4LCU
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![BU of 4lcu by Molmil](/molmil-images/mine/4lcu) | Structure of KcsA with E118A mutation | Descriptor: | DIACYL GLYCEROL, Fab heavy chain, Fab light chain, ... | Authors: | Nimigean, C.M, Posson, D.J, McCoy, J.M. | Deposit date: | 2013-06-23 | Release date: | 2013-10-30 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.752 Å) | Cite: | Molecular interactions involved in proton-dependent gating in KcsA potassium channels. J.Gen.Physiol., 142, 2013
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4LBE
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![BU of 4lbe by Molmil](/molmil-images/mine/4lbe) | Structure of KcsA with R122A mutation | Descriptor: | DIACYL GLYCEROL, Fab heavy chain, Fab light chain, ... | Authors: | Nimigean, C.M, Posson, D.J, McCoy, J.M. | Deposit date: | 2013-06-20 | Release date: | 2013-10-30 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.751 Å) | Cite: | Molecular interactions involved in proton-dependent gating in KcsA potassium channels. J.Gen.Physiol., 142, 2013
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6CJU
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![BU of 6cju by Molmil](/molmil-images/mine/6cju) | Structure of the SthK cyclic nucleotide-gated potassium channel in complex with cAMP | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK cyclic nucleotide-gated potassium channel | Authors: | Nimigean, C.M, Rheinberger, J. | Deposit date: | 2018-02-26 | Release date: | 2018-08-01 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures. Elife, 7, 2018
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6CJQ
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![BU of 6cjq by Molmil](/molmil-images/mine/6cjq) | Structure of the SthK cyclic nucleotide-gated potassium channel | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, SthK cyclic nucleotide-gated potassium channel | Authors: | Nimigean, C.M, Rheinberger, J. | Deposit date: | 2018-02-26 | Release date: | 2018-08-01 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures. Elife, 7, 2018
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6CJT
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![BU of 6cjt by Molmil](/molmil-images/mine/6cjt) | Structure of the SthK cyclic nucleotide-gated potassium channel in complex with cGMP | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CYCLIC GUANOSINE MONOPHOSPHATE, SthK cyclic nucleotide-gated potassium channel | Authors: | Nimigean, C.M, Rheinberger, J. | Deposit date: | 2018-02-26 | Release date: | 2018-08-01 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures. Elife, 7, 2018
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7RU0
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![BU of 7ru0 by Molmil](/molmil-images/mine/7ru0) | SthK R120A Open State 1 | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C, Schmidpeter, P. | Deposit date: | 2021-08-16 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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7RYR
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![BU of 7ryr by Molmil](/molmil-images/mine/7ryr) | SthK R120A Open State 3 | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C, Schmidpeter, P. | Deposit date: | 2021-08-26 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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6VY0
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![BU of 6vy0 by Molmil](/molmil-images/mine/6vy0) | |
8FZ7
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![BU of 8fz7 by Molmil](/molmil-images/mine/8fz7) | TpeA bound closed MthK-A88F mutant in nanodisc | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1-(tripentyl-$l^{4}-azanyl)pentane, Calcium-gated potassium channel MthK, ... | Authors: | Agarwal, S, Nimigean, C.M. | Deposit date: | 2023-01-27 | Release date: | 2023-10-11 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Calcium-gated potassium channel blockade via membrane-facing fenestrations. Nat.Chem.Biol., 20, 2024
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5E1A
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![BU of 5e1a by Molmil](/molmil-images/mine/5e1a) | Structure of KcsA with L24C/R117C mutations | Descriptor: | POTASSIUM ION, antibody Fab fragment heavy chain, antibody Fab fragment light chain, ... | Authors: | Upadhyay, V, Kim, D.M, Nimigean, C.M. | Deposit date: | 2015-09-29 | Release date: | 2016-07-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles. J.Gen.Physiol., 148, 2016
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3OGC
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![BU of 3ogc by Molmil](/molmil-images/mine/3ogc) | KcsA E71A variant in presence of Na+ | Descriptor: | SODIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ... | Authors: | McCoy, J.G, Nimigean, C.M. | Deposit date: | 2010-08-16 | Release date: | 2011-03-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Mechanism for selectivity-inactivation coupling in KcsA potassium channels. Proc.Natl.Acad.Sci.USA, 108, 2011
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7RTF
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![BU of 7rtf by Molmil](/molmil-images/mine/7rtf) | SthK R120A Closed State | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C. | Deposit date: | 2021-08-13 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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7RTJ
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![BU of 7rtj by Molmil](/molmil-images/mine/7rtj) | SthK Y26F Activated State | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C. | Deposit date: | 2021-08-13 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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7RYS
