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PDB: 17048 件
4V06
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BU of 4v06 by Molmil
Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain
分子名称: FE (III) ION, IMIDAZOLE, TRYPTOPHAN 5-HYDROXYLASE 2
著者Kopec, J, Oberholzer, A, Fitzpatrick, F, Newman, J, Tallant, C, Kiyani, W, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W.
登録日2014-09-11
公開日2014-10-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain
To be Published
4UUZ
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BU of 4uuz by Molmil
MCM2-histone complex
分子名称: DNA REPLICATION LICENSING FACTOR MCM2, HISTONE H3, HISTONE H4
著者Richet, N, Liu, D, Legrand, P, Bakail, M, Compper, C, Besle, A, Guerois, R, Ochsenbein, F.
登録日2014-08-01
公開日2015-02-11
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Insight Into How the Human Helicase Subunit Mcm2 May Act as a Histone Chaperone Together with Asf1 at the Replication Fork.
Nucleic Acids Res., 43, 2015
4UUS
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BU of 4uus by Molmil
CRYSTAL STRUCTURE OF A UBX-EXD-DNA COMPLEX INCLUDING THE UBDA MOTIF
分子名称: 5'-D(*AP*CP*GP*TP*GP*AP*TP*TP*TP*AP*TP*GP*GP*CP*G)-3', 5'-D(*GP*TP*CP*GP*CP*CP*AP*TP*AP*AP*AP*TP*CP*AP*C)-3', HOMEOTIC PROTEIN EXTRADENTICLE, ...
著者Foos, N, Mate, M.J, Ortiz-Lombardia, M.
登録日2014-07-31
公開日2015-02-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献A Flexible Extension of the Drosophila Ultrabithorax Homeodomain Defines a Novel Hox/Pbc Interaction Mode.
Structure, 23, 2015
4UUC
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BU of 4uuc by Molmil
Crystal structure of human ASB11 ankyrin repeat domain
分子名称: ANKYRIN REPEAT AND SOCS BOX PROTEIN 11
著者Pinkas, D.M, Sanvitale, C, Kragh Nielsen, T, Guo, K, Sorrell, F, Berridge, G, Ayinampudi, V, Wang, D, Newman, J.A, Tallant, C, Chaikuad, A, Canning, P, Kopec, J, Krojer, T, Vollmar, M, Allerston, C.K, Chalk, R, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Bullock, A.
登録日2014-07-25
公開日2014-08-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of Human Asb11 Ankyrin Repeat Domain
To be Published
4URO
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BU of 4uro by Molmil
Crystal Structure of Staph GyraseB 24kDa in complex with Novobiocin
分子名称: DNA GYRASE SUBUNIT B, NOVOBIOCIN
著者Lu, J, Patel, S, Sharma, N, Soisson, S, Kishii, R, Takei, M, Fukuda, Y, Lumb, K.J, Singh, S.B.
登録日2014-07-01
公開日2014-07-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Structures of Kibdelomycin Bound to Staphylococcus Aureus Gyrb and Pare Showed a Novel U-Shaped Binding Mode.
Acs Chem.Biol., 9, 2014
4UUT
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BU of 4uut by Molmil
Crystal structure of the Ultrabithorax protein
分子名称: CHLORIDE ION, HOMEOTIC PROTEIN ULTRABITHORAX, SULFATE ION
著者Foos, N, Mate, M.J, Ortiz-Lombardia, M.
登録日2014-07-31
公開日2015-02-18
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献A Flexible Extension of the Drosophila Ultrabithorax Homeodomain Defines a Novel Hox/Pbc Interaction Mode.
Structure, 23, 2015
4UWL
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BU of 4uwl by Molmil
Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
分子名称: (8S)-2-[(3R)-3-methylmorpholin-4-yl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3, SULFATE ION
著者Pasquier, B, El-Ahmad, Y, Filoche-Romme, B, Dureuil, C, Fassy, F, Abecassis, P.Y, Mathieu, M, Bertrand, T, Benard, T, Barriere, C, ElBatti, S, Letallec, J.P, Sonnefraud, V, Brollo, M, Delbarre, L, Loyau, V, Pilorge, F, Bertin, L, Richepin, P, Arigon, J, Labrosse, J.R, Clement, J, Durand, F, Combet, R, Perraut, P, Leroy, V, Gay, F, Lefrancois, D, Bretin, F, Marquette, J.P, Michot, N, Caron, A, Castell, C, Schio, L, McCort, G, Goulaouic, H, Garcia-Echeverria, C, Ronan, B.
登録日2014-08-12
公開日2014-11-26
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.
