M.G, Nix, J.C.
Deposit date:2019-04-24
Release date:2019-10-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions.
Mbio, 10, 2019
5J9A
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BU of 5j9a by Molmil
Ambient temperature transition state structure of arginine kinase - crystal 11/Form II
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ARGININE, Arginine kinase, ...
Authors:Godsey, M, Davulcu, O, Nix, J, Skalicky, J.J, Bruschweiler, R, Chapman, M.S.
Deposit date:2016-04-08
Release date:2016-08-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase.
Structure, 24, 2016
5J99
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BU of 5j99 by Molmil
Ambient temperature transition state structure of arginine kinase - crystal 8/Form I
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ARGININE, Arginine kinase, ...
Authors:Godsey, M, Davulcu, O, Nix, J, Skalicky, J.J, Bruschweiler, R, Chapman, M.S.
Deposit date:2016-04-08
Release date:2016-08-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase.
Structure, 24, 2016
6NHK
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BU of 6nhk by Molmil
Mortalin nucleotide binding domain in the ADP-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Page, R.C, Moseng, M.A, Nix, J.C.
Deposit date:2018-12-23
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.777 Å)
Cite:Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.
J.Phys.Chem.B, 123, 2019
2OXQ
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BU of 2oxq by Molmil
Structure of the UbcH5 :CHIP U-box complex
Descriptor: CHLORIDE ION, STIP1 homology and U-Box containing protein 1, Ubiquitin-conjugating enzyme E2D 1
Authors:Xu, Z, Nix, J.C, Devlin, K.I, Misra, S.
Deposit date:2007-02-20
Release date:2008-02-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes.
Bmc Struct.Biol., 8, 2008
5GYJ
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BU of 5gyj by Molmil
Structure of catalytically active sortase from Clostridium difficile
Descriptor: Putative peptidase C60B, sortase B
Authors:Yin, J.-C, Fei, C.-H, Hsiao, Y.-Y, Nix, J.C, Huang, I.-H, Wang, S.
Deposit date:2016-09-22
Release date:2017-01-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural Insights into Substrate Recognition by Clostridium difficile Sortase.
Front Cell Infect Microbiol, 6, 2016
6CDX
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BU of 6cdx by Molmil
High-resolution crystal structure of fluoropropylated cystine knot, binding to alpha-5 beta-6 integrin
Descriptor: cystine knot (fluoropropylated)
Authors:Kimura, R, Nix, J, Bongura, C, Chakraborti, S, Gambhir, S, Filipp, F.V.
Deposit date:2018-02-09
Release date:2019-08-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1 Å)
Cite:Evaluation of integrin alpha v beta6cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis.
Nat Commun, 10, 2019
6D3P
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BU of 6d3p by Molmil
Crystal structure of an exoribonuclease-resistant RNA from Sweet clover necrotic mosaic virus (SCNMV)
Descriptor: IRIDIUM HEXAMMINE ION, RNA (45-MER)
Authors:Steckelberg, A.-L, Akiyama, B.M, Costantino, D.A, Sit, T.L, Nix, J.C, Kieft, J.S.
Deposit date:2018-04-16
Release date:2018-06-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A folded viral noncoding RNA blocks host cell exoribonucleases through a conformationally dynamic RNA structure.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5EMT
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BU of 5emt by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)-copper complex
Descriptor: COPPER (II) ION, Histidine triad nucleotide-binding protein 1
Authors:Maize, K.M, Nix, J.C, Finzel, B.C.
Deposit date:2015-11-06
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain.
Biochem. Biophys. Res. Commun., 491, 2017
2Q5G
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BU of 2q5g by Molmil
Ligand binding domain of PPAR delta receptor in complex with a partial agonist
Descriptor: Peroxisome proliferator-activated receptor delta, [(7-{[2-(3-MORPHOLIN-4-YLPROP-1-YN-1-YL)-6-{[4-(TRIFLUOROMETHYL)PHENYL]ETHYNYL}PYRIDIN-4-YL]THIO}-2,3-DIHYDRO-1H-INDEN- 4-YL)OXY]ACETIC ACID
Authors:Pettersson, I, Sauerberg, P, Johansson, E, Hoffman, I, Tari, L.W, Hunter, M.J, Nix, J.
Deposit date:2007-06-01
Release date:2008-06-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of a partial PPARdelta agonist.
Bioorg.Med.Chem.Lett., 17, 2007
3QIL
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BU of 3qil by Molmil
Crystal structure analysis of the clathrin trimerization domain
Descriptor: Clathrin heavy chain 1
Authors:Ybe, J.A, Mishra, S, Nix, J.
Deposit date:2011-01-27
Release date:2012-02-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Nuclear localization of clathrin involves a labile helix outside the trimerization domain.
Febs Lett., 587, 2013
3L27
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BU of 3l27 by Molmil
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain R312A mutant
Descriptor: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ...
Authors:Leung, D.W, Prins, K.C, Borek, D.M, Farahbakhsh, M, Tufariello, J.M, Ramanan, P, Nix, J.C, Helgeson, L.A, Otwinowski, Z, Honzatko, R.B, Basler, C.F, Amarasinghe, G.K.
Deposit date:2009-12-14
Release date:2010-01-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Nat.Struct.Mol.Biol., 17, 2010
3L26
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BU of 3l26 by Molmil
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA
Descriptor: CHLORIDE ION, MAGNESIUM ION, Polymerase cofactor VP35, ...
Authors:Leung, D.W, Prins, K.C, Borek, D.M, Farahbakhsh, M, Tufariello, J.M, Ramanan, P, Nix, J.C, Helgeson, L.A, Otwinowski, Z, Honzatko, R.B, Basler, C.F, Amarasinghe, G.K.
Deposit date:2009-12-14
Release date:2010-01-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Nat.Struct.Mol.Biol., 17, 2010
3L28
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BU of 3l28 by Molmil
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain K339A mutant
Descriptor: CHLORIDE ION, Polymerase cofactor VP35, SODIUM ION, ...
Authors:Leung, D.W, Prins, K.C, Borek, D.M, Farahbakhsh, M, Tufariello, J.M, Ramanan, P, Nix, J.C, Helgeson, L.A, Otwinowski, Z, Honzatko, R.B, Basler, C.F, Amarasinghe, G.K.
Deposit date:2009-12-14
Release date:2010-01-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Nat.Struct.Mol.Biol., 17, 2010
3L25
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BU of 3l25 by Molmil
Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA
Descriptor: CHLORIDE ION, FORMIC ACID, GLYCEROL, ...
Authors:Leung, D.W, Prins, K.C, Borek, D.M, Farahbakhsh, M, Tufariello, J.M, Ramanan, P, Nix, J.C, Helgeson, L.A, Otwinowski, Z, Honzatko, R.B, Basler, C.F, Amarasinghe, G.K.
Deposit date:2009-12-14
Release date:2010-01-26
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.
Nat.Struct.Mol.Biol., 17, 2010

221371

数据于2024-06-19公开中

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