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![BU of 7rys by Molmil](/molmil-images/mine/7rys) | SthK R120A Open State 2 | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C, Schmidpeter, P. | Deposit date: | 2021-08-26 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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7TJ5
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![BU of 7tj5 by Molmil](/molmil-images/mine/7tj5) | SthK closed state, cAMP-bound in the presence of POPA | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | Authors: | Schmidpeter, P.A, Nimigean, C.M. | Deposit date: | 2022-01-14 | Release date: | 2022-10-26 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nat.Struct.Mol.Biol., 29, 2022
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7TKT
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![BU of 7tkt by Molmil](/molmil-images/mine/7tkt) | SthK closed state, cAMP-bound in the presence of detergent | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | Authors: | Rheinberger, J, Schmidpeter, P.A, Nimigean, C.M. | Deposit date: | 2022-01-17 | Release date: | 2022-10-26 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nat.Struct.Mol.Biol., 29, 2022
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7TJ6
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![BU of 7tj6 by Molmil](/molmil-images/mine/7tj6) | SthK open state, cAMP-bound in the presence of POPA | Descriptor: | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | Authors: | Schmidpeter, P.A, Nimigean, C.M. | Deposit date: | 2022-01-14 | Release date: | 2022-10-26 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nat.Struct.Mol.Biol., 29, 2022
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3GB7
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![BU of 3gb7 by Molmil](/molmil-images/mine/3gb7) | Potassium Channel KcsA-Fab complex in Li+ | Descriptor: | DIACYL GLYCEROL, NICKEL (II) ION, Voltage-gated potassium channel, ... | Authors: | Thompson, A.N, Ilsoo, K, Panosian, T.D, Iverson, T.M, Allen, T.W, Nimigean, C.M. | Deposit date: | 2009-02-18 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nat.Struct.Mol.Biol., 16, 2009
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3IGA
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![BU of 3iga by Molmil](/molmil-images/mine/3iga) | Potassium Channel KcsA-Fab complex in Li+ and K+ | Descriptor: | Antibody Fab Fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | Authors: | Thompson, A.N, Ilsoo, K, Panosian, T.D, Iverson, T.M, Allen, T.W, Nimigean, C.M. | Deposit date: | 2009-07-27 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nat.Struct.Mol.Biol., 16, 2009
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7RSH
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![BU of 7rsh by Molmil](/molmil-images/mine/7rsh) | SthK Y26F Closed State | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SthK | Authors: | Gao, X, Nimigean, C. | Deposit date: | 2021-08-11 | Release date: | 2022-11-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel. Nat Commun, 13, 2022
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8DJB
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![BU of 8djb by Molmil](/molmil-images/mine/8djb) | MthK-A90L mutant in closed state with 0 Ca2+ | Descriptor: | Calcium-gated potassium channel MthK, POTASSIUM ION | Authors: | Agarwal, S, Nimigean, C.M. | Deposit date: | 2022-06-30 | Release date: | 2023-07-05 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.18 Å) | Cite: | Calcium-gated potassium channel blockade via membrane-facing fenestrations. Nat.Chem.Biol., 20, 2024
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4HZ3
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![BU of 4hz3 by Molmil](/molmil-images/mine/4hz3) | MthK pore crystallized in presence of TBSb | Descriptor: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | Authors: | Posson, D.J, McCoy, J.G, Nimigean, C.M. | Deposit date: | 2012-11-14 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter. Nat.Struct.Mol.Biol., 20, 2013
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4HYO
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![BU of 4hyo by Molmil](/molmil-images/mine/4hyo) | Crystal Structure of MthK Pore | Descriptor: | Calcium-gated potassium channel mthK, HEXANE-1,6-DIOL, POTASSIUM ION | Authors: | Posson, D.J, McCoy, J.G, Nimigean, C.M. | Deposit date: | 2012-11-13 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The voltage-dependent gate in MthK potassium channels is located at the selectivity filter. Nat.Struct.Mol.Biol., 20, 2013
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4CHW
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![BU of 4chw by Molmil](/molmil-images/mine/4chw) | The electron crystallography structure of the cAMP-free potassium channel MloK1 | Descriptor: | CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION | Authors: | Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. | Deposit date: | 2013-12-04 | Release date: | 2014-01-15 | Last modified: | 2024-05-08 | Method: | ELECTRON CRYSTALLOGRAPHY (7 Å) | Cite: | Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1. Nat Commun, 5, 2014
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4CHV
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![BU of 4chv by Molmil](/molmil-images/mine/4chv) | The electron crystallography structure of the cAMP-bound potassium channel MloK1 | Descriptor: | CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION | Authors: | Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. | Deposit date: | 2013-12-04 | Release date: | 2014-01-15 | Last modified: | 2024-05-08 | Method: | ELECTRON CRYSTALLOGRAPHY (7 Å) | Cite: | Ligand-Induced Structural Changes in the Cyclic Nucleotide-Modulated Potassium Channel Mlok1 Nat.Commun., 5, 2014
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