J.Med.Chem., 58, 2015
4UWK
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BU of 4uwk by Molmil
Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
分子名称: (2S)-1-[(5-chloro-2-thienyl)methyl]-8-[(3R,5R)-3,5-dimethylmorpholin-4-yl]-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one, GLYCEROL, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3, ...
著者Pasquier, B, El-Ahmad, Y, Filoche-Romme, B, Dureuil, C, Fassy, F, Abecassis, P.Y, Mathieu, M, Bertrand, T, Benard, T, Barriere, C, ElBatti, S, Letallec, J.P, Sonnefraud, V, Brollo, M, Delbarre, L, Loyau, V, Pilorge, F, Bertin, L, Richepin, P, Arigon, J, Labrosse, J.R, Clement, J, Durand, F, Combet, R, Perraut, P, Leroy, V, Gay, F, Lefrancois, D, Bretin, F, Marquette, J.P, Michot, N, Caron, A, Castell, C, Schio, L, McCort, G, Goulaouic, H, Garcia-Echeverria, C, Ronan, B.
登録日2014-08-12
公開日2014-11-26
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.
J.Med.Chem., 58, 2015
4UWH
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BU of 4uwh by Molmil
Discovery of (2S)-8-((3R)-3-Methylmorpholin-4-yl)-1-(3-methyl-2-oxo- butyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido(1,2-a)pyrimidin-6- one: a Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors
分子名称: (8S)-9-[(2R)-2-hydroxy-2-phenylethyl]-2-(morpholin-4-yl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3, SODIUM ION
著者Pasquier, B, El-Ahmad, Y, Filoche-Romme, B, Dureuil, C, Fassy, F, Abecassis, P.Y, Mathieu, M, Bertrand, T, Benard, T, Barriere, C, ElBatti, S, Letallec, J.P, Sonnefraud, V, Brollo, M, Delbarre, L, Loyau, V, Pilorge, F, Bertin, L, Richepin, P, Arigon, J, Labrosse, J.R, Clement, J, Durand, F, Combet, R, Perraut, P, Leroy, V, Gay, F, Lefrancois, D, Bretin, F, Marquette, J.P, Michot, N, Caron, A, Castell, C, Schio, L, McCort, G, Goulaouic, H, Garcia-Echeverria, C, Ronan, B.
登録日2014-08-12
公開日2014-11-26
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors.
J.Med.Chem., 58, 2015
1X57
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BU of 1x57 by Molmil
Solution structures of the HTH domain of human EDF-1 protein
分子名称: Endothelial differentiation-related factor 1
著者Nameki, N, Sato, M, Tochio, N, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2005-05-15
公開日2005-11-15
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structures of the HTH domain of human EDF-1 protein
To be Published
6LDT
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BU of 6ldt by Molmil
K245A mutant of L-tyrosine decarboxylase from Methanocaldococcus jannaschii complexed with a post-decarboxylation quinonoid-like intermediate formed with L-tyrosine
分子名称: GLYCEROL, L-tyrosine/L-aspartate decarboxylase, SULFATE ION, ...
著者Manoj, N, Chellam Gayathri, S.
登録日2019-11-23
公開日2020-12-02
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural insights into the mechanism of internal aldimine formation and catalytic loop dynamics in an archaeal Group II decarboxylase.
J.Struct.Biol., 208, 2019
1NN5
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BU of 1nn5 by Molmil
Crystal structure of human thymidylate kinase with d4TMP + AppNHp
分子名称: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
4WG7
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BU of 4wg7 by Molmil
Room-temperature crystal structure of lysozyme determined by serial synchrotron crystallography using a nano focused beam.
分子名称: CHLORIDE ION, Lysozyme C
著者Coquelle, N, Brewster, A.S, Kappe, U, Shilova, A, Weinhausen, B, Burghammer, M, Colletier, J.P.
登録日2014-09-18
公開日2015-05-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Raster-scanning serial protein crystallography using micro- and nano-focused synchrotron beams.
Acta Crystallogr.,Sect.D, 71, 2015
1EU2
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BU of 1eu2 by Molmil
DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(TGCTCGCT)
分子名称: CYCLIC OLIGONUCLEOTIDE D(TGCTCGCT)
著者Escaja, N, Pedroso, E, Rico, M, Gonzalez, C.
登録日2000-04-13
公開日2001-01-24
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Dimeric Solution Structure of Two Cyclic Octamers: Four-Stranded DNA Structures Stabilized by A:T:A:T and G:C:G:C
J.Am.Chem.Soc., 122, 2000
4WLT
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BU of 4wlt by Molmil
High pressure protein crystallography of hen egg white lysozyme at 190 MPa
分子名称: CHLORIDE ION, Lysozyme C, SODIUM ION
著者Yamada, H, Nagae, T, Watanabe, N.
