7TA6
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![BU of 7ta6 by Molmil](/molmil-images/mine/7ta6) | Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural alpha/beta-peptide-1 | Descriptor: | 1,2-ETHANEDIOL, AMINO GROUP, Alpha/Beta-peptide-1, ... | Authors: | Niu, J, Bingman, C.A, Gellman, S.H. | Deposit date: | 2021-12-20 | Release date: | 2022-06-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling. J.Am.Chem.Soc., 144, 2022
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7TA3
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![BU of 7ta3 by Molmil](/molmil-images/mine/7ta3) | |
8GPJ
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![BU of 8gpj by Molmil](/molmil-images/mine/8gpj) | HIV-1 Env X16 UFO in complex with 8ANC195 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8ANC195 Fab heavy chain, ... | Authors: | Niu, J, Xu, Y.W, Yang, B. | Deposit date: | 2022-08-26 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs. Nat Commun, 14, 2023
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8GPI
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![BU of 8gpi by Molmil](/molmil-images/mine/8gpi) | HIV-1 Env X18 UFO in complex with 8ANC195 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8ANC195 Fab heavy chain, ... | Authors: | Niu, J, Xu, Y.W, Yang, B. | Deposit date: | 2022-08-26 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs. Nat Commun, 14, 2023
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8GP5
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![BU of 8gp5 by Molmil](/molmil-images/mine/8gp5) | Structure of X18 UFO protomer in complex with F6 Fab VHVL domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, F6 Fab VH domain, ... | Authors: | Niu, J, Xu, Y.W, Yang, B. | Deposit date: | 2022-08-25 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs. Nat Commun, 14, 2023
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8GPG
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![BU of 8gpg by Molmil](/molmil-images/mine/8gpg) | HIV-1 Env X18 UFO in complex with F6 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, F6 Fab heavy chain, ... | Authors: | Niu, J, Xu, Y.W, Yang, B. | Deposit date: | 2022-08-26 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs. Nat Commun, 14, 2023
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8GPK
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![BU of 8gpk by Molmil](/molmil-images/mine/8gpk) | |
7V8Q
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![BU of 7v8q by Molmil](/molmil-images/mine/7v8q) | Crystal structure of antibody 14A in complex with MUC1 Glycopeptide(GlycoT) | Descriptor: | 14A fab heavy chain, 14A fab light chain, 2-acetamido-2-deoxy-beta-D-galactopyranose, ... | Authors: | Niu, J, Xu, L, Meng, B, Han, Y.B, Yang, B. | Deposit date: | 2021-08-23 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding To Be Published
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7VAC
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![BU of 7vac by Molmil](/molmil-images/mine/7vac) | Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoST) | Descriptor: | 14A fab heavy chain, 14A fab light chain, 2-acetamido-2-deoxy-beta-D-galactopyranose, ... | Authors: | Niu, J, Xu, L, Meng, B, Han, Y.B, Yang, B. | Deposit date: | 2021-08-28 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding To Be Published
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7VAZ
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![BU of 7vaz by Molmil](/molmil-images/mine/7vaz) | Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoS) | Descriptor: | 14A fab heavy chain, 14A fab light chain, 2-acetamido-2-deoxy-beta-D-galactopyranose, ... | Authors: | Niu, J, Xu, L, Meng, B, Han, Y.B, Yang, B. | Deposit date: | 2021-08-30 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding To Be Published
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7V64
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![BU of 7v64 by Molmil](/molmil-images/mine/7v64) | Crystal structure of Antibody 16A in complex with MUC1 Glycopeptide(GlycoT) | Descriptor: | 16A fab Heavy chain, 16A fab Light chain, 2-acetamido-2-deoxy-beta-D-galactopyranose, ... | Authors: | Niu, J, Xu, L, Meng, B, Han, Y.B, Yang, B. | Deposit date: | 2021-08-19 | Release date: | 2022-08-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding To Be Published
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7V7K
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![BU of 7v7k by Molmil](/molmil-images/mine/7v7k) | Crystal structure of Antibody 16A in complex with MUC1 Glycopeptide(GlycoST) | Descriptor: | 16A fab heavy chain, 16A fab light chain, 2-acetamido-2-deoxy-beta-D-galactopyranose, ... | Authors: | Niu, J, Xu, L, Meng, B, Han, Y.B, Yang, B. | Deposit date: | 2021-08-21 | Release date: | 2022-08-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding To Be Published
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7V3Q