登録日2014-10-08
公開日2015-04-08
最終更新日2020-02-05
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献High-pressure protein crystallography of hen egg-white lysozyme
Acta Crystallogr.,Sect.D, 71, 2015
4WIN
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BU of 4win by Molmil
Crystal structure of the GATase domain from Plasmodium falciparum GMP synthetase
分子名称: GMP synthetase, NITRATE ION
著者Ballut, L, Violot, S, Haser, R, Aghajari, N.
登録日2014-09-26
公開日2015-12-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation.
Nat Commun, 6, 2015
1O9S
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BU of 1o9s by Molmil
Crystal structure of a ternary complex of the human histone methyltransferase SET7/9
分子名称: GENE FRAGMENT FOR HISTONE H3, HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC, ...
著者Xiao, B, Jing, C, Wilson, J.R, Walker, P.A, Vasisht, N, Kelly, G, Howell, S, Taylor, I.A, Blackburn, G.M, Gamblin, S.J.
登録日2002-12-18
公開日2003-02-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure and Catalytic Mechanism of the Human Histone Methyltransferase Set7/9
Nature, 421, 2003
4WM6
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BU of 4wm6 by Molmil
High pressure protein crystallography of hen egg white lysozyme at 950 MPa
分子名称: Lysozyme C, SODIUM ION
著者Yamada, H, Watanabe, N, Nagae, T.
登録日2014-10-08
公開日2015-04-08
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献High-pressure protein crystallography of hen egg-white lysozyme
Acta Crystallogr.,Sect.D, 71, 2015
4WG1
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BU of 4wg1 by Molmil
Room temperature crystal structure of lysozyme determined by serial synchrotron crystallography (micro focused beam - crystFEL)
分子名称: CHLORIDE ION, Lysozyme C
著者Coquelle, N, Brewster, A.S, Kapp, U, Shilova, A, Weimhausen, B, Sauter, N.K, Burghammer, M, Colletier, J.P.
登録日2014-09-17
公開日2015-05-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Raster-scanning serial protein crystallography using micro- and nano-focused synchrotron beams.
Acta Crystallogr.,Sect.D, 71, 2015
1EU6
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BU of 1eu6 by Molmil
DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CATTCATT)
分子名称: CYCLIC OLIGONUCLEOTIDE D(CATTCATT)
著者Escaja, N, Pedroso, E, Rico, M, Gonzalez, C.
登録日2000-04-14
公開日2001-01-24
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Dimeric Solution Structure of Two Cyclic Octamers: Four-Stranded DNA Structures Stabilized by A:T:A:T and G:C:G:C
J.Am.Chem.Soc., 122, 2000
6LIK
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BU of 6lik by Molmil
Crystal Structure of Lectin from Pleurotus ostreatus in complex with Galactose
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ...
著者Vajravijayan, S, Pletnev, S, Luo, Z, Iqbal, S, Nandhagopal, N, Gunasekaran, K.
登録日2019-12-11
公開日2020-08-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystallographic and calorimetric analysis on Pleurotus ostreatus lectin and its sugar complexes - promiscuous binding driven by geometry.
Int.J.Biol.Macromol., 152, 2020
1WH8
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BU of 1wh8 by Molmil
Solution structure of the third CUT domain of human Homeobox protein Cux-2
分子名称: Homeobox protein Cux-2
著者Nameki, N, Tochio, N, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2004-05-28
公開日2004-11-28
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the third CUT domain of human Homeobox protein Cux-2
To be Published
4WM2
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BU of 4wm2 by Molmil
High pressure protein crystallography of hen egg white lysozyme at 600 MPa
分子名称: CHLORIDE ION, Lysozyme C, SODIUM ION
著者Yamada, H, Nagae, T, Watanabe, N.
登録日2014-10-08
公開日2015-04-08
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献High-pressure protein crystallography of hen egg-white lysozyme
Acta Crystallogr.,Sect.D, 71, 2015
1NN0
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BU of 1nn0 by Molmil
Crystal structure of human thymidylate kinase with ddTMP and ADP
分子名称: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
登録日2003-01-12
公開日2003-03-18
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
4WSC
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BU of 4wsc by Molmil
Crystal structure of a GroELK105A mutant
分子名称: 60 kDa chaperonin
著者Lorimer, G.H, Ye, X, Fei, X, Yang, D, Corsepius, N, LaRonde, N.A.
登録日2014-10-26
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.04 Å)
主引用文献Crystal structure of a GroELK105A mutant
To Be Published

224004

件を2024-08-21に公開中

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