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![BU of 7v3q by Molmil](/molmil-images/mine/7v3q) | Crystal structure of anti-MUC1 antibody 16A | Descriptor: | Fab 16A Heavy Chain, Fab 16A Light Chain | Authors: | Niu, J, Xu, L, Meng, B, Han, Y.B, Yang, B. | Deposit date: | 2021-08-11 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding To Be Published
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7V4W
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![BU of 7v4w by Molmil](/molmil-images/mine/7v4w) | Crystal structure of Antibody 16A in complex with MUC1 peptide | Descriptor: | 16A Fab Heavy chain, 16A Fab Light chain, Mucin-1 subunit alpha | Authors: | Niu, J, Xu, L, Meng, B, Han, Y.B, Yang, B. | Deposit date: | 2021-08-15 | Release date: | 2022-08-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding To Be Published
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1PPD
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![BU of 1ppd by Molmil](/molmil-images/mine/1ppd) | |
1VS0
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![BU of 1vs0 by Molmil](/molmil-images/mine/1vs0) | Crystal Structure of the Ligase Domain from M. tuberculosis LigD at 2.4A | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Putative DNA ligase-like protein Rv0938/MT0965, ... | Authors: | Akey, D, Martins, A, Aniukwu, J, Glickman, M.S, Shuman, S, Berger, J.M, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2006-01-27 | Release date: | 2006-02-28 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure and Nonhomologous End-joining Function of the Ligase Component of Mycobacterium DNA Ligase D. J.Biol.Chem., 281, 2006
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1MAP
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![BU of 1map by Molmil](/molmil-images/mine/1map) | |
1MAQ
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![BU of 1maq by Molmil](/molmil-images/mine/1maq) | |
9AAT
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![BU of 9aat by Molmil](/molmil-images/mine/9aat) | |
7AAT
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![BU of 7aat by Molmil](/molmil-images/mine/7aat) | |
8AAT
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![BU of 8aat by Molmil](/molmil-images/mine/8aat) | |
4AN2
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![BU of 4an2 by Molmil](/molmil-images/mine/4an2) | Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. | Descriptor: | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Rice, K.D, Aay, N, Anand, N.K, Blazey, C.M, Bowles, O.J, Bussenius, J, Costanzo, S, Curtis, J.K, Defina, S.C, Dubenko, L, Engst, S, Joshi, A.A, Kennedy, A.R, Kim, A.I, Koltun, E.S, Lougheed, J.C, Manalo, J.C.L, Martini, J.F, Nuss, J.M, Peto, C.J, Tsang, T.H, Yu, P, Johnston, S. | Deposit date: | 2012-03-14 | Release date: | 2012-12-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward Xl518 (Gdc-0973) Acs Med.Chem.Lett., 3, 2012
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4ANB
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![BU of 4anb by Molmil](/molmil-images/mine/4anb) | Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. | Descriptor: | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Rice, K.D, Aay, N, Anand, N.K, Blazey, C.M, Bowles, O.J, Bussenius, J, Costanzo, S, Curtis, J.K, Defina, S.C, Dubenko, L, Engst, S, Joshi, A.A, Kennedy, A.R, Kim, A.I, Koltun, E.S, Lougheed, J.C, Manalo, J.C.L, Martini, J.F, Nuss, J.M, Peto, C.J, Tsang, T.H, Yu, P, Johnston, S. | Deposit date: | 2012-03-16 | Release date: | 2012-12-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward Xl518 (Gdc-0973) Acs Med.Chem.Lett., 3, 2012
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4AN3
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![BU of 4an3 by Molmil](/molmil-images/mine/4an3) | Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAGNESIUM ION, ... | Authors: | Rice, K.D, Aay, N, Anand, N.K, Blazey, C.M, Bowles, O.J, Bussenius, J, Costanzo, S, Curtis, J.K, Defina, S.C, Dubenko, L, Engst, S, Joshi, A.A, Kennedy, A.R, Kim, A.I, Koltun, E.S, Lougheed, J.C, Manalo, J.C.L, Martini, J.F, Nuss, J.M, Peto, C.J, Tsang, T.H, Yu, P, Johnston, S. | Deposit date: | 2012-03-15 | Release date: | 2012-12-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward Xl518 (Gdc-0973) Acs Med.Chem.Lett., 3, 2012
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4AN9
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![BU of 4an9 by Molmil](/molmil-images/mine/4an9) | Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs. | Descriptor: | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Rice, K.D, Aay, N, Anand, N.K, Blazey, C.M, Bowles, O.J, Bussenius, J, Costanzo, S, Curtis, J.K, Defina, S.C, Dubenko, L, Engst, S, Joshi, A.A, Kennedy, A.R, Kim, A.I, Koltun, E.S, Lougheed, J.C, Manalo, J.C.L, Martini, J.F, Nuss, J.M, Peto, C.J, Tsang, T.H, Yu, P, Johnston, S. | Deposit date: | 2012-03-16 | Release date: | 2012-12-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Novel Carboxamide-Based Allosteric Mek Inhibitors: Discovery and Optimization Efforts Toward Xl518 (Gdc-0973) Acs Med.Chem.Lett., 3, 2012
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